How do cardiologists select patients for dual antiplatelet therapy continuation beyond 1 year after a myocardial infarction? Insights from the EYESHOT Post-MI Study

Background: Current guidelines suggest to consider dual antiplatelet therapy (DAPT) continuation for longer than 12 months in selected patients with myocardial infarction (MI). Hypothesis: We sought to assess the criteria used by cardiologists in daily practice to select patients with a history of MI eligible for DAPT continuation beyond 1 year. Methods: We analyzed data from the EYESHOT Post-MI, a prospective, observational, nationwide study aimed to evaluate the management of patients presenting to cardiologists 1 to 3 years from the last MI event. Results: Out of the 1633 post-MI patients enrolled in the study between March and December 2017, 557 (34.1%) were on DAPT at the time of enrolment, and 450 (27.6%) were prescribed DAPT after cardiologist assessment. At multivariate analyses, a percutaneous coronary intervention (PCI) with multiple stents and the presence of peripheral artery disease (PAD) resulted as independent predictors of DAPT continuation, while atrial fibrillation was the only independent predictor of DAPT interruption for patients both at the second and the third year from MI at enrolment and the time of discharge/end of the visit. Conclusions: Risk scores recommended by current guidelines for guiding decisions on DAPT duration are underused and misused in clinical practice. A PCI with multiple stents and a history of PAD resulted as the clinical variables more frequently associated with DAPT continuation beyond 1 year from the index MI

Global thermal models of the lithosphere

Unravelling the thermal structure of the outermost shell of our planet is key for understanding its evolution.We obtain temperatures from interpretation of global shear-velocity (VS) models. Long-wavelength thermal structure is well determined by seismic models and only slightly affected by compositional effects and uncertainties in mineral-physics properties. Absolute temperatures and gradients with depth, however, are not well constrained. Adding constraints from petrology, heat-flow observations and thermal evolution of oceanic lithosphere helps to better estimate absolute temperatures in the top part of the lithosphere. We produce global thermal models of the lithosphere at different spatial resolution, up to spherical-harmonics degree 24, and provide estimated standard deviations. All relevant physical properties, with the exception of thermal conductivity, are based on a self-consistent thermodynamical modelling approach. Our global thermal models also include density and compressional-wave velocities (VP) as obtained either assuming no lateral variations in composition or a simple reference 3-D compositional structure, which takes into account a chemically depleted continental lithosphere. The global thermal models should serve as the basis to move at a smaller spatial scale, where additional thermo-chemical variations required by geophysical observations can be included

LitMod3D_v3.0: a software for integrated geophysical-petrological thermochemical modelling of lithosphere

Contacto: Fullea Javier, [email protected] Contacto: Eldar Baykiev, [email protected] is a software for 3D integrated geophysical-petrological interactive modelling of the lithosphere and underlying upper mantle using a variety of input datasets: potential fields (gravity and magnetic), surface heat flow, elevation (isostasy), seismics, magnetotellurics and geochemical. Ver 3.0 incorporates a highly optimised Python thermal solver (bi-conjugate gradient squared method), crustal petrology features (thermodynamic equilibrium and metastable) and a parallel gravity forward solver. The new version is intended to work with program get-inp (customized interface to Perple_X, http://www.perplex.ethz.ch/) to generate the inputcrustal and mantle compositional files. This software was first edited in 2009 and updated in 2019.Ministerio de Educación y Ciencia, Formación Profesorado Universitario; Ministerio de Ciencia e Innovación CSD2006-00041 Consolider-Ingenio 2010 Program TopoIberiaPeer reviewe

LitMod3D_v4.0: a software for integrated geophysical-petrological thermochemical modelling of lithosphere

Contacto: Fullea Javier, [email protected] Contacto: Eldar Baykiev, [email protected] is a software for 3D integrated geophysical-petrological interactive modelling of the lithosphere and underlying upper mantle using a variety of input datasets: potential fields (gravity and magnetic), surface heat flow, elevation (isostasy), seismics, magnetotellurics and geochemical. Ver 3.0 incorporates a highly optimised Python thermal solver (bi-conjugate gradient squared method), crustal petrology features (thermodynamic equilibrium and metastable) and a parallel gravity forward solver. The new version is intended to work with program get-inp (customized interface to Perple_X, http://www.perplex.ethz.ch/) to generate the inputcrustal and mantle compositional files. Ver 4.0 has a built-in dispersion-curves calculator. This software was first edited in 2009 and updated in 2019.Ministerio de Educación y Ciencia, Formación Profesorado Universitario; Ministerio de Ciencia e Innovación, CSD2006-00041 Consolider-Ingenio 2010 Program TopoIberiaPeer reviewe