National Accounts ESA. Aggregates 1970-1975. 1976

<p>Model 3 multiple logistic regression analysis for burnout diagnosis.</p

Nutrition lipidique, santé et sport

Intérêt des supplémentations en acides gras polyinsaturés (AGPI) dont les principales classes sont les oméga 3 et 6. Apports conseillés en lipides chez le sportif

Modifications neuro-endocriniennes et métaboliques liées à une situation d'exercices physiques prolongés, chez l'homme influences sur le métabolisme de la leptine et sur le système immunitaire

PARIS5-BU Saints-Pères (751062109) / SudocSudocFranceF

Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects

The purinergic type P1 (adenosine A1 and A2A) receptors and the type P2 (X7) receptor have been suggested to mediate physiological effects of adenosine and adenosine triphosphate on sleep. We aimed to determine gene expression of A1R (receptor), A2AR, and P2RX7 in leukocytes of healthy subjects during total sleep deprivation followed by sleep recovery. Expression of the pro-inflammatory cytokines IL-1β and TNF-α were also determined as they have been characterized as sleep regulatory substances, via P2RX7 activation. Blood sampling was performed on 14 young men (aged 31.9 ± 3.9) at baseline (B), after 24 h of sleep deprivation (24 h-SD), and after one night of sleep recovery (R). We compared gene expression levels after six nights of habitual (22.30–07.00) or extended (21.00–07.00) bedtimes. Using quantitative real-time PCR, the amount of mRNA for A1R, A2AR, P2RX7, TNF-α, and IL-1β was analyzed. After 24 h-SD compared to B, whatever prior sleep condition, a significant increase of A2AR expression was observed that returned to basal level after sleep recovery [day main effect, F(2, 26) = 10.8, p &lt; 0.001]. In both sleep condition, a day main effect on P2RX7 mRNA was observed [F(2, 26) = 6.7, p = 0.005] with significant increases after R compared with 24 h-SD. TNF-α and IL-1β expressions were not significantly altered. Before 24 h-SD (baseline), the A2AR expression was negatively correlated with the latency of stage 3 sleep during the previous night, while that of the A1R positively. This was not observed after sleep recovery following 24 h-SD. This is the first study showing increased A2AR and not A1 gene expression after 24 h-SD in leukocytes of healthy subjects, and this even if bedtime was initially increased by 1.5 h per night for six nights. In conclusion, prolonged wakefulness induced an up-regulation of the A2A receptor gene expression in leukocytes from healthy subjects. Significant correlations between baseline expression of A1 and A2A receptors in peripheral cells and stage 3 sleep suggested their involvement in mediating the effects of adenosine on sleep

Decrease in serum leptin after prolonged physical activity in men.

For effective total quality management (TQM), internal, process-related, as well as external, market-oriented, information is crucial. In particular, external marketing information seems to be very valuable since customers are the ultimate evaluators of the quality of an organization. In this paper, by adopting a services and relationship marketing perspective, we empirically study factors that influence the utilization of quality-related marketing research information by decisionmakers in organizations that strive to monitor and improve their quality levels. Our results show clearly that the use of quality-related information is most strongly influenced by the quality of informational contents. In addition, satisfaction with a specific quality-related research project functions as an important mediator between service quality of the project on the one hand and decision-maker trust in the provider and information use on the other hand. The results can be especially useful to marketing research agencies that strive to improve the quality of the service they deliver to organizations actively involved in the area of TQM

Effets d'un entraînement en endurance sur des patients atteints de la maladie de McArdle

Effets d'un entraînement modéré de type aérobie (8 semaines, 3 séances de 45 minutes/semaine à 60-70 % de la fréquence cardiaque maximale) sur la réponse à l'exercice chez des patients atteints d'une déficience en myophosphorylase