A Cross-National Investigation of the Relationship Between Infant Walking and Language Development

The acquisition of walking has recently been linked with infant language development (Walle & Campos, 2014). If this relation reflects the consequence of an epigenetic event, then it should be present regardless of when the infant typically begins to walk, the infant's culture, and the infant's native language. This study sought to replicate the previously reported link between walking and language development in American infants and investigate whether this relation exists cross-nationally in typically developing Chinese infants exposed to Mandarin. Urban Chinese infants not only provide a distinct linguistic and cultural population in which to study this relation but also typically begin walking approximately 6 weeks later than American infants. Our results demonstrated that (1) walking infants in both the American and Chinese samples had greater receptive and productive vocabularies than same-aged crawling infants, (2) differences between crawling and walking infants were proportionally similar in each sample, and (3) the walking-language relation was present for both noun and non-noun vocabularies. These findings provide further support of a relation between infant walking onset and language development, independent of age. Avenues for future research of the processes involved in this relation, as well as additional populations of interest to investigate, are discussed. Copyrigh

Proximodistal Exploration in Motor Learning as an Emergent Property of Optimization

International audienceTo harness the complexity of their high-dimensional bodies during sensorimotor development , infants are guided by patterns of freezing and freeing of degrees of freedom. For instance, when learning to reach, infants free the degrees of freedom in their arm proximodis-tally, i.e. from joints that are closer to the body to those that are more distant. Here, we formulate and study computationally the hypothesis that such patterns can emerge spontaneously as the result of a family of stochastic optimization processes (evolution strategies with covariance-matrix adaptation), without an innate encoding of a maturational schedule. In particular, we present simulated experiments with an arm where a computational learner progressively acquires reaching skills through adaptive exploration, and we show that a proximodistal organization appears spontaneously, which we denote PDFF (ProximoDistal Freezing and Freeing of degrees of freedom). We also compare this emergent organization between different arm morphologies – from human-like to quite unnatural ones – to study the effect of different kinematic structures on the emergence of PDFF. Research highlights. • We propose a general, domain-independent hypothesis for the developmental organization of freezing and freeing of degrees of freedom observed both in infant development and adult skill acquisition, such as proximo-distal exploration in learning to reach

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

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