Improving Model Drift for Robust Object Tracking

Discriminative correlation filters show excellent performance in object tracking. However, in complex scenes, the apparent characteristics of the tracked target are variable, which makes it easy to pollute the model and cause the model drift. In this paper, considering that the secondary peak has a greater impact on the model update, we propose a method for detecting the primary and secondary peaks of the response map. Secondly, a novel confidence function which uses the adaptive update discriminant mechanism is proposed, which yield good robustness. Thirdly, we propose a robust tracker with correlation filters, which uses hand-crafted features and can improve model drift in complex scenes. Finally, in order to cope with the current trackers' multi-feature response merge, we propose a simple exponential adaptive merge approach. Extensive experiments are performed on OTB2013, OTB100 and TC128 datasets. Our approach performs superiorly against several state-of-the-art trackers while runs at speed in real time.Comment: 7 pages, 6 figures, 4 table

Efficient refinements on YOLOv3 for real-time detection and assessment of diabetic foot Wagner grades

Currently, the screening of Wagner grades of diabetic feet (DF) still relies on professional podiatrists. However, in less-developed countries, podiatrists are scarce, which led to the majority of undiagnosed patients. In this study, we proposed the real-time detection and location method for Wagner grades of DF based on refinements on YOLOv3. We collected 2,688 data samples and implemented several methods, such as a visual coherent image mixup, label smoothing, and training scheduler revamping, based on the ablation study. The experimental results suggested that the refinements on YOLOv3 achieved an accuracy of 91.95% and the inference speed of a single picture reaches 31ms with the NVIDIA Tesla V100. To test the performance of the model on a smartphone, we deployed the refinements on YOLOv3 models on an Android 9 system smartphone. This work has the potential to lead to a paradigm shift for clinical treatment of the DF in the future, to provide an effective healthcare solution for DF tissue analysis and healing status.Comment: 11 pages with 11 figure

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism

The Hippo pathway plays essential roles in organ size control and cancer prevention via restricting its downstream effector, Yes-associated protein (YAP). Previous studies have revealed an oncogenic function of YAP in reprogramming glucose metabolism, while the underlying mechanism remains to be fully clarified. Accumulating evidence suggests long noncoding RNAs (lncRNAs) as attractive therapeutic targets, given their roles in modulating various cancer-related signaling pathways. In this study, we report that lncRNA breast cancer anti-estrogen resistance 4 (BCAR4) is required for YAP-dependent glycolysis. Mechanistically, YAP promotes the expression of BCAR4, which subsequently coordinates the Hedgehog signaling to enhance the transcription of glycolysis activators HK2 and PFKFB3. Therapeutic delivery of locked nucleic acids (LNAs) targeting BCAR4 attenuated YAP-dependent glycolysis and tumor growth. The expression levels of BCAR4 and YAP are positively correlated in tissue samples from breast cancer patients, where high expression of both BCAR4 and YAP is associated with poor patient survival outcome. Taken together, our study not only reveals the mechanism by which YAP reprograms glucose metabolism, but also highlights the therapeutic potential of targeting YAP-BCAR4-glycolysis axis for breast cancer treatment