Mortality following a brain tumour diagnosis in patients with multiple sclerosis

Objectives: As brain tumours and their treatment may theoretically have a poorer prognosis in inflammatory central nervous system diseases such as multiple sclerosis (MS), all-cause mortality following a brain tumour diagnosis was compared between patients with and without MS. The potential role of age at tumour diagnosis was also examined. Setting: Hospital inpatients in Sweden with assessment of mortality in hospital or following discharge. Participants: Swedish national registers identified 20 543 patients with an MS diagnosis (1969-2005) and they were matched individually to produce a comparison cohort of 204 163 members of the general population without MS. Everyone with a primary brain tumour diagnosis was selected for this study: 111 with MS and 907 without MS. Primary and secondary outcome measures: 5-year mortality risk following brain tumour diagnosis and age at brain tumour diagnosis. Results: A non-statistically significant lower mortality risk among patients with MS (lower for those with tumours of high-grade and uncertain-grade malignancy and no notable difference for low-grade tumours) produced an unadjusted HR (and 95% CI) of 0.75 (0.56 to 1.02). After adjustment for age at diagnosis, grade of malignancy, sex, region of residence and socioeconomic index, the HR is 0.91 (0.67-1.24). The change in estimate was largely due to adjustment for age at brain tumour diagnosis, as patients with MS were on average 4.7 years younger at brain tumour diagnosis than those in the comparison cohort (p<0.001). Conclusions: Younger age at tumour diagnosis may contribute to mortality reduction in those with highgrade and uncertain-grade brain tumours. Survival following a brain tumour is not worse in patients with MS; even after age at brain tumour diagnosis and grade of malignancy are taken into account

ECONOMIC GROWTH AND INCOME INEQUALITY IN SUB-SAHARAN AFRICA

Economies of Sub-Saharan African (SSA) countries have been growing slowly in recent time. Economic growth is thought to affect inequality but not much is known about the nature of such relationship in SSA and there is no concordance among the few available. This paper examined the relationship between economic growth and inequality in the region using data from 1990 to 2017estimated with the Panel Autoregressive Distributed Lag (ARDL) Model and Granger Causality. Hausman’s test suggested the superiority of the Pooled Mean Group (PMG) over the Mean Group (MG) Model. The PMG results showed that economic growth had significant and negative effect on income inequality (proxy by GINI-coefficient) in the long run suggesting a state of the later part of the Kuznet curve. This is in addition to the negative effect in the short run which is contrary to the theory. Furthermore, the result of the Granger Causality test revealed evidence of unidirectional relationship running from economic growth to income inequality in the region. Therefore, the study recommended that governments of Sub-Saharan African countries should implement policies and programmes capable of sustaining and improving inclusive growth in order to avoid high income inequality in the region. &nbsp; &nbsp; &nbsp

Layer by Layer Silver Acetate based Coating on Glass and Cement Substrates to Tailor Reflectance and Conductance

Tailoring reflectance and conductance was achieved through layer by layer assembly of a silver acetate based multilayer coating. The coating was applied over glass and cement substrates by sol-gel spin coating and by brush painting, respectively. The structural, optical and electrical characteristics and the composition of the coating were studied. The diffraction peaks for all films revealed that the face-centered cubic lattice of the silver crystal structure and the films with more layers had a higher degree of crystallinity. The optical characteristics showed that having more layers leads to decreasing transmittance and increasing reflectance. The I-V characteristics of all samples showed typical ohmic contacts in a voltage range of -1 to 1 V. The conductance increased drastically as the coating developed into multiple layers. The eight-layer coated glass and cement based substrates had very low surface resistance, at 4 Ω and 2 Ω at 1 V, respectively. The study also revealed that the resistance behavior of a multilayered film generally is thermally stable for annealing up to 400 °C. The coating resistance was significantly increased by further increasing the post-annealing beyond 500 °C. The studied multilayered coating can be used to tailor the reflectance and conductance of dielectric substrate surfaces for various optoelectronics and sensor device applications

INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLOXACIN GRANULES AND TABLETS

Objective: To investigate the possible individual and joined influences that binding solution concentration, drying temperature and drying duration might have on the physiochemical attributes of granules and tablets using norfloxacin as a model drug. Methods: According to implemented 23 central composite designs, each of the investigated variables were examined at 5 different levels through different 16 formulation runs. For each formulation, obtained granules were qualified for their bulk density, tap density, Hausner ratio, percent of fine and drug content properties whereas the respective tablets were evaluated for their weight variation, drug content, friability, hardness, disintegration, and drug dissolution attributes. Results: Indicated that concentration of binder solution, as compared to drying temperature and drying duration, measured more profound influences on granules' tap density, Hausner ratio, % fine and drug content either through its individual linear and quadratic effects or through its joint effect with drying durations (p&lt;0.05 at 95% CI for all influences). Whilst tablets' friability appeared to be noticeably influenced by the three investigated variables (P ranged 0.001-0.017 at 95% CI), tablets' hardness and disintegration were found to be considerably affected only by binder solution concentration (p = 0.001 and 0.082 at 95% CI, respectively). Moreover, none of the investigated variables has measured a significant influence on tablets' drug content or drug dissolution properties. Conclusion: The study concluded that quadratic and joint influences of variables on attributes of granule and tablet formulations shouldn't be overlooked and better to be considered in the screening design

Thermal quantum and classical correlations in two qubit XX model in a nonuniform external magnetic field

We investigate how thermal quantum discord (QD) and classical correlations (CC) of a two-qubit one-dimensional XX Heisenberg chain in thermal equilibrium depend on the temperature of the bath as well as on nonuniform external magnetic fields applied to two qubits and varied separately. We show that the behavior of QD differs in many unexpected ways from the thermal entanglement (EOF). For the nonuniform case (B1 = -B2), we find that QD and CC are equal for all values of (B1 = -B2) and for different temperatures. We show that, in this case, the thermal states of the system belong to a class of mixed states and satisfy certain conditions under which QD and CC are equal. The specification of this class and the corresponding conditions are completely general and apply to any quantum system in a state in this class satisfying these conditions. We further find that the relative contributions of QD and CC can be controlled easily by changing the relative magnitudes of B1 and B2. Finally, we connect our results with the monogamy relations between the EOF, CC and the QD of two qubits and the environment.Comment: 8 pages, 13 figures. We connect our results with the monogamy relations between the EOF, CC and the QD of two qubits and the environmen

Oscillation behavior of second order nonlinear neutral differential equations with deviating arguments

Oscillation criteria are established for second order nonlinear neutral differential equations with deviating arguments of the form $$r(t)\psi(x(t))|z'(t)|^{\alpha -1} z'(t)+ \int_a^b q(t,\xi)f(x(g(t,\phi)))d\sigma (\xi) =0,\quad t\gt t_0,$$ where $\alpha \gt 0$ and $z(t)= x(t)+p(t)x(t-\tau)$. Our results improve and extend some known results in the literature. Some illustrating examples are also provided to show the importance of our results

A suspected case of digitalis toxicity secondary to therapeutic management of congestive heart failure in a Boerboel dog

A 15 months old male Boerboel, weighing 25kg presented to Veterinary Teaching Hospital, Abeokuta, Nigeria, with complaint of abdominal distention, emaciation and anorexia was diagnosed of congestive heart failure (CHF) of unknown etiology. At presentation, prominent S- wave voltages in lead II, III electrocardiogram, a positive R-wave in lead AVR and a mean electrical axis of -900 suggestive of right ventricular enlargement were evident. A right atrial enlargement was also suspected due to the presence of a tented P-wave on the electrocardiogram. Digoxin was administered at 0.01 mg/kg orally, once daily to increase cardiac contractility and reduce heart rate; Enalapril given at 0.5 mg/kg orally once daily was to blunt the renin angiotensin aldosterone response, Furosemide at 2mg/kg orally, once daily was administered to increase natriuresis and diuresis. After 2 weeks of medication the dogs exhibited signs of digitalis toxicity such as ventricular premature contraction, ventricular tachycardia. This case is a rare occurrence and has not been reported in our veterinary clinics. The management of CHF with standard dose regime of digitalis requires therapeutic drug monitoring as it could result in breed specific toxicity

Hadron Production in Neutrino-Nucleon Interactions at High Energies

The multi-particle production at high energy neutrino- nucleon collisions are investigated through the analysis of the data of the experiment CERN-WA-025 at neutrino energy less than 260GeV and the experiments FNAL-616 and FNAL-701 at energy range 120-250 GeV. The general features of these experiments are used as base to build a hypothetical model that views the reaction by a Feynman diagram of two vertices. The first of which concerns the weak interaction between the neutrino and the quark constituents of the nucleon. At the second vertex, a strong color field is assumed to play the role of particle production, which depend on the momentum transferred from the first vertex. The wave function of the nucleon quarks are determined using the variation method and relevant boundary conditions are applied to calculate the deep inelastic cross sections of the virtual diagram.Comment: 6 pages PDF forma

Characteristics of a cohort of high-risk men who have sex with men on pre-exposure prophylaxis reporting transgender sexual partners.

Transgender people continue to be at high-risk for HIV acquisition, but little is known about the characteristics of their sexual partners. To address this gap, we examined sociodemographic and sexual characteristics of cisgender men who have sex with men (MSM) on pre-exposure prophylaxis (PrEP) reporting transgender sexual partners.A cohort of 392 MSM in southern California in a randomized clinical trial for PrEP adherence were followed from 2013 to 2016. Multivariable generalized estimating equation and logistic models identified characteristics of MSM reporting transgender sexual partners and PrEP adherence.Only 14 (4%) MSM reported having transgender sexual partners. MSM were more likely to report transgender partners if they were African American, had incident chlamydia, reported injection drug-using sexual partners, or received items for sex. Most associations remained significant in the multivariable model: African American (adjusted odds ratio [AOR] 11.20, P = .01), incident chlamydia (AOR 3.71, P = .04), and receiving items for sex (AOR 5.29, P = .04). There were no significant differences in PrEP adherence between MSM reporting transgender partners and their counterpart.MSM who report transgender sexual partners share characteristics associated with individuals with high HIV prevalence. Identifying this group distinct from larger cohorts of MSM could offer new HIV prevention opportunities for this group of MSM and the transgender community