Endoscopic early detection of premalignant changes in stomach with mucosal biopsy in patients with symptomatology of acid peptic disease

Background: Stomach cancer is the second-most common cancer among men and third-most among females in Asia and worldwide. The symptoms and sign of the stomach cancer are often reported late when the disease is already in advanced stages and 5-year survival is less than 30% in developed countries and around 20% in developing countries. Early detection of cancer stomach is still remains challenge to the gastroenterologist.Methods: This study was done to detect early premalignant changes by upper GI scopy and histopathological examinations of mucosal biopsies in patients with symptoms of acid peptic disease not responding to any type of medications. 200 patients above 20 years of age with acid peptic disease symptoms selected for upper GI scopy and histopathology with follow up from 6 months to two years to detect whether premalignant lesion changes to malignancy.Results: Different types of inflammatory lesions of gastric mucosa detected endoscopically and on histopathology in our study. In 7 patients premalignant changes were detected and 7 patients already had gross malignancies in stomach. Out of the total number of biopsies included in the study, we observed lesions of atrophic type in 4 antral biopsies (2.25%) and 3 biopsies of the gastric body (1.69%). All were grade 1 as per Sydney classification.Conclusions: Upper endoscopy with histopathology has excellent output to detect early premalignant changes in stomach mucosa, though it is long way to continue this study to correlate both

A rare case of tubeculous mesenteric cyst

We report a case of 17 year old female weighing 85 kg with chronic abdominal pain. Radiological imaging techniques revealed it as an enteric duplication cyst or mesenteric cyst. Diagnostic laparoscopy confirmed the cyst originating from mesentery. After laparoscopic excision of this cyst histopathology report was unusual, as a tuberculous mesenteric cyst

Intussusception due to caecal carcinoma in a young man: unusual cause of presentation a case report

A young 26 year male patient admitted with colicky pain in right iliac fossa with well palpable tender lump. After radiological investigation lump was diagnosed as ileocaecal intussusception. Patient underwent laparoscopy which diagnosed as intussusception due to caecal carcinoma. Laparoscopy again proved to be useful diagnostic tool over imaging techniques in this case. Laparoscopic assisted surgery of right radical hemicolectomy done successfully

A rare case of Bochdalek diaphragmatic hernia with concomitant partial situs inversus

Congenital diaphragmatic hernias clinically presenting in adulthood are exceedingly rare lesions, mainly left-sided defect (Bochdalek). Bochdalek hernias most commonly manifest during the patient’s first few weeks of life. Diagnosis beyond the first 8 weeks of life is estimated to represent 5-25% of all Bochdalek hernias. Here we have a 32 year old female patient who presented with 10x10 cm diaphragmatic hernia with dextrocardia who was asymptomatic for years

Role of vacuum assisted closure therapy in chronic wounds: for some cases in Navi Mumbai

Background: This study was performed to evaluate the results of vacuum assisted wound therapy in patients with chronic non healing ulcer.Methods: The study was conducted in the department of General Surgery at a tertiary care hospital. It was an observational study with prospective design. The role of NPWT in various wounds was studied in 10 patients.Results: Out of 10 wounds taken in the study, 7 wounds  reduced  in  area  & were  resurfaced with Split thickness skin  grafting and 3 wounds  showed  reduction in area & were subjected to secondary closure.Conclusions: Vacuum assisted closure (VAC) therapy provides sterile and controlled environment to large, exudating wound  surfaces and is  treatment  of  choice  in  infected / non – healing wounds,  not  responding  to  standard  treatment

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Endoscopic early detection of premalignant changes in stomach with mucosal biopsy in patients with symptomatology of acid peptic disease

Background: Stomach cancer is the second-most common cancer among men and third-most among females in Asia and worldwide. The symptoms and sign of the stomach cancer are often reported late when the disease is already in advanced stages and 5-year survival is less than 30% in developed countries and around 20% in developing countries. Early detection of cancer stomach is still remains challenge to the gastroenterologist.Methods: This study was done to detect early premalignant changes by upper GI scopy and histopathological examinations of mucosal biopsies in patients with symptoms of acid peptic disease not responding to any type of medications. 200 patients above 20 years of age with acid peptic disease symptoms selected for upper GI scopy and histopathology with follow up from 6 months to two years to detect whether premalignant lesion changes to malignancy.Results: Different types of inflammatory lesions of gastric mucosa detected endoscopically and on histopathology in our study. In 7 patients premalignant changes were detected and 7 patients already had gross malignancies in stomach. Out of the total number of biopsies included in the study, we observed lesions of atrophic type in 4 antral biopsies (2.25%) and 3 biopsies of the gastric body (1.69%). All were grade 1 as per Sydney classification.Conclusions: Upper endoscopy with histopathology has excellent output to detect early premalignant changes in stomach mucosa, though it is long way to continue this study to correlate both