Rapidly Progressive Dementia Due to Mycobacterium neoaurum Meningoencephalitis

Dementia developed in a patient with widespread neurologic manifestations; she died within 5 months. Pathologic findings showed granulomatous inflammation with caseation necrosis, foreign body–type giant cells, and proliferative endarteritis with vascular occlusions. Broad-range polymerase chain reaction identified Mycobacterium neoaurum as the possible pathogen. Central nervous system infection by M. neoaurum may result in rapidly progressive dementia

Stress biology:Complexity and multifariousness in health and disease

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.</p

Indigenous Inclusion in Public Policy: A Comparison of Urban Aboriginal Peoples in Canada and Travellers in Ireland

To what extent are voluntary organizations included in the policy processes that make decisions regarding the needs and interests of Indigenous groups? As politically underrepresented groups, both urban Aboriginal Peoples and Travellers rely on voluntary organizations to provide culturally appropriate programs and services and to advocate on their behalf. Applying a scalar analysis, this project isolated three key concepts that are critical to their inclusion in policy processes. First, is the incorporation of their issues and interests in cultural programs and services. Second, is group representation in policy processes. And third is their collaboration with government. On balance, it appears that urban Aboriginal Peoples in Canada have moved closer to inclusion in policy processes than Travellers