4,137 research outputs found
Assessment worlds colliding? Negotiating between discourses of assessment on an online open course
Using the badged open course, Taking your first steps into Higher Education, this case study examines how assessment on online open courses draws on concepts of assessment used within formal and informal learning. Our experience was that assessment used within open courses, such as massive open online courses, is primarily determined by the requirements of quality assurance processes to award a digital badge or statement of participation as well as what is technologically possible. However, this disregards much recent work in universities that use assessment in support of learning. We suggest that designers of online open courses should pay greater attention to the relationship of assessment and learning to improve participant course completion
Measurement of Antenna Surfaces from In- and Out-Of-Focus Beam Maps using Astronomical Sources
We present a technique for the accurate estimation of large-scale errors in
an antenna surface using astronomical sources and detectors. The technique
requires several out-of-focus images of a compact source and the
signal-to-noise ratio needs to be good but not unreasonably high. For a given
pattern of surface errors, the expected form of such images can be calculated
directly. We show that it is possible to solve the inverse problem of finding
the surface errors from the images in a stable manner using standard numerical
techniques. To do this we describe the surface error as a linear combination of
a suitable set of basis functions (we use Zernike polynomials). We present
simulations illustrating the technique and in particular we investigate the
effects of receiver noise and pointing errors. Measurements of the 15-m James
Clerk Maxwell telescope made using this technique are presented as an example.
The key result is that good measurements of errors on large spatial scales can
be obtained if the input images have a signal-to-noise ratio of order 100 or
more. The important advantage of this technique over transmitter-based
holography is that it allows measurements at arbitrary elevation angles, so
allowing one to characterise the large scale deformations in an antenna as a
function of elevation.Comment: 6 pages, 5 figures (accepted by Astronomy & Astrophysics
'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine
Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however, we know nothing of a role for Ketamine in modulating both structure and function of the human renal proximal tubule. In the current study we have used an established model cell line for human epithelial cells of the proximal tubule (HK2) to demonstrate that Ketamine evokes early changes in expression of proteins central to the adherens junction complex. Furthermore we use AFM single-cell force spectroscopy to assess if these changes functionally uncouple cells of the proximal tubule ahead of any overt loss in epithelial cell function. Our data suggests that Ketamine (24–48 hrs) produces gross changes in cell morphology and cytoskeletal architecture towards a fibrotic phenotype. These physical changes matched the concentration-dependent (0.1–1 mg/mL) cytotoxic effect of Ketamine and reflect a loss in expression of the key adherens junction proteins epithelial (E)- and neural (N)-cadherin and β-catenin. Down-regulation of protein expression does not involve the pro-fibrotic cytokine TGFβ, nor is it regulated by the usual increase in expression of Slug or Snail, the transcriptional regulators for E-cadherin. However, the loss in E-cadherin can be partially rescued pharmacologically by blocking p38 MAPK using SB203580. These data provide compelling evidence that Ketamine alters epithelial cell-to-cell adhesion and cell-coupling in the proximal kidney via a non-classical pro-fibrotic mechanism and the data provides the first indication that this illicit substance can have major implications on renal function. Understanding Ketamine-induced renal pathology may identify targets for future therapeutic intervention
ALMA Temporal Phase Stability and the Effectiveness of Water Vapor Radiometer
Atacama Large Millimeter/submillimeter Array (ALMA) will be the world largest
mm/submm interferometer, and currently the Early Science is ongoing, together
with the commissioning and science verification (CSV). Here we present a study
of the temporal phase stability of the entire ALMA system from antennas to the
correlator. We verified the temporal phase stability of ALMA using data, taken
during the last two years of CSV activities. The data consist of integrations
on strong point sources (i.e., bright quasars) at various frequency bands, and
at various baseline lengths (up to 600 m). From the observations of strong
quasars for a long time (from a few tens of minutes, up to an hour), we derived
the 2-point Allan Standard Deviation after the atmospheric phase correction
using the 183 GHz Water Vapor Radiometer (WVR) installed in each 12 m antenna,
and confirmed that the phase stability of all the baselines reached the ALMA
specification. Since we applied the WVR phase correction to all the data
mentioned above, we also studied the effectiveness of the WVR phase correction
at various frequencies, baseline lengths, and weather conditions. The phase
stability often improves a factor of 2 - 3 after the correction, and sometimes
a factor of 7 improvement can be obtained. However, the corrected data still
displays an increasing phase fluctuation as a function of baseline length,
suggesting that the dry component (e.g., N2 and O2) in the atmosphere also
contributes the phase fluctuation in the data, although the imperfection of the
WVR phase correction cannot be ruled out at this moment.Comment: Proc. SPIE 8444-125, in press (7 pages, 4 figures, 1 table
Out-Of-Focus Holography at the Green Bank Telescope
We describe phase-retrieval holography measurements of the 100-m diameter
Green Bank Telescope using astronomical sources and an astronomical receiver
operating at a wavelength of 7 mm. We use the technique with parameterization
of the aperture in terms of Zernike polynomials and employing a large defocus,
as described by Nikolic, Hills & Richer (2006). Individual measurements take
around 25 minutes and from the resulting beam maps (which have peak signal to
noise ratios of 200:1) we show that it is possible to produce low-resolution
maps of the wavefront errors with accuracy around a hundredth of a wavelength.
Using such measurements over a wide range of elevations, we have calculated a
model for the wavefront-errors due to the uncompensated gravitational
deformation of the telescope. This model produces a significant improvement at
low elevations, where these errors are expected to be the largest; after
applying the model, the aperture efficiency is largely independent of
elevation. We have also demonstrated that the technique can be used to measure
and largely correct for thermal deformations of the antenna, which often exceed
the uncompensated gravitational deformations during daytime observing.
We conclude that the aberrations induced by gravity and thermal effects are
large-scale and the technique used here is particularly suitable for measuring
such deformations in large millimetre wave radio telescopes.Comment: 10 pages, 7 figures (accepted by Astronomy & Astrophysics
Stellar Collisions and the Interior Structure of Blue Stragglers
Collisions of main sequence stars occur frequently in dense star clusters. In
open and globular clusters, these collisions produce merger remnants that may
be observed as blue stragglers. Detailed theoretical models of this process
require lengthy hydrodynamic computations in three dimensions. However, a less
computationally expensive approach, which we present here, is to approximate
the merger process (including shock heating, hydrodynamic mixing, mass
ejection, and angular momentum transfer) with simple algorithms based on
conservation laws and a basic qualitative understanding of the hydrodynamics.
These algorithms have been fine tuned through comparisons with the results of
our previous hydrodynamic simulations. We find that the thermodynamic and
chemical composition profiles of our simple models agree very well with those
from recent SPH (smoothed particle hydrodynamics) calculations of stellar
collisions, and the subsequent stellar evolution of our simple models also
matches closely that of the more accurate hydrodynamic models. Our algorithms
have been implemented in an easy to use software package, which we are making
publicly available (see http://vassun.vassar.edu/~lombardi/mmas/). This
software could be used in combination with realistic dynamical simulations of
star clusters that must take into account stellar collisions.Comment: This revised version has 37 pages, 13 figures, 4 tables; submitted to
ApJ; for associated software package, see
http://vassun.vassar.edu/~lombardi/mmas/ This revised version presents
additional comparisons with SPH results and slightly improved merger recipe
The surprising external upturn of the Blue Straggler radial distribution in M55
By combining high-resolution HST and wide-field ground based observations, in
ultraviolet and optical bands, we study the Blue Straggler Star (BSS)
population of the low density galactic globular cluster M55 (NGC 6809) over its
entire radial extent. The BSS projected radial distribution is found to be
bimodal, with a central peak, a broad minimum at intermediate radii, and an
upturn at large radii. Similar bimodal distributions have been found in other
globular clusters (M3, 47 Tucanae, NGC 6752, M5), but the external upturn in
M55 is the largest found to date. This might indicate a large fraction of
primordial binaries in the outer regions of M55, which seems somehow in
contrast with the relatively low (\sim 10%) binary fraction recently measured
in the core of this cluster.Comment: in press on Ap
Education and training for preventing and minimising workplace aggression directed toward healthcare workers (Protocol)
ROTSE All Sky Surveys for Variable Stars I: Test Fields
The ROTSE-I experiment has generated CCD photometry for the entire Northern
sky in two epochs nightly since March 1998. These sky patrol data are a
powerful resource for studies of astrophysical transients. As a demonstration
project, we present first results of a search for periodic variable stars
derived from ROTSE-I observations. Variable identification, period
determination, and type classification are conducted via automatic algorithms.
In a set of nine ROTSE-I sky patrol fields covering about 2000 square degrees
we identify 1781 periodic variable stars with mean magnitudes between m_v=10.0
and m_v=15.5. About 90% of these objects are newly identified as variable.
Examples of many familiar types are presented. All classifications for this
study have been manually confirmed. The selection criteria for this analysis
have been conservatively defined, and are known to be biased against some
variable classes. This preliminary study includes only 5.6% of the total
ROTSE-I sky coverage, suggesting that the full ROTSE-I variable catalog will
include more than 32,000 periodic variable stars.Comment: Accepted for publication in AJ 4/00. LaTeX manuscript. (28 pages, 11
postscript figures and 1 gif
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