The Dutch Observatory on Employment and Training

Not availableeducation, training and the labour market;

Skills Obsolescence: Causes and Cures

Until now there has been surprisingly little research on the causes of and the remedies for skills obsolescence. This study tries to fill that gap to some extent by analysing the relation between risk factors and skills obsolescence. Moreover, the role remedies play to counter skills obsolescence is analysed. Four empirical analyses that relate skills obsolescence to risk factors and remedies are presented. We find that most risk factors identified in the literature can be validated empirically. The remedies for skills obsolescence are not effective in all situations: the results show that there is considerable variation in the effectiveness of the remedies across different types of skills obsolescence. Although current available data does not allow a comprehensive analysis, which also takes account of relations between the various types of skills obsolescence, the results obtained are plausible and offer a starting point for further research.education, training and the labour market;

Methodiek werkgelegenheid en scholing 1996

not availableeducation, training and the labour market;

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines

The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children. Responding to this mandate, five FP7 project calls were launched and 20 projects were granted. This paper aims to detail the funded projects and their preliminary results. Publicly available sources have been consulted and a descriptive analysis has been performed. Twenty Research Consortia including 246 partners in 29 European and non-European countries were created (involving 129 universities or public funded research organisations, 51 private companies with 40 SMEs, 7 patient associations). The funded projects investigate 24 medicines, covering 10 therapeutic areas in all paediatric age groups. In response to the Paediatric Regulation and to apply for a Paediatric Use Marketing Authorisation, 15 Paediatric Investigation Plans have been granted by the EMAPaediatric Committee, including 71 studies of whom 29 paediatric clinical trials, leading to a total of 7,300 children to be recruited in more than 380 investigational centres. Conclusion: Notwithstanding the EU contribution for each study is lower than similar publicly funded projects, and also considering the complexity of paediatric research, these projects are performing high-quality research and are progressing towards the increase of new paediatric medicines on the market. Private–public partnerships have been effectively implemented, providing a good example for future collaborative actions. Since these projects cover a limited number of offpatent drugs and many unmet therapeutic needs in paediatrics remain, it is crucial foreseeing new similar initiatives in forthcoming European funding programmes

Light sensitivity in a vertebrate mechanoreceptor?

Using immunohistochemistry and Western blot analysis we demonstrate that melanopsin is localised in cells around the central pore of lateral line neuromasts in the African clawed frog, Xenopus laevis. Since melanopsin is a known photoreceptor pigment with diverse functions in vertebrates, we suggest that the lateral line of Xenopus laevis, which is primarily a mechanorecptor, may also be light sensitive. Potential functions of such photosensitivity are discussed, including its role in mediating locomotor responses following dermal illumination

Methodiek arbeidsmarktprognoses en -indicatoren 1999-2004

In dit werkdocument wordt een overzicht gegeven van de methodiek die is gehanteerd bij het opstellen van de arbeidsmarktprognoses naar opleiding en beroep tot 2004 en de bijbehorende arbeidsmarktindicatoren ten behoeve van het rapport De arbeidsmarkt naar opleiding en beroep tot 2004 en de bijbehorende Statistische Bijlage. Het ROA brengt deze arbeidsmarktinformatie uit in het kader van het Project Onderwijs - Arbeidsmarkt (POA). De gegevens – die een beeld geven van de arbeidsmarktpositie van opleidingen en beroepen – zijn ook gebruikt door het LDC Expertisecentrum voor loopbaanvraagstukken, onder andere in de publicatie Kansen op werk 2004 en de op CD-ROM verkrijgbare Traject-reeks.education, training and the labour market;