INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology

Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reactions (ADR) have halted many drug development programs. Safety pharmacology has successfully implemented a screening strategy to detect cardiovascular liabilities, but there is room for further refinement. In this setting, we present the INSPIRE project, a European Training Network in safety pharmacology for Early Stage Researchers (ESRs), funded by the European Commission's H2020-MSCA-ITN programme. INSPIRE has recruited 15 ESR fellows that will conduct an individual PhD-research project for a period of 36 months. INSPIRE aims to be complementary to ongoing research initiatives. With this as a goal, an inventory of collaborative research initiatives in safety pharmacology was created and the ESR projects have been designed to be complementary to this roadmap. Overall, INSPIRE aims to improve cardiovascular safety evaluation, either by investigating technological innovations or by adding mechanistic insight in emerging safety concerns, as observed in the field of cardio-oncology. Finally, in addition to its hands-on research pillar, INSPIRE will organize a number of summer schools and workshops that will be open to the wider community as well. In summary, INSPIRE aims to foster both research and training in safety pharmacology and hopes to inspire the future generation of safety scientists

Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Neuroanatomical findings on youth anxiety disorders are notoriously difficult to replicate, small in effect size and have limited clinical relevance. These concerns have prompted a paradigm shift toward highly powered (that is, big data) individual-level inferences, which are data driven, transdiagnostic and neurobiologically informed. Here we built and validated supervised neuroanatomical machine learning models for individual-level inferences, using a case–control design and the largest known neuroimaging database on youth anxiety disorders: the ENIGMA-Anxiety Consortium (N = 3,343; age = 10–25 years; global sites = 32). Modest, yet robust, brain-based classifications were achieved for specific anxiety disorders (panic disorder), but also transdiagnostically for all anxiety disorders when patients were subgrouped according to their sex, medication status and symptom severity (area under the receiver operating characteristic curve, 0.59–0.63). Classifications were driven by neuroanatomical features (cortical thickness, cortical surface area and subcortical volumes) in fronto-striato-limbic and temporoparietal regions. This benchmark study within a large, heterogeneous and multisite sample of youth with anxiety disorders reveals that only modest classification performances can be realistically achieved with machine learning using neuroanatomical data.NWORubicon 019.201SG.022Advanced Behavioural Research MethodsHealth and Well-bein

Transmigrasi di indonesia: hubungan antara transmigrasi dan penduduk asli, dengan titik barat sumatera selatan dan tengah

XVI, 199 hal.: 21 cm; Indek

Pelayaran dan pengaruh kebudayaan Makassar Bugis di Pantai Utara Australiia

Peta Asia Tenggara yang dibuat orang Bugis sekitar tahun 1828 memberi kesan betapa luasnya wilayah pelayaran orang-orang Bugis dan Makassar pada waktu itu hingga ke wilayah Australia Utara dan bertemu dengan Merege ( nama penduduk asli Australia Utara). Buku ini merupakan penerbitan ulang terjemahan karangan Belanda hasil kerjasama LIPI dengan KITLV yang diterbitkan oleh Penerbit Bhratara pada 1970-an. Penerbitan ulang ini dilakukan perubahan penulisan sesuai EYD dan tata tulis yang berlaku. Buku ini merupakan terjemahan studi Prof. A.A. Cendse dan Dr. H.J. Heeeren. Hubungan antara Sulawesi Selatan dan tanah Marege di Australia Utara inilah yang menjadi pokok pembicaraan dari kedua karangan yang sekarang diterbitkan dalam satu judul buku ini

Pelajaran dan pengaruh kebudayaan Makasar-Bugis di Pantai utara Australia

50 p.; 20 cm

Transmigrasi di Indonesia/ Heeren

xv, 208 hal.: bibl.: ill.: ind.; 21 cm

Sputtering in surface conversion negative ion sources

In negative ion surface conversion sources with barium converters sputtering of hydrogenous surface particles is believed to be the dominant negative ion production mechanism. In the work performed at the FOM-Institute ion sputtering is also used as cleaning and diagnostic tool. This paper will review the work related to the sputtering mechanisms applied in the FOM surface conversion experiment over the last years. It will be shown that not only sputtering but also direct reflection and prompt rebound sputtering contribute to the negative ion formation on a barium surface