Omnipräsenz und negativer Einfluss von Unterhaltungsmusik

Das vorliegende fast 700 Seiten starke Werk besitzt nach Aussage des Autors und promovierten Musikwissenschaftlers Klaus Miehling Aufklärungscharakter. Dem Leser soll die größtenteils unbewusste Omnipräsenz von so genannter ‚Gewaltmusik’ und deren negative Eigenschaften verdeutlicht werden. Anhand von unzähligen Beispielen und Berichten soll dargelegt werden, dass der Einfluss der Musik grundlegend unterschätzt wird und in engem Zusammenhang mit der immer weiter ansteigenden Kriminalitätsrate, dem Drogenkonsum und der sexuellen Enthemmung steht

The Morphology of Goethe’s Botanical Work

This thesis examines the morphology of Johann Wolfgang von Goethe (1749-1832) through several lenses. The first explores Goethe's morphology as he applied it in his botanical work and supplies an explanation of what Goethe referred to as archetypal phenomena and the archetypal plant. The scope of exploration then broadens to include how Goethe's morphology related to contemporary intellectual trends, in particular Linnaean taxonomy and Kantian Idealism. These contexts serve to situate the development of Goethe's own thinking from his initial formulations of morphology to later variations. The second half of the thesis focuses on contemporary applications of Goethe's ideas in morphology. Natural aesthetics serves as a natural extension. Modern theories of natural aesthetics seek out different justifications for aesthetic experiences arising from engagement with the natural world and this thesis offers Goethe's morphology as an additional possibility. The final chapter looks at The Nature Institute and how it has adopted Goethe's methods and applied them to modern genetics while expanding its scope to include cultural and ethical contexts. Through its presentation, this thesis intends that Goethe's morphology can be applied beyond it usual biological subject matter, including itself

Forms of Life: Goethe’s Impact on Twentieth-Century Anglophone Botany and Morphology

This dissertation examines the impact of the German naturalist and literary figure Johann Wolfgang von Goethe’s ideas on twentieth century Anglophone plant morphology and biology. Goethe interpreted the organ forms of flowering plants as metamorphoses of each other. His literary, historical, and philosophical writings suggest themes of alienation from and disenchantment of the natural world resulting from mathematical and mechanistic scientific interpretations of nature that have lost their connection to the senses. In twentieth-century debates on plant morphology, Goethe’s metamorphosis theory represented the “Old Morphology” that did not fit with the growing phylogenetic interpretation of forms brought about by Darwinism and the emerging Modern Synthesis. Some, like the English botanist Agnes Arber, saw this as a positive feature of Goethe’s and used it as an example of “Pure Morphology” which she stressed should be carried out before any phylogenetic interpretations. Goethe’s themes of alienation and disenchantment appeared as Arber’s interests in morphology expanded into philosophy and mysticism. Despite his critiques against the overuse of mathematics, in the twentieth century Goethe’s morphology was connected with it in two different ways. The Scottish naturalist D’Arcy Thompson extended Goethe’s morphology into a “Science of Form” as a part of his On Growth and Form where he applied physical methods to biological subjects. Thompson’s background in botany was an factor important for his new science. The English Goethean scientists George Adams and Olive Whicher used projective geometry to integrate Goethe’s morphology with the cosmology of the Swiss esoteric philosopher Rudolf Steiner. With Adams and Whicher, themes of alienation and disenchantment found in Goethe appear again.

A conceptual view at microtubule plus end dynamics in neuronal axons

AbstractAxons are the cable-like protrusions of neurons which wire up the nervous system. Polar bundles of microtubules (MTs) constitute their structural backbones and are highways for life-sustaining transport between proximal cell bodies and distal synapses. Any morphogenetic changes of axons during development, plastic rearrangement, regeneration or degeneration depend on dynamic changes of these MT bundles. A key mechanism for implementing such changes is the coordinated polymerisation and depolymerisation at the plus ends of MTs within these bundles. To gain an understanding of how such regulation can be achieved at the cellular level, we provide here an integrated overview of the extensive knowledge we have about the molecular mechanisms regulating MT de/polymerisation. We first summarise insights gained from work in vitro, then describe the machinery which supplies the essential tubulin building blocks, the protein complexes associating with MT plus ends, and MT shaft-based mechanisms that influence plus end dynamics. We briefly summarise the contribution of MT plus end dynamics to important cellular functions in axons, and conclude by discussing the challenges and potential strategies of integrating the existing molecular knowledge into conceptual understanding at the level of axons

Trustworthy Autonomous Vehicles: Let us Learn from Live

Identifying an general understanding of Trust in Systems Engineering in an interdisciplinary approach. Application domain is autonomous vehicles

Drosophila Short stop as a paradigm for the role and regulation of spectraplakins

Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin genes encode at least 7 characteristic functional domains which are combined in a modular fashion into multiple isoforms, and which are responsible for an enormous breadth of cellular functions. These functions are related to the regulation of actin, microtubules, intermediate filaments, intracellular organelles, cell adhesions and signalling processes during the development and maintenance of a wide variety of tissues. To gain a deeper understanding of this enormous functional diversity, invertebrate genetic model organisms, such as the fruit fly Drosophila, can be used to develop concepts and mechanistic paradigms that can inform the investigation in higher animals or humans. Here we provide a comprehensive overview of our current knowledge of the Drosophila spectraplakin Short stop (Shot). We describe its functional domains and isoforms and compare them with those of the mammalian spectraplakins dystonin and MACF1. We then summarise its roles during the development and maintenance of the nervous system, epithelia, oocytes and muscles, taking care to compare and contrast mechanistic insights across these functions in the fly, but especially also with related functions of dystonin and MACF1 in mostly mammalian contexts. We hope that this review will improve the wider appreciation of how work on Drosophila Shot can be used as an efficient strategy to promote the fundamental concepts and mechanisms that underpin spectraplakin functions, with important implications for biomedical research into human disease

Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons

The formation and maintenance of microtubules requires their polymerisation, but little is known about how this polymerisation is regulated in cells. Focussing on the essential microtubule bundles in axons of Drosophila and Xenopus neurons, we show that the plus-end scaffold Eb1, the polymerase XMAP215/Msps and the lattice-binder Tau co-operate interdependently to promote microtubule polymerisation and bundle organisation during axon development and maintenance. Eb1 and XMAP215/Msps promote each other's localisation at polymerising microtubule plus-ends. Tau outcompetes Eb1-binding along microtubule lattices, thus preventing depletion of Eb1 tip pools. The three factors genetically interact and show shared mutant phenotypes: reductions in axon growth, comet sizes, comet numbers and comet velocities, as well as prominent deterioration of parallel microtubule bundles into disorganised curled conformations. This microtubule curling is caused by Eb1 plus-end depletion which impairs spectraplakin-mediated guidance of extending microtubules into parallel bundles. Our demonstration that Eb1, XMAP215/Msps and Tau co-operate during the regulation of microtubule polymerisation and bundle organisation, offers new conceptual explanations for developmental and degenerative axon pathologies

A novel mitochondrial ATP6 frameshift mutation causing isolated complex V deficiency, ataxia and encephalomyopathy

We describe a novel frameshift mutation in the mitochondrial ATP6 gene in a 4-year-old girl associated with ataxia, microcephaly, developmental delay and intellectual disability. A heteroplasmic frameshift mutation in the MT-ATP6 gene was confirmed in the patient's skeletal muscle and blood. The mutation was not detectable in the mother's DNA extracted from blood or buccal cells. Enzymatic and oxymetric analysis of the mitochondrial respiratory system in the patients' skeletal muscle and skin fibroblasts demonstrated an isolated complex V deficiency. Native PAGE with subsequent immunoblotting for complex V revealed impaired complex V assembly and accumulation of ATPase subcomplexes. Whilst northern blotting confirmed equal presence of ATP8/6 mRNA, metabolic S-35-labelling of mitochondrial translation products showed a severe depletion of the ATP6 protein together with aberrant translation product accumulation. In conclusion, this novel isolated complex V defect expands the clinical and genetic spectrum of mitochondrial defects of complex V deficiency. Furthermore, this work confirms the benefit of native PAGE as an additional diagnostic method for the identification of OXPHOS defects, as the presence of complex V subcomplexes is associated with pathogenic mutations of mtDNA. (C) 2017 Elsevier Masson SAS. All rights reserved.Peer reviewe