Suppression of Classical and Quantum Radiation Pressure Noise via Electro-Optic Feedback

We present theoretical results that demonstrate a new technique to be used to improve the sensitivity of thermal noise measurements: intra-cavity intensity stabilisation. It is demonstrated that electro-optic feedback can be used to reduce intra-cavity intensity fluctuations, and the consequent radiation pressure fluctuations, by a factor of two below the quantum noise limit. We show that this is achievable in the presence of large classical intensity fluctuations on the incident laser beam. The benefits of this scheme are a consequence of the sub-Poissonian intensity statistics of the field inside a feedback loop, and the quantum non-demolition nature of radiation pressure noise as a readout system for the intra-cavity intensity fluctuations.Comment: 4 pages, 1 figur

Three-Dimensional Magnetohydrodynamics Simulations Of Counter-Helicity Spheromak Merging In The Swarthmore Spheromak Experiment

Recent counter-helicity spheromak merging experiments in the Swarthmore Spheromak Experiment (SSX) have produced a novel compact torus (CT) with unusual features. These include a persistent antisymmetric toroidal magnetic field profile and a slow, nonlinear emergence of the n = 1 tilt mode. Experimental measurements are inconclusive as to whether this unique CT is a fully merged field-reversed configuration (FRC) with strong toroidal field or a partially merged doublet CT configuration with both spheromak- and FRC-like characteristics. In this paper, the SSX merging process is studied in detail using three-dimensional resistive MHD simulations from the Hybrid Magnetohydrodynamics (HYM) code. These simulations show that merging plasmas in the SSX parameter regime only partially reconnect, leaving behind a doublet CT rather than an FRC. Through direct comparisons, we show that the magnetic structure in the simulations is highly consistent with the SSX experimental observations. We also find that the n = 1 tilt mode begins as a fast growing linear mode that evolves into a slower-growing nonlinear mode before being detected experimentally. A simulation parameter scan over resistivity, viscosity, and line-tying shows that these parameters can strongly affect the behavior of both the merging process and the tilt mode. In fact, merging in certain parameter regimes is found to produce a toroidal-field-free FRC rather than a doublet CT. (C) 2011 American Institute of Physics. [doi:10.1063/1.3660533

Spectroscopic Observation Of Simultaneous Bi-Directional Reconnection Outflows In A Laboratory Plasma

We report a precise, direct spectroscopic measurement of simultaneous bi-directional outflows from a reconnection event in a laboratory plasma. Outflow speeds are as Alfvenic and Abel analysis shows that the outflows are generated in the plasma core. A Sweet-Parker like analysis of outflow speed coupled with external measurements of reconnection electric field and assumption of Spitzer resistivity predict an aspect ratio of the reconnection layer and reconnection rate that are close to that measured in the experiment and in simulations. However, this analysis underestimates the absolute scale of the layer, indicating other than 2D resistive physics is at play. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4747345

Three-Dimensional Reconnection And Relaxation Of Merging Spheromak Plasmas

Plasma relaxation inside a highly conducting cylindrical boundary is studied both experimentally and computationally. Dynamics are initiated by the introduction of two equal helicity spheromaks at either end of the cylinder. In the experiment, dense, high-magnetic-flux spheromaks are injected into the flux conserving volume with magnetized plasma guns. In the simulation, identical spheromaks initially occupy both halves of the cylinder and a perturbation is introduced. Merging commences with a single three-dimensional null-point that moves radially out of the flux conserving volume at velocities up to 0.2 of the reconnection outflow velocity. Relaxation to the minimum energy state occurs in about ten Alfven times. An important conclusion is that even though the dynamical activity is limited to a few modes, this activity is sufficient to promote relaxation to the final, minimum energy state. The dynamical activity appears to conserve magnetic helicity while magnetic energy is converted to flow and heat. The final state arrived at dynamically is identical to that described by C. D. Cothran et al. [Phys. Rev. Lett. 103, 215002 (2009)] using static, eigenvalue analysis. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3492726

Peak rates of diuresis in healthy humans during oral fluid overload

Objective. To determine whether rates of intestinal fluid absorption and renal diuresis can match high rates of fluid ingestion in healthy humans exposed to oral fluid overload, thereby preventing the development of hyponatraemia either by reverse sodium movement across the intestine (the Priestley-Haldane effect) or by expansion of the extracellular fluid volume.Methods. Changes in renal function and in plasma chemical measurements in response to an oral fluid overload (0.9 - 1.8 1/ h x 3 h) were investigated in 6 healthy control subjects at rest, and in a subject with a history of exercise induced symptomatic hyponatraemia, during both prolonged (160-minute) exercise and at rest.Findings. All control subjects gained weight (2.7 ± 0.2 kg, mean ± standard error of mean (SEM)) because the rate of oral fluid intake exceeded the peak rate of urine production (778 ± 39 rnl / h). Blood volume rose by 7.1 (± 0.5)% and plasma sodium concentrations fell progressively from 144 ± 2.6 to 136 ± 1.1 mmol/ 1 (P < 0.05) in the control subjects. Plasma potassium and angiotensin II concentrations were unchanged and creatinine clearance was normal ( -125 rnl/min). Free water clearance reached a maximum of 11.2 ± 0.9 rnl/min after 2 hours. The increase in body mass could be accounted for by calculated or measured changes in extra- and intracellular fluid volumes. Similar changes were measured in the subject with a previous history of symptomatic hyponatraernia.Conclusion. The rate of intestinal fluid absorption appeared to match the rate of oral fluid ingestion and there was no  evidence of fluid accumulation in the intestine with reverse sodium movement from the extracellular space into intestinal fluid. The results of this study are therefore at variance with the Priestley-Haldane hypothesis and suggest that reverse sodium movement did not contribute to the hyponatraernia induced by oral fluid overload in these subjects. Rather it appears that humans may have a limited capacity to excrete fluid at rates in excess of -900 rnl/ h in response to higher rates of oral fluid intake. When the rate of intestinal fluid absorption matches the rate of fluid ingestion and exceeds the kidneys' maximum capacity for fluid excretion, the excess fluid accumulates in the extra- and intracellular fluid compartments, inducing the dilutional hyponatraemia of water intoxication. These findings may have relevance to other clinical conditions in which hyponatraemia develops in response to high rates of oral or intravenous fluid provision

Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis B

Abstract AIM: To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS: A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was performed. Patients were excluded if they had received previous treatment with another nucleoside or nucleotide analogue, were pregnant or less than 18 years old. RESULTS: Out of 336 patients, 163 patients fulfilled the selection criteria. Range of follow up was 3-46 mo (mean 26 mo). 134 patients (82.2%) had pre-treatment biopsies, with 26 patients (16.0 %) demonstrating F3-4 fibrosis. In total, 153 patients (93.9%) achieved at least Partial Virological Suppression (PVS), with 134 patients (82.2%) achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1% and 96.4%, respectively. 3 patients (1.8%) failed to achieve PVS, while 5 patients (3.0%) developed virological rebound. 128 patients (78.5%) maintained CVS throughout follow up. Predictors of CVS included lower baseline DNA level (P = 0.001), hepatitis B virus e antigen negative status (P = 0.001) and increasing age at treatment (log rank 0.001). No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION: Entecavir monotherapy is efficacious and safe in an Australian tertiary care setting. Resistance and rebound rates are very low. This is similar to data from controlled and uncontrolled trials around the world

Stable Spheromak Formation By Merging In An Oblate Flux Conserver

An axisymmetric spheromak formed by the dynamic merging of two smaller spheromaks of the same magnetic helicity in the Swarthmore Spheromak Experiment (SSX) [M. R. Brown, Phys. Plasmas 6, 1717 (1999)] has been observed and characterized. The spheromak is formed in an oblate (tilt stable), trapezoidal, 6 mm wall copper flux conserver in SSX, which is 0.5 m in diameter and L=0.4 m in length at its largest dimensions. This configuration is formed by cohelicity merging of two spheromaks (either both right-handed or both left-handed) in which the merging poloidal fluxes are parallel (i.e., no field reversal for reconnection to occur initially). After a period of dynamic and nonaxisymmetric activity, the configuration ultimately relaxes to an axisymmetric state. A nonaxisymmetric tilted state, very close in total energy to the axisymmetric state, is also sometimes observed. This configuration is characterized by a suite of magnetic probe arrays for magnetic structure B(r,t), ion Doppler spectroscopy for T(i) and flow, and interferometry for ne. The magnetic structures of both states match well to computed eigenstates. (C) 2010 American Institute of Physics. [doi:10.1063/1.3334324