Step by step: Stepping strategies to prevent falling while walking

Dieen, J.H. van [Promotor]Beek, P.J. [Promotor]Houdijk, J.H.P. [Copromotor

Comparing and calibrating black hole mass estimators for distant active galactic nuclei

Black hole mass is a fundamental property of active galactic nuclei (AGNs). In the distant universe, black hole mass is commonly estimated using the MgII, Hbeta, or Halpha emission line widths and the optical/UV continuum or line luminosities, as proxies for the characteristic velocity and size of the broad-line region. Although they all have a common calibration in the local universe, a number of different recipes are currently used in the literature. It is important to verify the relative accuracy and consistency of the recipes, as systematic changes could mimic evolutionary trends when comparing various samples. At z=0.36, all three lines can be observed at optical wavelengths, providing a unique opportunity to compare different empirical recipes. We use spectra from the Keck Telescope and the Sloan Digital Sky Survey to compare black hole mass estimators for a sample of nineteen AGNs at this redshift. We compare popular recipes available from the literature, finding that mass estimates can differ up to 0.38+-0.05 dex in the mean (or 0.13+-0.05 dex, if the same virial coefficient is adopted). Finally, we provide a set of 30 internally self consistent recipes for determining black hole mass from a variety of observables. The intrinsic scatter between cross-calibrated recipes is in the range 0.1-0.3 dex. This should be considered as a lower limit to the uncertainty of the black hole mass estimators.Comment: ApJ in press, 11 pages, 10 figure

Evaluasi Jumlah Alat Gali-muat Dan Alat Angkut Serta Perhitungan Bahan Bakar Untuk Memproduksi 300.000 Ton/bulan Batu Granit Di PT. Trimegah Perkasa Utama Kepulauan Riau

Berkembangnya industri pembangunan sekarang ini menyebabkan naiknya permintaan konsumen terhadap batu granit sebagai bahan galian industri. Oleh karena itu produsen batu granit terus menerus meningkatkan produksinya. PT. Trimegah Perkasa Utama sebagai produsen terbesar batu granit di Kepulauan Karimun menargetkan produksi sebesar 300.000 ton/bulan batu granit menggunakan 2 unit alat gali-muat dan 8 unit alat angkut dengan total waktu 20 jam pada 2 shift kerja. Dari hasil pengamatan, didapatkan jumlah produksi sebesar 222.897 ton/bulan dengan waktu efektif kerja sebesar 13,96 jam/hari, sedangkan target produksi yang telah ditetapkan oleh Perusahaan sebesar 300.000 ton/bulan. Oleh karena itu perlu dilakukan evaluasi jumlah alat mekanis yang digunakan untuk memproduksi batu granit dan mengetahui faktor-faktor yang mempengaruhi efektifitas kerja. Hasil perhitungan produktivitas setelah dilakukan upaya peningkatan waktu kerja sebesar 15,96 jam/hari dan penambahan alat sebanyak 1 unit alat gali-muat dan 2 unit alat angkut diperoleh produktivitas sebesar 322.294 ton/bulan batu granit

The UV Continuum of Quasars: Models and SDSS Spectral Slopes

We measure long (2200-4000 ang) and short (1450-2200 ang) wavelength spectral slopes \alpha (F_\nu proportional to \nu^\alpha) for quasar spectra from the Sloan Digital Sky Survey. The long and short wavelength slopes are computed from 3646 and 2706 quasars with redshifts in the z=0.76-1.26 and z=1.67-2.07 ranges, respectively. We calculate mean slopes after binning the data by monochromatic luminosity at 2200 ang and virial mass estimates based on measurements of the MgII line width and 3000 ang continuum luminosity. We find little evidence for mass dependent variations in the mean slopes, but a significant luminosity dependent trend in the near UV spectral slopes is observed with larger (bluer) slopes at higher luminosities. The far UV slopes show no clear variation with luminosity and are generally lower (redder) than the near UV slopes at comparable luminosities, suggesting a slightly concave quasar continuum shape. We compare these results with Monte Carlo distributions of slopes computed from models of thin accretion disks, accounting for uncertainties in the mass estimates. The model slopes produce mass dependent trends which are larger than observed, though this conclusion is sensitive to the assumed uncertainties in the mass estimates. The model slopes are also generally bluer than observed, and we argue that reddening by dust intrinsic to the source or host galaxy may account for much of the discrepancy.Comment: To be published in ApJ, 18 pages, 10 figure

AGN Black Hole Masses and Bolometric Luminosities

Black hole mass, along with mass accretion rate, is a fundamental property of active galactic nuclei. Black hole mass sets an approximate upper limit to AGN energetics via the Eddington limit. We collect and compare all AGN black hole mass estimates from the literature; these 177 masses are mostly based on the virial assumption for the broad emission lines, with the broad-line region size determined from either reverberation mapping or optical luminosity. We introduce 200 additional black hole mass estimates based on properties of the host galaxy bulges, using either the observed stellar velocity dispersion or using the fundamental plane relation to infer $\sigma$; these methods assume that AGN hosts are normal galaxies. We compare 36 cases for which black hole mass has been generated by different methods and find, for individual objects, a scatter as high as a couple of orders of magnitude. The less direct the method, the larger the discrepancy with other estimates, probably due to the large scatter in the underlying correlations assumed. Using published fluxes, we calculate bolometric luminosities for 234 AGNs and investigate the relation between black hole mass and luminosity. In contrast to other studies, we find no significant correlation of black hole mass with luminosity, other than those induced by circular reasoning in the estimation of black hole mass. The Eddington limit defines an approximate upper envelope to the distribution of luminosities, but the lower envelope depends entirely on the sample of AGN included. For any given black hole mass, there is a range in Eddington ratio of up to three orders of magnitude.Comment: 43 pages with 10 figures. Accepted for publication in Ap

Lingulodinium machaerophorum expansion over the last centuries in the Caspian Sea reflects global warming

This article is made available through the Brunel Open Access Publishing Fund. Copyright @ Author(s) 2012. This work is distributed under the Creative Commons Attribution 3.0 License.We analysed dinoflagellate cyst assemblages in four short sediment cores, two of them dated by radionuclides, taken in the south basin of the Caspian Sea. The interpretation of the four sequences is supported by a collection of 27 lagoonal or marine surface sediment samples. A sharp increase in the biomass of the dinocyst occurs after 1967, especially owing to Lingulodinium machaerophorum. Considering nine other cores covering parts or the whole of Holocene, this species started to develop in the Caspian Sea only during the last three millennia. By analysing instrumental data and collating existing reconstructions of sea level changes over the last few millennia, we show that the main forcing of the increase of L. machaerophorum percentages and of the recent dinocyst abundance is global climate change, especially sea surface temperature increase. Sea level fluctuations likely have a minor impact. We argue that the Caspian Sea has entered the Anthropocene

No significant association of type 2 diabetes-related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives

AIM: To explore the added value of diabetes-related genetic risk scores (GRSs) to readily available clinical variables in the prediction of glycated haemoglobin (HbA1c) levels after initiation of glucose-regulating drugs. MATERIALS AND METHODS: We conducted a cohort study in people with type 2 diabetes (T2DM) from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database who initiated metformin (MET) or sulphonylurea derivatives (SUs) and for whom blood samples were genotyped. The primary outcome was HbA1c level at 6 months, adjusted for baseline HbA1c. GRSs were based on single nucleotide polymorphisms linked to insulin sensitivity, β-cell activity, and T2DM risk in general. Associations were analysed using multiple linear regression to assess whether adding the GRSs increased the explained variance in a prediction model that included age, gender, diabetes duration and cardio-metabolic biomarkers. RESULTS: We included 282 patients initiating MET and 89 patients initiating SUs. In the MET prediction model, diabetes duration of >3 months when starting MET was associated with 2.7-mmol/mol higher HbA1c level. For SUs, no significant clinical predictors were identified. Addition of the GRS linked to insulin sensitivity (for MET), β-cell activity (for SUs) and T2DM risk (for both) to the models did not improve the explained variance significantly (22% without vs. 22% with GRS) for the MET and (14% without vs. 14% with GRS) for the SUs model, respectively. CONCLUSION: This study did not indicate a significant effect of GRS related to T2DM in general or to the drugs' mechanism of action for prediction of inter-individual HbA1c variability in the short term after initiation of MET or SU therapy

Colon polyps in patients with short bowel syndrome before and after teduglutide: post hoc analysis of the STEPS study series

Background & aims: Teduglutide promotes intestinal growth and is approved for the treatment of short bowel syndrome and intestinal failure (SBS-IF). Based on the pharmacologic activity and preclinical findings, teduglutide can potentially induce proliferative colonic mucosal changes. The aim of this study is to report the occurrence of colorectal polyps in adult patients with SBS-IF who received teduglutide in clinical studies conducted to date. Methods: A post hoc analysis of the completed Study of Teduglutide Effectiveness in Parenteral Nutrition-Dependent Short Bowel Syndrome Subjects (STEPS) clinical study series (NCT00798967, EudraCT 2008-006193-15; NCT00930644, EudraCT 2009-011679-65; NCT01560403) evaluated electronic case report form data for baseline colonoscopies (performed before treatment) and for surveillance or end-of-study (performed after treatment with teduglutide 0.05 mg/kg/day for 24 and 36 months) post-exposure procedures. Results: In the STEPS studies, 73 patients treated with teduglutide had a baseline colonoscopy. No post-exposure colonoscopy was scheduled in STEPS. In STEPS-2/3, 50 of 65 patients with remnant colon (77%) underwent a protocol-mandated post-exposure colonoscopy. Colon polyps were reported at baseline in 12% (9/73) of patients and post-exposure in 18% (9/50) of patients. Two had polyps both at baseline and post-exposure. On histology, available for 7 patients, 5 had adenomas (1 serrated, 4 tubular) and none had malignancy or high-grade dysplasia. Conclusion: These data support recommendations for colonoscopic screening before teduglutide therapy and subsequent on-therapy colonoscopic surveillance for patients with SBS-IF. Further studies are required to assess the risk of polyp formation in patients with SBS-IF and the most appropriate colon polyp surveillance strategies