5 research outputs found

    Finishing the euchromatic sequence of the human genome

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    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

    Neurotoxina tetánica: características e importancia

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    ResumenEl Clostridium tetani es una bacteria Gram positiva, estrictamente anaerobia y no invasiva. Este microorganismo produce la enfermedad llamada tétanos, la cual se presenta cuando la toxina tetánica, producida por la bacteria en laceraciones provocadas en piel o mucosas, viaja por vía hematógena o linfática hasta el Sistema Nervioso. La neurotoxina actpua en las interneuronas GABAérgicas y glicinérgicas ubicadas a nivel medular en donde se une a una proteína de las vesículas sinápticas, la sinaptobrevina II(VAMP II), inhibiendo su funsión con la membrana de la neurona presináptica y evitando de esta manera la liberación del neurotransmisor.Palabras clave: Tétanos, toxina tetánica, Clostridium tetani, sinapsis, interneuronas

    Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.

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