Genome-wide association study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific heterogeneity

There has been extensive discussion of the Replication Crisis in many fields, including genome-wide association studies

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice

The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats. Three amino acid substitutions distinguish mouse and human Abeta that might contribute to their differing properties in vivo. To examine the amyloidogenic potential of mouse Abeta, we studied several lines of transgenic mice overexpressing wild-type mouse amyloid precursor protein (moAPP) either alone or in conjunction with mutant PS1 (PS1dE9). Neither overexpression of moAPP alone nor co-expression with PS1dE9 caused mice to develop Alzheimer-type amyloid pathology by 24 months of age. We further tested whether mouse Abeta could accelerate the deposition of human Abeta by crossing the moAPP transgenic mice to a bigenic line expressing human APPswe with PS1dE9. The triple transgenic animals (moAPP x APPswe/PS1dE9) produced 20% more Abeta but formed amyloid deposits no faster and to no greater extent than APPswe/PS1dE9 siblings. Instead, the additional mouse Abeta increased the detergent solubility of accumulated amyloid and exacerbated amyloid deposition in the vasculature. These findings suggest that, although mouse Abeta does not influence the rate of amyloid formation, the incorporation of Abeta peptides with differing sequences alters the solubility and localization of the resulting aggregates

A broad look at charcoal rot in the Northern Region broadacre crops through soil sampling and in-crop surveys

Macrophomina phaseolina (Tassi) Goid. is a generalist soil-born pathogen, which is endemic to Australia. The pathogen has a broad host-range of both monocot and dicot plant species which include numerous weed and crop plant species (1, 2). The disease is most commonly identified with summer crops, e.g. soybean, sorghum, sunflower, maize and mungbean (3) and occurs most often when hot, dry conditions occur during the growing season. Current estimates predict that north-eastern Australia will become hotter and dryer as a result of climate change (4, 5). Thus, it is likely that conditions favouring the development of this disease will become more common in the future. However, to date, no work has been done to determine the extent of the pathogen’s presence in Australian soils, in-paddock spatial variability, or the occurrence of the disease as correlated with pathogen presence and population levels. In this paper, we present findings from soil sampling and end-of-season disease assessments in sorghum paddocks across northern New South Wales (NNSW), south eastern Queensland (SEQ) and central Queensland (CQ) during the 2016/17 and 2017/18 summer cropping seasons

A Similarity Measure for GPU Kernel Subgraph Matching

Accelerator architectures specialize in executing SIMD (single instruction, multiple data) in lockstep. Because the majority of CUDA applications are parallelized loops, control flow information can provide an in-depth characterization of a kernel. CUDAflow is a tool that statically separates CUDA binaries into basic block regions and dynamically measures instruction and basic block frequencies. CUDAflow captures this information in a control flow graph (CFG) and performs subgraph matching across various kernel's CFGs to gain insights to an application's resource requirements, based on the shape and traversal of the graph, instruction operations executed and registers allocated, among other information. The utility of CUDAflow is demonstrated with SHOC and Rodinia application case studies on a variety of GPU architectures, revealing novel thread divergence characteristics that facilitates end users, autotuners and compilers in generating high performing code

Chaplygin gas with non-adiabatic pressure perturbations

Perturbations in a Chaplygin gas, characterized by an equation of state $p = -A/\rho$, may acquire non-adiabatic contributions if spatial variations of the parameter $A$ are admitted. This feature is shown to be related to a specific internal structure of the Chaplygin gas. We investigate how perturbations of this type modify the adiabatic sound speed and influence the time dependence of the gravitational potential which gives rise to the Integrated Sachs-Wolfe effect in the anisotropy spectrum of the cosmic microwave background.Comment: 16 pages, comments and references added, accepted for publication in Class.Quantum Gra

Testing the Special Relativity Theory with Neutrino interactions

A recent measurement of neutrino velocity by the OPERA experiment and prediction of energy loss of superluminal neutrino via the pair creation process $\nu\to \nu e^+e^-$ stimulated a search of isolated $e^+e^-$ pairs in detectors with good tracking capability traversed by a large flux of high energy neutrino like NOMAD. NOMAD has already searched for similar topologies. These results can be reinterpreted to provide stringent limits on special relativity violating parameters separately for each $\nu$ species.Comment: 3 pages, 3 figures, 1 table Accepted by EPL (Europhysics Letters