61 research outputs found
Non-adiabatic holonomic quantum computation in linear system-bath coupling
Non-adiabatic holonomic quantum computation in decoherence-free subspaces
protects quantum information from control imprecisions and decoherence. For the
non-collective decoherence that each qubit has its own bath, we show the
implementations of two non-commutable holonomic single-qubit gates and one
holonomic nontrivial two-qubit gate that compose a universal set of
non-adiabatic holonomic quantum gates in decoherence-free-subspaces of the
decoupling group, with an encoding rate of . The proposed scheme
is robust against control imprecisions and the non-collective decoherence, and
its non-adiabatic property ensures less operation time. We demonstrate that our
proposed scheme can be realized by utilizing only two-qubit interactions rather
than many-qubit interactions. Our results reduce the complexity of practical
implementation of holonomic quantum computation in experiments. We also discuss
the physical implementation of our scheme in coupled microcavities.Comment: 2 figures; accepted by Sci. Re
Self-Convinced Prompting: Few-Shot Question Answering with Repeated Introspection
While large language models (LLMs) such as ChatGPT and PaLM have demonstrated
remarkable performance in various language understanding and generation tasks,
their capabilities in complex reasoning and intricate knowledge utilization
still fall short of human-level proficiency. Recent studies have established
the effectiveness of prompts in steering LLMs towards generating desired
outputs. Building on these insights, we introduce a novel framework that
harnesses the potential of large-scale pre-trained language models, to
iteratively enhance performance of the LLMs. Our framework incorporates three
components: \textit{Normal CoT}, a \textit{Convincer}, and an
\textit{Answerer}. It processes the output of a typical few-shot
chain-of-thought prompt, assesses the correctness of the response, scrutinizes
the answer, refines the reasoning, and ultimately produces a new solution.
Experimental results on the 7 datasets of miscellaneous problems validate the
efficacy of the Self-Convince framework, achieving substantial improvements
compared to the baselines. This study contributes to the burgeoning body of
research focused on integrating pre-trained language models with tailored
prompts and iterative refinement processes to augment their performance in
complex tasks
DETRs with Hybrid Matching
One-to-one set matching is a key design for DETR to establish its end-to-end
capability, so that object detection does not require a hand-crafted NMS
(non-maximum suppression) to remove duplicate detections. This end-to-end
signature is important for the versatility of DETR, and it has been generalized
to broader vision tasks. However, we note that there are few queries assigned
as positive samples and the one-to-one set matching significantly reduces the
training efficacy of positive samples. We propose a simple yet effective method
based on a hybrid matching scheme that combines the original one-to-one
matching branch with an auxiliary one-to-many matching branch during training.
Our hybrid strategy has been shown to significantly improve accuracy. In
inference, only the original one-to-one match branch is used, thus maintaining
the end-to-end merit and the same inference efficiency of DETR. The method is
named H-DETR, and it shows that a wide range of representative DETR methods can
be consistently improved across a wide range of visual tasks, including
DeformableDETR, PETRv2, PETR, and TransTrack, among others. The code is
available at: https://github.com/HDETRComment: CVPR 2023. The code is available at: https://github.com/HDET
A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources
KEY POINTS: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) capture patient-specific genotype-phenotype relationships, as well as cell-to-cell variability of cardiac electrical activity Computational modelling and simulation provide a high throughput approach to reconcile multiple datasets describing physiological variability, and also identify vulnerable parameter regimes We have developed a whole-cell model of iPSC-CMs, composed of single exponential voltage-dependent gating variable rate constants, parameterized to fit experimental iPSC-CM outputs We have utilized experimental data across multiple laboratories to model experimental variability and investigate subcellular phenotypic mechanisms in iPSC-CMs This framework links molecular mechanisms to cellular-level outputs by revealing unique subsets of model parameters linked to known iPSC-CM phenotypes ABSTRACT: There is a profound need to develop a strategy for predicting patient-to-patient vulnerability in the emergence of cardiac arrhythmia. A promising in vitro method to address patient-specific proclivity to cardiac disease utilizes induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). A major strength of this approach is that iPSC-CMs contain donor genetic information and therefore capture patient-specific genotype-phenotype relationships. A cited detriment of iPSC-CMs is the cell-to-cell variability observed in electrical activity. We postulated, however, that cell-to-cell variability may constitute a strength when appropriately utilized in a computational framework to build cell populations that can be employed to identify phenotypic mechanisms and pinpoint key sensitive parameters. Thus, we have exploited variation in experimental data across multiple laboratories to develop a computational framework for investigating subcellular phenotypic mechanisms. We have developed a whole-cell model of iPSC-CMs composed of simple model components comprising ion channel models with single exponential voltage-dependent gating variable rate constants, parameterized to fit experimental iPSC-CM data for all major ionic currents. By optimizing ionic current model parameters to multiple experimental datasets, we incorporate experimentally-observed variability in the ionic currents. The resulting population of cellular models predicts robust inter-subject variability in iPSC-CMs. This approach links molecular mechanisms to known cellular-level iPSC-CM phenotypes, as shown by comparing immature and mature subpopulations of models to analyse the contributing factors underlying each phenotype. In the future, the presented models can be readily expanded to include genetic mutations and pharmacological interventions for studying the mechanisms of rare events, such as arrhythmia triggers.S
MW-GAN: Multi-warping GAN for caricature generation with multi-style geometric exaggeration
Given an input face photo, the goal of caricature generation is to produce stylized, exaggerated caricatures that share the same identity as the photo. It requires simultaneous style transfer and shape exaggeration with rich diversity, and meanwhile preserving the identity of the input. To address this challenging problem, we propose a novel framework called Multi-Warping GAN (MW-GAN), including a style network and a geometric network that are designed to conduct style transfer and geometric exaggeration respectively. We bridge the gap between the style/landmark space and their corresponding latent code spaces by a dual way design, so as to generate caricatures with arbitrary styles and geometric exaggeration, which can be specified either through random sampling of latent code or from a given caricature sample. Besides, we apply identity preserving loss to both image space and landmark space, leading to a great improvement in quality of generated caricatures. Experiments show that caricatures generated by MW-GAN have better quality than existing methods
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