From bedside to bench: Comroe and dripps revisited

Twenty-five years ago a paper published in Science by Julius Comroe and Robert Dripps purported to demonstrate that 41 per cent of all articles judged to be essential for later clinical advances were not clinically oriented at the time of the study and 62 per cent of key articles were the result of basic research. Since that analysis, support for basic research has increased in the G7 countries. In the UK, Research Council expenditure on basic research has increased from a low of £444 million (or 42 per cent of total civil R&D) in 1991/92 to £769 million (or 61 per cent of total civil R&D) in 1998/99. Although it would be difficult to argue that Comroe and Dripps were directly responsible for a strategic shift (or drift) in the type of science supported by research funders, their arguments are often cited (albeit at times implicitly) in support of the increased funding for basic biomedical research. In 1987 Richard Smith wrote a critical paper reassessing Comroe and Dripps. His main argument was that the original study was in itself ‘unscientific’ and that it should be “followed by bigger and better studies”. This study is, in part, an answer to that challenge. Given the increased support for basic research, and the apparent importance based on the work of Comroe and Dripps, we felt it was important to investigate Smith’s comments by replicating Comroe and Dripps’s study and at the same time try to improve upon the methodology. The current project had two objectives: 1. To see if the original Comroe and Dripps’s methodology was ‘replicable’. 2. To validate the key findings of Comroe and Dripps. By looking at neonatal intensive care (NIC), we concluded that Comroe and Dripps’ study – as reported – is not repeatable, reliable or valid, and thus is an insufficient evidence base for increased expenditure on basic biomedical research. We did, however, develop an alternative methodology which used bibliographic databases and bibliometric techniques to describe the research underpinning five of the most important clinical advances in NIC, as identified through a Delphi survey. Using the revised bibliometric protocol, we demonstrated that after a time-lag of about 17 years, between 2 and 21 per cent of research underpinning the clinical advances could be described as basic. This observation is at odds with Comroe and Dripps’s finding that 62 per cent of key research articles judged to be essential for latter clinical advance were the result of basic research. In reaching this conclusion we are acutely aware of the significant limitations to the revised methodology and, therefore, we caution against the over-interpretation of our results. However, we would argue that there needs to be a greater understanding of how basic research supports healthcare and hope this report will inform part of this wider debate.R&D Directorate of the NHS Executive London; Wellcome Trus

Replaceable filters and cones for flared-tubing connectors

Connector is modified by machining the cone from one end before the fitting is bored to accommodate a metallic-filament type of slip-in filter. Thus, when surface of the cone is damaged, only the cone needs replacement

Remote measurements of ozone, water vapor and liquid water content, and vertical profiles of temperature in the lower troposphere

Several advanced atmospheric remote sensing systems developed at the Jet Propulsion Laboratory were demonstrated under various field conditions to determine how useful they would be for general use by the California Air Resources Board and local air quality districts. One of the instruments reported on is the Laser Absorption Spectrometer (LAS). It has a pair of carbon dioxide lasers with a transmitter and receiver and can be flown in an aircraft to measure the column abundance of such gases as ozone. From an aircraft, it can be used to rapidly survey a large region. The LAS is usually operated from an aircraft, although it can also be used at a fixed location on the ground. Some tests were performed with the LAS to measure ozone over a 2-km horizontal path. Another system reported on is the Microwave Atmospheric Remote Sensing System (MARS). It is tuned to microwave emissions from water vapor, liquid water, and oxygen molecules (for atmospheric temperature). It can measure water vapor and liquid water in the line-of-sight, and can measure the vertical temperature profile

Summary of the electromagnetic compatibility evaluation of the proposed satellite power system

The effects of the proposed solar power satellite (SPS) operations on electronic equipment and systems by fundamental, harmonic, and intermodulation component emissions from the orbital station; and the fundamental, harmonic, and structural intermodulation emissions from the rectenna site were evaluated. The coupling and affects interactions affecting a wide spectrum of electronic equipment are considered. The primary EMC tasking areas are each discussed separately

Using ACIS on the Chandra X-ray Observatory as a particle radiation monitor

The Advanced CCD Imaging Spectrometer (ACIS) is one of two focal-plane instruments on the Chandra X-ray Observatory. During initial radiation-belt passes, the exposed ACIS suffered significant radiation damage from trapped soft protons scattering off the x-ray telescope's mirrors. The primary effect of this damage was to increase the charge-transfer inefficiency (CTI) of the ACIS 8 front-illuminated CCDs. Subsequently, the Chandra team implemented procedures to remove the ACIS from the telescope's focus during high-radiation events: planned protection during radiation-belt transits; autonomous protection triggered by an on-board radiation monitor; and manual intervention based upon assessment of space-weather conditions. However, as Chandra's multilayer insulation ages, elevated temperatures have reduced the effectiveness of the on-board radiation monitor for autonomous protection. Here we investigate using the ACIS CCDs themselves as a radiation monitor. We explore the 10-year database to evaluate the CCDs' response to particle radiation and to compare this response with other radiation data and environment models.Comment: 10 pages, 5 figures. To appear in Proc. SPIE vol. 773

A Trojan Horse for Positivism? A Critique of Mixed Methods Research

Mixed methods research is captured by a pragmatically inflected form of postpositivism. Although it passes for an alternative methodological movement that purports to breach the divide between qualitative and quantitative research, most mixed methods studies favor the forms of analysis and truth finding associated with positivism. We anticipate a move away from exploring more philosophical questions or undertaking modes of enquiry that challenge the status quo. At the same time, we recognize that mixed methods research offers particular strengths and that, although it serves as a Trojan Horse for positivism, it may productively carry other paradigmatic passengers

Model Independent Primordial Power Spectrum from Maxima, Boomerang, and DASI Data

A model-independent determination of the primordial power spectrum of matter density fluctuations could uniquely probe physics of the very early universe, and provide powerful constraints on inflationary models. We parametrize the primordial power spectrum $A_s^2(k)$ as an arbitrary function, and deduce its binned amplitude from the cosmic microwave background radiation anisotropy (CMB) measurements of Maxima, Boomerang, and DASI. We find that for a flat universe with $A_s^2(k)=1$ (scale-invariant) for scales $k<0.001$h/Mpc, the primordial power spectrum is marginally consistent with a scale-invariant Harrison-Zeldovich spectrum. However, we deduce a rise in power compared to a scale-invariant power spectrum for 0.001 h/{Mpc} \la k \la 0.01 h/{Mpc}. Our results are consistent with large-scale structure data, and seem to suggest that the current observational data allow for the possibility of unusual physics in the very early universe.Comment: substantially revised and final version, accepted by Ap