490 research outputs found
Jubiläum in Kiel: Das 10. Kieler Insolvenz-Symposium
In Kiel fand am 23.5. und 24. 5. 2014 das mittlerweile 10.
Kieler Insolvenz-Symposium statt. Zur Jubiläumsveranstal-
tung erschienen weit ĂĽber 170 Teilnehmer, um sich der Dis-
kussion und dem Austausch zu aktuellen Problemen und
Themen des Insolvenzrechts zu stellen. Die Veranstaltung
zeichnet sich durch seine ĂĽberregionale Bedeutung aus
und stellt die wohl größte juristische Veranstaltung seiner
Art in Schleswig-Holstein dar. Neben der groĂźen fachlichen
Bedeutung ist das Kernziel der Veranstaltung, Doktoran-
den und Studierende mit den Praktikern aus der Fachwelt
des Insolvenzrechts zusammenzufĂĽhren, um sich fach-
lich auszutauschen. In diesem Jahr lagen dieSchwerpunkte
der Veranstaltung ĂĽberwiegend in den Entwicklungen
des VergĂĽtungsrechts und den anstehenden Reformvor-
haben
Iron cycling and stable Fe isotope fractionation in Antarctic shelf sediments, King George Island
Iron (Fe) fluxes from reducing sediments and subglacial environments are potential sources
of bioavailable Fe into the Southern Ocean. Stable Fe isotopes (δ56Fe ) are considered a proxy for
Fe sources and reaction pathways, but respective data are scarce and Fe cycling in complex natural
environments is not understood sufficiently to constrain respective δ56Fe “endmembers” for
different types of sediments, environmental conditions, and biogeochemical processes.
We present δ56Fe data from pore waters and sequentially extracted sedimentary Fe phases
of two contrasting sites in Potter Cove (King George Island, Antarctic Peninsula), a bay that is
affected by fast glacier retreat. Sediments close to the glacier front contain more easily reducible Fe oxides and pyrite and show a broader ferruginous zone, compared to sediments close to the icefree
coast, where surficial oxic meltwater streams discharge into the bay. Pyrite in sediments close
to the glacier front predominantly derives from eroded bedrock. For the high amount of easily
reducible Fe oxides proximal to the glacier we suggest mainly subglacial sources, where Fe
liberation from comminuted material beneath the glacier is coupled to biogeochemical weathering
processes (likely pyrite oxidation or dissimilatory iron reduction, DIR). Our strongest argument for
a subglacial source of the highly reactive Fe pool in sediments close to the glacier front is its
predominantly negative δ56Fe signature that remains constant over the whole ferruginous zone.
This implies in situ DIR does not significantly alter the stable Fe isotope composition of the
accumulated Fe oxides. The nonetheless overall light δ56Fe signature of easily reducible Fe oxides
suggests pre-depositional microbial cycling as it occurs in potentially anoxic subglacial
environments. The strongest 56Fe-depletion in pore water and most reactive Fe oxides was
observed in sediments influenced by oxic meltwater discharge. The respective site showed a
condensed redox zonation and a pore water δ56Fe profile typical for in-situ Fe cycling.
We demonstrate that the potential of pore water δ56Fe as a proxy for benthic Fe fluxes is
not straight-forward due to its large variability in marine shelf sediments at small spatial scales (-
2.4‰ at the site proximal to oxic meltwater discharge vs. -0.9‰ at the site proximal to the marine
glacier terminus, both at 2 cm sediment depth). The controlling factors are multifold and include
the amount and reactivity of reducible Fe oxides and organic matter, the isotopic composition of
the primary and secondary ferric substrates, sedimentation rates, and physical reworking
(bioturbation, ice scraping). The application of δ56Fe geochemistry may prove valuable in
investigating biogeochemical weathering and Fe cycling in subglacial environments. This requires,
however (similarly to the use of δ56Fe for the quantification of benthic fluxes), that the spatial and
temporal variability of the isotopic endmember is known and accounted for. Since geochemical data
from subglacial environments are very limited, further studies are needed in order to sufficiently assess Fe cycling and fractionation at glacier beds and the composition of discharges from those
areas
Cluster Forschungsdaten – Kooperative Forschungsservices in Österreich
Der Cluster Forschungsdaten spielt eine entscheidende Rolle bei der Koordinierung des Zusammenspiels von Forschungsinformationssystemen, Forschungsdatenmanagement und digitalen Technologien/Infrastrukturen. Ein besonderer Fokus liegt dabei auf der Identifizierung von Synergien und Potenzialen für eine ressourcenoptimierte Zusammenarbeit zwischen den verschiedenen Forschungseinrichtungen des Landes. Darüber hinaus strebt der Cluster Forschungsdaten eine einheitliche Präsenz bei der Entwicklung und Zusammenführung von forschungsunterstützenden Services auf allen Ebenen des Forschungsdaten- und Forschungsinformations-Managements an. Dies gewährleistet eine effiziente und kohärente Gestaltung der Prozesse
Zukunftsweisender Forschungssupport: Das Digitalisierungsprojekt RIS Synergy
Das Projekt RIS Synergy (2020–2024) verfolgt institutionsübergreifend wesentliche Aspekte digitaler Transformation: Im Teilprojekt Schnittstellen und Standards werden standardisierte Austauschmöglichkeiten für Systeme von Förderorganisationen, Forschungsstätten und der öffentlichen Verwaltung geschaffen. Das Teilprojekt Konzeptstudie Forschungsportal befasst sich mit Rahmenbedingungen und Anforderungen eines nationalen Forschungsportals. RIS Synergy schafft Entlastung und Sichtbarkeit für den Wissenschaftsbetrieb durch die Umsetzung von Standards, die Digitalisierung von Services sowie die Vernetzung von Expertise. Der vorliegende Artikel gibt Einblick in Herangehensweise und Best Practices aus dem Projekt
Quantum tunneling and stochastic resonance
Stochastic resonance (SR) occurs in nonlinear dynamical systems when the response to a weak coherent input is enhanced by the presence of noise. While classical SR presently is an intensely studied phenomenon, the role of quantum fluctuations has only started to be explored. We study SR in the temperature range where quantum tunneling corrections to the classical rate of activation are relevant. For a particle subject to moderate-to-large friction, we show that the semiclassical SR can be enhanced considerably by quantum fluctuations, as compared to the predictions of a classical analysis
Quantum tunneling and stochastic resonance
Stochastic resonance (SR) occurs in nonlinear dynamical systems when the response to a weak coherent input is enhanced by the presence of noise. While classical SR presently is an intensely studied phenomenon, the role of quantum fluctuations has only started to be explored. We study SR in the temperature range where quantum tunneling corrections to the classical rate of activation are relevant. For a particle subject to moderate-to-large friction, we show that the semiclassical SR can be enhanced considerably by quantum fluctuations, as compared to the predictions of a classical analysis
Quantum tunneling and stochastic resonance
Stochastic resonance (SR) occurs in nonlinear dynamical systems when the response to a weak coherent input is enhanced by the presence of noise. While classical SR presently is an intensely studied phenomenon, the role of quantum fluctuations has only started to be explored. We study SR in the temperature range where quantum tunneling corrections to the classical rate of activation are relevant. For a particle subject to moderate-to-large friction, we show that the semiclassical SR can be enhanced considerably by quantum fluctuations, as compared to the predictions of a classical analysis
A Case of Linear Porokeratosis Superimposed on Disseminated Superficial Actinic Porokeratosis
We present a female patient with linear porokeratosis of her right arm since childhood. At the age of 67 years she additionally developed disseminated superficial actinic porokeratosis (DSAP) involving both lower legs. This uncommon coexistence of two different types of porokeratosis fulfils the clinical criteria of a type 2 segmental manifestation of an autosomal dominant skin disorder, being superimposed on the ordinary nonsegmental lesions and reflecting loss of heterozygosity that occurred at an early developmental stage. In DSAP molecular evidence of this concept is so far lacking, but such proof has already been provided in several other autosomal dominant skin disorders. Molecular analysis of cases of type 2 segmental involvement may help elucidate the genetic defect causing DSAP
Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids
The mucin MUC1 is a glycoprotein involved in fundamental biological processes, which can be found over-expressed and with a distinctly altered glycan pattern on epithelial tumor cells; thus it is a promising target structure in the quest for effective carbohydrate-based cancer vaccines and immunotherapeutics. Natural glycopeptide antigens indicate only a low immunogenicity and a T-cell independent immune response; however, this major drawback can be overcome by coupling of glycopeptide antigens multivalently to immunostimulating carrier platforms. In particular, gold nanoparticles are well suited as templates for the multivalent presentation of glycopeptide antigens, due to their remarkably high surface-to-volume ratio in combination with their high biostability. In this work the synthesis of novel MUC1-glycopeptide antigens and their coupling to gold nanoparticles of different sizes are presented. In addition, the development of a new dot-blot immunoassay to test the potential antigen-antibody binding is introduced
Identification of mineralocorticoid receptor target genes in the mouse hippocampus
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