The Circulation of Bronze Mirrors in Late Prehistoric Xinjiang (2000–200 B.C.)

Decades of archaeological excavations have yielded a large number of bronze mirrors from late prehistoric sites in Xinjiang. Scholarly attention has been invested in fitting these specular discs into a singular origin story of the Chinese mirror. Repositioning them within the context of the eastern Eurasian steppe, this article instead takes Xingjiang mirrors as artifacts indexing both diverse local developments and transregional patterns of circulation. A typological framework is proposed based on shape and structure: knob mirror with a flat rim, knob mirror with a flanged rim, grip mirror with a long handle, tanged mirror with a short protrusion, and knobless and handleless mirror. The presence or absence of zoomorphic décor enables even finer distinctions. ArcGIS mapping is employed to investigate the geo-cultural distributions of the different mirror types across Xinjiang. As a result, this article argues that the circulation of bronze mirrors in late prehistoric Xinjiang entailed four aspects of creative processes of cultural exchange, including diversity, fluidity, connectivity, and adaptability. Diversity is manifest in the richness and variety of Xinjiang mirror types. Fluidity challenges the knob-versus-grip dichotomy long held in academia. Connectivity captures frequent and multiple exchanges across all parts of the steppe that generated pan-regional styles and facilitated transfer of mirror casting techniques and designs. Adaptability foregrounds the agency of local invention and adaptation. The combined local-global perspective brings into focus the intricacies of mirror circulation centered in Xinjiang, a pivotal geographic and cultural hub of East-West exchange long before the Han empire’s opening of the Silk Road in the second century B.C

Complex fuzzy linear systems

In paper the complex fuzzy linear equation nbspnbspin which nbspis a crisp complex matrix and nbspis an arbitrary complex fuzzy numbers vector, is investigated. The complex fuzzy linear system is converted to a equivalent high order fuzzy linear system . Numerical procedure for calculating the complex fuzzy solution is designed and thenbsp sufficient condition for the existence of strong complex fuzzy solution is derived. A example is given to illustrate the proposed method.nbs

Modeling the Perceptions and Preferences of Pedestrians on Crossing Facilities

Pedestrian’s street-crossing behaviour has a significant effect on traffic performance and safety. The crossing behaviour is determined by human factors and environmental factors. Aiming at examining the pedestrian perceptions toward crossing facilities and preferences for crossing locations, an observational study of pedestrian crossing behaviour at urban street is conducted. The perceptions and preferences of pedestrians are collected using stated preference technique. A specific questionnaire is designed to conduct the stated preference survey. A multinomial logit model is proposed to describe the perceptions and preferences of pedestrians on crossing facilities and locations. The sensitivity analysis is performed to discuss the influence of various factors on crossing behaviour. Then the relationship between crossing locations and crossing distances is analyzed by a new proposed method. With the theoretical analysis, the engineering solutions considering pedestrian behaviour are suggested. The results are helpful to design human-centered crossing facilities in urban traffic

A Missing Key to Understand the Electrical Resonance and the Mechanical Property of Neurons: a Channel-Membrane Interaction Mechanism

The recent study of the interaction between the fatty acyl tails of lipids and the K+ channel establishes the connection between flexoelectricity and the ion channel's dynamics, named Channel-Membrane Interaction (CMI), that may solve the electrical resonance in neurons

Exceptional point-based ultrasensitive surface acoustic wave gas sensor

Exceptional points (EPs) refer to degeneracies in non-Hermitian systems where two or more eigenvalues and their corresponding eigenvectors coalesce. Recently, there has been growing interest in harnessing EPs to enhance the responsivity of sensors. Significant improvements in the sensitivity of sensors in optics and electronics have been developed. In this work, we present a novel ultrasensitive surface acoustic wave (SAW) gas sensor based on EP. We demonstrate its ability to significantly respond to trace amount of hydrogen sulfide (H2S) gas by tuning additional loss to approach the EP, thereby enhancing the responsivity compared to the conventional delay line gas sensors. In addition to high sensitivity, our sensor is robust to temperature variation and exclusive to H2S gas. We propose an innovative method for designing a new generation of ultrasensitive gas sensor

Synthesis of <i>N</i>-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles enabling PKBβ/AKT2 inhibitory and <i>in vitro</i> anti-glioma activity

A series of N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles was synthesised and screened for their potential to inhibit kinases and exhibit anticancer activity against primary patient-derived glioblastoma 2D cells and 3D neurospheres. A collection of 10 compounds was evaluated against glioma cell lines, with compound 4j exhibiting promising glioma growth inhibitory properties. Compound 4j was screened against 139 purified kinases and exhibited low micromolar activity against kinase AKT2/PKBβ. AKT signalling is one of the main oncogenic pathways in glioma and is often targeted for novel therapeutics. Indeed, AKT2 levels correlated with glioma malignancy and poorer patient survival. Compound 4j inhibited the 3D neurosphere formation in primary patient-derived glioma stem cells and exhibited potent EC(50) against glioblastoma cell lines. Although exhibiting potency against glioma cells, 4j exhibited significantly less cytotoxicity against non-cancerous cells even at fourfold–fivefold the concentration. Herein we establish a novel biochemical kinase inhibitory function for N-(4-chlorophenyl) substituted pyrano[2,3-c]pyrazoles and further report their anti-glioma activity in vitro KEY MESSAGE: Anti-glioma pyrano[2,3-c]pyrazole 4j inhibited the 3D neurosphere formation in primary patient-derived glioma stem cells. 4j also displayed PKBβ/AKT2 inhibitory activity. 4j is nontoxic towards non-cancerous cells

Ecological Assessment of Water Environment in Huizhou Region of China Based on DPSIR Theory and Entropy Weight TOPSIS Model

The ecological security of the water environment is a key element in evaluating the dynamic balance and ecological service functions in the construction of urban ecological civilizations. Through the regional study of water resources in Huizhou, we selected 24 indicators in five dimensions of the DPSIR theory, such as “driving force-pressure-state-impact-response”, and constructed an ecological evaluation index system of the water environment. Combined with the entropy weight TOPSIS model, the analysis was carried out for spatial differentiation features and spatio-temporal deduction features, and the results showed that the weight coefficients of the spatial differentiation features for the guideline layer exhibited significant stratification characteristics. The overall spatial and temporal interpretation characteristics of the water’s environmental ecology in the Huizhou region from 2016 to 2021 showed a pull-up enhancement effect. The relative proximity value showed a 63.43% increase from 0.361 in 2016 to 0.590 in 2021 over the six-year period. The region is characterized by regional differences in the ecological carrying capacity of the water environment, which is high in the south-east and low in the north-west. The top three areas in the quantitative calculation of the ecological carrying capacity of the water environment are Shexian County, Jixi County, and Qimen County, in that order

PO-099 Effects of long-term high-intensity exercise training on renal local renin-angiotensin system in rats

Objective Exercise stimulation to the body of the first stress: blood changes, regulated by the renin-angiotensin system. Long-term high-intensity exercise training will lead to changes in kidney structure and function, resulting in renal injury. This will not only affect training and competition, but also affect the health of athletes, thus it is becoming an influential factor in the occurrence and development of excessive fatigue. At present, the mechanism of renal injury and proteinuria caused by exercise is not very clear. Therefore, this study conducted an in-depth study on the upstream mechanism of renal blood flow changes from the molecular level and explored the effects of 6-week high-intensity exercise training on the renal local renin-angiotensin system in rats. Methods 30 SD male rats (8 weeks old) were randomly divided into control group (10) and exercise group (20). Then according to different time, the exercise group (20) was divided into two groups on average, which are 0h group and 24h group. The rats in the control group did not do any exercise, and the rats in the exercise group were trained to run on the platform with high intensity for 6 weeks. At the beginning of the sixth week, the urine of rats from different group were selected randomly, and the urine NGAL, urinary microalbumin (mAlb), urinary creatinine (UCr) and total urine protein (TP) were tested, to determine the rat model of exercise-induced renal injury with proteinuria. After training on the 6th weekend, the renal tissue renin activity and angiotensin Ⅱ (Ang Ⅱ) content in right kidney were tested. At the same time, the left kidney of the rat was taken to make HE staining sections. Results (1) The mAlb, Alb/Cr and TP of the exercise group were higher than those of the control group, while the UCr content was lower than that of the control group. There was a significant difference between mAlb and TP in the exercise group and the control group(p&lt;0.05). UCr, mAlb/Cr were significantly different from the control group(p&lt;0.01). The urine NGAL concentration in the exercise group was higher than that in the control group, and the difference was significant(p&lt;0.05). (2) The glomerulus of the rats in the 0h group showed obvious congestion, swelling and erythrocyte exudation. The tissue morphology of rats in the 24h group recovered slightly, but it was still different from the control group. (3) The renin activity and Ang Ⅱ were the lowest in the 0h group, and the renin activity and Ang Ⅱ were highest in the 24h group. There is a very significant difference between the groups(p&lt;0.01). Conclusions (1) The 6-week high-intensity training used in this study increased the levels of NGAL, TP, and mAlb in the urine of rats, and successfully established a rat model of exercise-induced renal injury with proteinuria. (2) Long-term high-intensity exercise training can cause obvious congestion, swelling, erythrocyte exudation in rat glomeruli, which can’t return to the quiet level 24 hours after exercise. (3) Renal injury caused by exercise decreased the expression of local renin activity and angiotensin II in the kidney, and the recovery of renal renin activity and angiotensin II was increased 24h after exercise