Topological phase due to electric dipole moment and magnetic monopole interaction

We show that there is an anologous Aharonov-Casher effect on a neutral particle with electric dipole moment interacting with a magnetic filed produced by magnetic monopoles.Comment: 8 page

Effects of Anomalous Magnetic Moment in the Quantum Motion of Neutral Particle in Magnetic and Electric Fields Produced by a Linear Source in a Conical Spacetime

In this paper we analyse the effect of the anomalous magnetic moment on the non-relativistic quantum motion of a neutral particle in magnetic and electric fields produced by linear sources of constant current and charge density, respectively.Comment: 17 pages, no figur

Relativistic wave equations for interacting massive particles with arbitrary half-intreger spins

New formulation of relativistic wave equations (RWE) for massive particles with arbitrary half-integer spins s interacting with external electromagnetic fields are proposed. They are based on wave functions which are irreducible tensors of rank $n ($n=s-\frac12$) antisymmetric w.r.t. n pairs of indices, whose components are bispinors. The form of RWE is straightforward and free of inconsistencies associated with the other approaches to equations describing interacting higher spin particles

Hall-conductivity sign change and fluctuations in amorphous Nbx_{x}Ge1−x_{1-x} films

The sign change in the Hall conductivity has been studied in thin amorphous Nb$_{1-x}$Ge$_x (x\approx$0.3) films. By changing the film thickness it is shown that the field at which the sign reversal occurs shifts to lower values (from above to below the mean-field transition field $H_{c2}$) with increasing film thickness. This effect can be understood in terms of a competition between a positive normal and a negative fluctuation contribution to the Hall conductivity.Comment: 5 pages, 4 figures, to appear in Phys. Rev.

Interspecies discrimination of A. fumigatus and siblings A. lentulus and A. felis of the Aspergillus section Fumigati using the AsperGenius® assay

The AsperGenius® assay detects several Aspergillus species and the A. fumigatus Cyp51A mutations TR34/L98H/T289A/Y121F that are associated with azole resistance. We evaluated its contribution in identifying A. lentulus and A. felis, 2 rare but intrinsically azole-resistant sibling species within the Aspergillus section Fumigati. Identification of these species with conventional culture techniques is difficult and time-consuming. The assay was tested on (i) 2 A. lentulus and A. felis strains obtained from biopsy proven invasive aspergillosis and (ii) control A. fumigatus (n=3), A. lentulus (n=6) and A. felis species complex (n=12) strains. The AsperGenius® resistance PCR did not detect the TR34 target in A. lentulus and A. felis in contrast to A. fumigatus. Melting peaks for L98H and Y121F markers differed and those of the Y121F marker were particularly suitable to discriminate the 3 species. In conclusion, the assay can be used to rapidly discriminate A. fumigatus, A. lentulus and A. felis.

Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet Disease

Introduction: The etiology of Behçet's disease (BD) is unknown, but widely considered an excessive T-cell mediated inflammatory response in a genetically susceptible host. Recent genomewide association studies (GWAS) have shown limited number of novel loci-associations. The rarity and unequal distribution of the disease prevalence amongst different ethnic backgrounds have hampered the use of GWAS in cohorts of mixed ethnicity and sufficient sample size. However, novel statistical approaches have now enabled GWAS in admixed cohorts. Methods: We ran a GWAS on 336 BD cases and 5,843 controls. The cases consisted of Western Europeans, Middle Eastern and Turkish individuals. Participants from the Generation R study, a multiethnic birth cohort in Rotterdam, The Netherlands were used as controls. All samples were genotyped and data was combined. Linear regression models were corrected for population stratification using Genomic Principal Components and Linear Mixed Modelling. Meta-analysis was performed on selected results previously published. Results: We identified SNPs associated at genome-wide significant level mapping to the 6p21.33 (HLA) region. In addition to this known signal two potential novel associations on chromosomes 6 and 18 were identified, yet with low minor allele frequencies. Extended metaanalysis reveal a GWS association with the IL12A variant rs17810546 on chromosome 3. Discussion: We demonstrate that new statistical techniques enable GWAS analyses in a limited sized cohort of mixed ethnicity. After implementation, we confirmed the central role of the HLA region in the disease and identified new regions of interest. Moreover, we validated the association of a variant in the IL2A gene by meta-analysis with previous work. These findings enhance our

Kjemisk behandling mot Gyrodactylus salaris i Steinkjervassdragene 2006

Årsliste 2007Kjemisk behandling mot Gyrodactylus salaris i Steinkjervassdraget er gjennomført på oppdrag fra Direktoratet for naturforvalting (DN). Tiltakshaver har vært Fylkesmannen (FM) i Sogn og Fjordane. Behandlingen av Steinkjervassdraget høsten 2006 er en del av en totalbehandling som har som hovedmål å utrydde lakseparasitten G. salaris i regionen. Hensikten med behandlingen i august 2006 var å redusere smitten av G. salaris internt i Steinkjervassdragene og eksternt til nærliggende vassdrag i regionen. Dette ble gjort ved å tilsette surt aluminiumsulfat (AlS) i elvevannet og CFT-L (rotenon) i dammer og sig. Behandlingen foregikk i tidsrommet 21.august-2.september 2006. AlS ble dosert ut i hovedelvene og i de største sidevassdragene. I andre små vannkilder i periferien, som for eksempel små sig og mindre avsnørte dammer ble det brukt CFT-Legumin (rotenon). Under behandlingen ble det dosert ut totalt 2 tonn med aluminium og 11 liter CFT-Legumin (0,3 kg rotenon). Lakseunger infisert med G. salaris ble plassert i kar langs elva og eksponert for behandlet elvevann. Ved behandlingens slutt ble alle lakseungene i karene sjekket for G. salaris. Ingen dødelighet ble registrert og det ble heller ikke funnet G. salaris på noen av fiskene i karene.Direktoratet for naturforvaltning

Rapid Low-Cost Microarray-Based Genotyping for Genetic Screening in Primary Immunodeficiency

Background: Genetic tests for primary immunodeficiency disorders (PIDs) are expensive, time-consuming, and not easily accessible in developing countries. Therefore, we studied the feasibility of a customized single nucleotide variant (SNV) microarray that we developed to detect disease-causing variants and copy number variation (CNV) in patients with PIDs for only 40 Euros. Methods: Probes were custom-designed to genotype 9,415 variants of 277 PID-related genes, and were added to the genome-wide Illumina Global Screening Array (GSA). Data analysis of GSA was performed using Illumina GenomeStudio 2.0, Biodiscovery Nexus 10.0, and R-3.4.4 software. Validation of genotype calling was performed by comparing the GSA with whole-genome sequencing (WGS) data of 56 non-PID controls. DNA samples of 95 clinically diagnosed PID patients, of which 60 patients (63%) had a genetically established diagnosis (by Next-Generation Sequencing (NGS) PID panels or Sanger sequencing), w

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

Therapeutic cell differentiatio