Development and validation of a faecal immunochemical test-based model in the work-up of patients with iron deficiency anaemia

ObjectiveIn patients with iron deficiency anaemia (IDA), the diagnostic yield of gastroscopy and colonoscopy (bidirectional endoscopy) in detecting neoplastic lesions is low. This study aimed to develop and validate a faecal immunochemical test (FIT)-based model to optimise the work-up of patients with IDA.MethodsOutpatients with IDA were enrolled in a prospective, multicentre study from April 2016 to October 2019. One FIT was performed before bidirectional endoscopy. Significant gastrointestinal lesions were recorded and a combined model developed with variables that were independently associated with significant colorectal lesions in the multivariate analysis. The model cut-off was selected to provide a sensitivity of at least 95% for colorectal cancer (CRC) detection, and its performance was compared to different FIT cut-offs. The data set was randomly split into two groups (developed and validation cohorts). An online calculator was developed for clinical application.ResultsThe development and validation cohorts included 373 and 160 patients, respectively. The developed model included FIT value, age, and sex. In the development and validation cohorts, a model cut-off of 0.1375 provided a negative predictive value of 98.1 and 96.7% for CRC and 90.7 and 88.3% for significant colorectal lesions, respectively. This combined model reduced the rate of missed significant colorectal lesions compared to FIT alone and could have avoided more than one-fourth of colonoscopies.ConclusionThe FIT-based combined model developed in this study may serve as a useful diagnostic tool to triage IDA patients for early endoscopic referral, resulting in considerable reduction of unnecessary colonoscopies

COMPORTAMIENTO Y CULTURA ORGANIZACIONAL: Un análisis desde la intra e interdisciplinariedad

The eleven chapters of this book detail how to have an impact on companies in different sectors and in specific areas of improvement, commenting by those involved in the project what the great thinkers of management, marketing, production and several more, expose and match it with the focused area of analysis.After the description of the problem or improvement proposal to be implemented, the pertinent literature is compiled; then the methodology to be used to provide results; that, precisely that, is what we most require in the business sector in reference to the linkage with educational institutions and especially at postgraduate levels. This applied research that translates into generating more competitive conditions for the economic units is something truly valuable, since with this the entities involved obtain a value that unfolds towards the community, causing the goods or services to be offered with an added value that would not have been possible without the articulation of both spheres, the business and the academic.En los once capítulos de este libro se nos detalla cómo poder incidir en compañías de diversos giros y en áreas específicas de mejora, comentando por los involucrados en el proyecto lo que los grandes pensadores de la administración, el marketing, la producción y varios más, exponen y lo empatan con el área enfocada de análisis.Posterior a la descripción del problema o propuesta de mejora a implementar, se recopila la literatura pertinente para ello; luego se da paso a la metodología que se utilizará para poder dar resultados; eso, precisamente eso, es lo que más requerimos en el sector empresarial en referencia a la vinculación con las instituciones de educación y sobre todo en niveles de posgrado. Esa investigación aplicada que se traduce en generar condiciones más competitivas para las unidades económicas es algo verdaderamente valioso, ya que con esto los entes involucrados obtienen un valor que se desdobla hacia la comunidad, provocando que los bienes o servicios sean ofrecidos con un agregado de valor que no hubiera sido posible sin la articulación de ambas esferas, la empresarial y la académica

Un acercamiento a la investigación multidisciplinar en la Universidad Autónoma de Aguascalientes

According to the World Health Organization\u27s (WHO) declaration of April 27, 2020, on December 31, 2019, the presence of a new coronavirus was confirmed, causing multiple cases of pneumonia in the city of Wuhan, China. Due to its spread and severity, on March 11, 2020, the WHO declared that a pandemic level had been reached (WHO, 2020). In Mexico, on March 24, 2020, an agreement was published in the Official Journal of the Federation (DOF) to establish preventive measures and mitigate the health risks caused by SARS-CoV2 (COVID-19). This pandemic has made 2020 an extremely challenging year for the entire world. In Aguascalientes, Mexico, we continued with our usual lives during the first quarter; however, in the last week of March, our university implemented health measures to protect its community, which included confinement, the implementation of distance learning, and the suspension of all academic meetings scheduled for that year. This situation, recognized as the "new normal," spurred the creativity of the university community to adapt planned activities and design emerging projects. In July, the 21st edition of the Research Seminar, convened annually by the General Directorate of Research and Postgraduate Studies with the purpose of disseminating "results of scientific, humanistic, and technological research, as well as strengthening the integration of networks and research groups" (SI, 2020), should have been held. Given that the Seminar could not be held this year, the Department of Research Support generated an emerging project through which it invited professors from all UAA centers, who had completed research projects, to develop a book chapter for a publication that would allow the recognition of the different disciplines from which research is conducted at our university. In the act of bringing together in a single publication the diversity of projects - from Agricultural Sciences, Biomedical Sciences, Design and Construction Sciences, Economic and Administrative Sciences, Natural and Exact Sciences, Social Sciences, Arts, and Humanities - carried out by an academic community that shares the values, mission, vision, and resources - human and material - provided by an institution, an opportunity is recognized to reflect on the notion of system exposed by Mario Bunge, who was one of the Spanish-speaking scientists who has marked a large number of Latin American research.De acuerdo con la declaración del 27 de abril de 2020 de la Organización Mundial de la Salud (OMS), el 31 de diciembre de 2019 se confirmó la presencia de un nuevo coronavirus, causante de múltiples casos de neumonía en la ciudad de Wuhan, China. Por su propagación y gravedad, el 11 de marzo de 2020 la OMS declaró que se había alcanzado el nivel de pandemia (OMS, 2020). En México, el 24 de marzo de 2020, en el Diario Oficial de la Federación (DOF) se publicó un acuerdo para establecer medidas preventivas y mitigar los riesgos de salud provocados por el SARS-CoV2 (covid-19). Esta pandemia ha hecho del 2020 un año sumamente retador para el mundo entero. En Aguascalientes, México, continuamos con la vida habitual durante el primer trimestre; sin embargo, la última semana de marzo nuestra universidad emprendió medidas sanitarias para proteger a su comunidad, entre las que se encontraban el confinamiento, la implementación de cursos a distancia y la suspensión de todos los encuentros académicos programados para ese año. Esta situación, reconocida como “nueva normalidad” impulsó la creatividad de la comunidad universitaria para adecuar las actividades planeadas y para diseñar proyectos emergentes. En el mes de julio debió haberse realizado la emisión 21 del Seminario de Investigación convocado anualmente por la Dirección General de Investigación y Posgrado con el propósito de difundir “resultados de investigaciones científicas, humanísticas y tecnológicas, así como reforzar la integración de redes y grupos de investigación” (SI, 2020). Dado que el Seminario no pudo realizarse este año, el Departamento de Apoyo a la Investigación generó un proyecto emergente mediante el cual convocó a profesores de todos los centros de la UAA, que tuvieran proyectos de investigación concluidos, a elaborar un capítulo de libro para una publicación que permitiera reconocer las distintas disciplinas desde las cuales se realiza investigación en nuestra universidad. En el acto de hacer converger en una misma publicación la diversidad de proyectos –de las Ciencias Agropecuarias, las Ciencias Biomédicas, las Ciencias del Diseño y la Construcción, las Ciencias Económicas y Administrativas, las Ciencias Naturales y Exactas, las Ciencias Sociales, las Artes y las Humanidades–, realizados por una comunidad académica que comparte los valores, misión, visión y recursos –humanos y materiales– dispuestos por una institución, se reconoce una oportunidad para reflexionar sobre la noción de sistema expuesta por Mario Bunge, quien fue uno de los científicos de habla hispana que ha marcado una gran cantidad de investigaciones latinoamericanas

Thoracic liposarcoma: Resection and chest wall reconstruction

Liposarcoma is a malignant neoplasm of mesodermal origin derived from adipose tissue. It most often originates in the extremities and retroperitoneum, and less frequently in the head and neck. Liposarcoma involving the chest wall is extremely rare with few reported cases. Surgery is the mainstay of treatment, and complete resection is the major factor influencing survival. We describe the case of a 65-year-old man diagnosed with a dedifferentiated liposarcoma of the chest wall, who underwent radical resection and chest wall reconstruction with a latissimus dorsi musculocutaneous flap. </jats:p