Strengthening Access to Communications Policy & Regulatory Guidelines for Satellite Services

This work is designed to help bridge the Regulatory Divide that continues to thwart end users\u27 efforts to obtain affordable communications. From tele-medicine to distance learning to rural telecenters to disaster recovery to enterprise networks, the satellite industry is offering not only telecommunications solutions for the have nots , but also the regulatory tools to enable the public sector to fulfill their policy objectives

Overview: The View From 22,300 Miles High

Asia\u27s geography, claiming many of the world\u27s highest peaks, has provided a dramatic setting for a climbing expedition that began decades ago, when the satellite communications community took its first step on the lower slopes of the mountain

Future Solutions: Universal Access

Today, the nations of the world have an immediate opportunity to advance essential telecommunication policy objectives through harmonisation of regulations governing the use of fixed satellite-based network solutions

Future Solutions: Access to ICT: A Tale of Three Briefings

If your inbox is anything like mine, then you already know that the publication of satellite communications reports has become an industry unto itself. But that\u27s not to say that it\u27s always an end unto itself. On the contrary

Regulatory Reform: Asia\u27s Great Step Forward

This paper was presented at Connect-World Asia Pacific, June 2002. Forget about a great leap forward. All that\u27s needed to facilitate communications in Asia are a few small steps. Indeed, today all nations of the world have an immediate opportunity to advance essential telecommunication policy objectives through harmonisation of regulations governing the use of telecommunications solutions

Issue 7: From the Guest Editors

During the past 15 years, the international satellite communications industry has been developing and refining network solutions such that today, there are more than one million so-called Very Small Aperture Terminal (VSAT) systems installed and operating in more than 120 countries

Issue 7: Contributors

List of Issue 7 Contributors

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

Accumulation of β-Amyloid (βA) is a key pathogenetic factor in Alzheimer's disease; however, the normal function of βA is unknown. Recent studies have shown that βA can inhibit growth of bacteria and fungi. In this paper we show that βA also inhibits replication of seasonal and pandemic strains of H3N2 and H1N1 influenza A virus (IAV) in vitro. The 42 amino acid fragment of βA (βA42) had greater activity than the 40 amino acid fragment. Direct incubation of the virus with βA42 was needed to achieve optimal inhibition. Using quantitative PCR assays βA42 was shown to reduce viral uptake by epithelial cells after 45 minutes and to reduce supernatant virus at 24 hours post infection. βA42 caused aggregation of IAV particles as detected by light transmission assays and electron and confocal microscopy. βA42 did not stimulate neutrophil H2O2 production or extracellular trap formation on its own, but it increased both responses stimulated by IAV. In addition, βA42 increased uptake of IAV by neutrophils. βA42 reduced viral protein synthesis in monocytes and reduced IAV-induced interleukin-6 production by these cells. Hence, we demonstrate for the first time that βA has antiviral activity and modulates viral interactions with phagocytes

Barn-Raising on the Digital Frontier: The L.A.U.N.C.H. Collaborative

A meta-analysis of oncology papers from around the world revealed that cancer patients who lived more than 50 miles away from hospital centers routinely presented with more advanced stages of disease at diagnosis, exhibited lower adherence to prescribed treatments, presented with poorer diagnoses, and reported a lower quality of life than patients who lived nearer to care facilities. Connected health approaches—or the use of broadband and telecommunications technologies to evaluate, diagnose, and monitor patients beyond the clinic—are becoming an indispensable tool in medicine to overcome the obstacle of distance

BSP‐SLIM: A blind low‐resolution ligand‐protein docking approach using predicted protein structures

We developed BSP‐SLIM, a new method for ligand–protein blind docking using low‐resolution protein structures. For a given sequence, protein structures are first predicted by I‐TASSER; putative ligand binding sites are transferred from holo‐template structures which are analogous to the I‐TASSER models; ligand–protein docking conformations are then constructed by shape and chemical match of ligand with the negative image of binding pockets. BSP‐SLIM was tested on 71 ligand–protein complexes from the Astex diverse set where the protein structures were predicted by I‐TASSER with an average RMSD 2.92 Å on the binding residues. Using I‐TASSER models, the median ligand RMSD of BSP‐SLIM docking is 3.99 Å which is 5.94 Å lower than that by AutoDock; the median binding‐site error by BSP‐SLIM is 1.77 Å which is 6.23 Å lower than that by AutoDock and 3.43 Å lower than that by LIGSITE CSC . Compared to the models using crystal protein structures, the median ligand RMSD by BSP‐SLIM using I‐TASSER models increases by 0.87 Å, while that by AutoDock increases by 8.41 Å; the median binding‐site error by BSP‐SLIM increase by 0.69Å while that by AutoDock and LIGSITE CSC increases by 7.31 Å and 1.41 Å, respectively. As case studies, BSP‐SLIM was used in virtual screening for six target proteins, which prioritized actives of 25% and 50% in the top 9.2% and 17% of the library on average, respectively. These results demonstrate the usefulness of the template‐based coarse‐grained algorithms in the low‐resolution ligand–protein docking and drug‐screening. An on‐line BSP‐SLIM server is freely available at http://zhanglab.ccmb.med.umich.edu/BSP‐SLIM . Proteins 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89455/1/23165_ftp.pd