Metastable SUSY Breaking, de Sitter Moduli Stabilisation and K\"ahler Moduli Inflation

We study the influence of anomalous U(1) symmetries and their associated D-terms on the vacuum structure of global field theories once they are coupled to N=1 supergravity and in the context of string compactifications with moduli stabilisation. In particular, we focus on a IIB string motivated construction of the ISS scenario and examine the influence of one additional U(1) symmetry on the vacuum structure. We point out that in the simplest one-Kahler modulus compactification, the original ISS vacuum gets generically destabilised by a runaway behaviour of the potential in the modulus direction. In more general compactifications with several Kahler moduli, we find a novel realisation of the LARGE volume scenario with D-term uplifting to de Sitter space and both D-term and F-term supersymmetry breaking. The structure of soft supersymmetry breaking terms is determined in the preferred scenario where the standard model cycle is not stabilised non-perturbatively and found to be flavour universal. Our scenario also provides a purely supersymmetric realisation of Kahler moduli (blow-up and fibre) inflation, with similar observational properties as the original proposals but without the need to include an extra (non-SUSY) uplifting term.Comment: 38 pages, 8 figures. v2: references added, minor correction

Moduli stabilization with Fayet-Iliopoulos uplift

In the recent years, phenomenological models of moduli stabilization were proposed, where the dynamics of the stabilization is essentially supersymmetric, whereas an O'Rafearthaigh supersymmetry breaking sector is responsible for the "uplift" of the cosmological constant to zero. We investigate the case where the uplift is provided by a Fayet-Iliopoulos sector. We find that in this case the modulus contribution to supersymmetry breaking is larger than in the previous models. A first consequence of this class of constructions is for gauginos, which are heavier compared to previous models. In some of our explicit examples, due to a non-standard gauge-mediation type negative contribution to scalars masses, the whole superpartner spectrum can be efficiently compressed at low-energy. This provides an original phenomenology testable at the LHC, in particular sleptons are generically heavier than the squarks.Comment: 29 pages, 2 figure

Does distance matter in explaining international expansion? Evidence from the global mobile telecommunications industry [¿Cómo afecta la distancia a la expansión internacional de las empresas? Evidencia en la industria de las telecomunicaciones móviles]

The aim of this study is to analyse how the distance between countries determines host country selection. To explain foreign market entry we use two dimensions of the distance between countries: (1) geographic distance and (2) historical ties between the home and the host countries. We carry out descriptive, empirical and case study analyses in the mobile telecommunications industry to study how these two dimensions of distance determine the entrance of firms in foreign countries. Our work shows that geographic distance negatively affects the entrance of firms in host countries while historical ties between countries encourage firms to enter the host country. Moreover, historical ties positively moderate the relationship between geographic distance and market entry. El objetivo de este trabajo es estudiar el efecto que la distancia entre los países tiene sobre la selección del país de destino. En particular, hacemos uso de dos dimensiones de la distancia entre el país de origen y el de destino para explicar la entrada: (1) la dimensión geográfica y (2) la existencia de lazos históricos. Tomando como referencia la industria de las telecomunicaciones móviles, ofrecemos una aproximación en tres etapas a través de un estudio descriptivo en profundidad, un análisis empírico y una presentación de tres casos paradigmáticos en el sector. Nuestros resultados muestran que las empresas son más propensas a entrar en países que presentan una menor distancia geográfica o histórica. Además, concluimos que los lazos históricos moderan positivamente la relación entre la distancia geográfica y la entrada

Evolution of durability and mechanical properties of ordinary portland cement concretes in sulphates attack

Concrete in sulphates environments often undergoes significant alterations that often have significant adverse results on its engineering properties. However, the choice of cement type is a very important factor for concrete exposed in aggressive environment. This research presents the effect of two types of cement on the mechanical and microstructure properties of ordinary concretes exposed in aggressive solution dosed with 5% of gypsum (Ca2SO4.2H2O). The tests studied in this experimental part were the compressive strength, flexural strength, thermogravimetry, mercury intrusion porosimetry and mass variations of the concrete. The results clearly show that the CEM I 42.5 is suitable for the formulation of concretes exposed to sulphate attack and their properties are better compared with the CEM II/A 42.5

Structural Brain Network Reorganization and Social Cognition Related to Adverse Perinatal Condition from Infancy to Early Adolescence.

Adverse conditions during fetal life have been associated to both structural and functional changes in neurodevelopment from the neonatal period to adolescence. In this study, connectomics was used to assess the evolution of brain networks from infancy to early adolescence. Brain network reorganization over time in subjects who had suffered adverse perinatal conditions is characterized and related to neurodevelopment and cognition. Three cohorts of prematurely born infants and children (between 28 and 35 weeks of gestational age), including individuals with a birth weight appropriated for gestational age and with intrauterine growth restriction (IUGR), were evaluated at 1, 6, and 10 years of age, respectively. A common developmental trajectory of brain networks was identified in both control and IUGR groups: network efficiencies of the fractional anisotropy (FA)-weighted and normalized connectomes increase with age, which can be related to maturation and myelination of fiber connections while the number of connections decreases, which can be associated to an axonal pruning process and reorganization. Comparing subjects with or without IUGR, a similar pattern of network differences between groups was observed in the three developmental stages, mainly characterized by IUGR group having reduced brain network efficiencies in binary and FA-weighted connectomes and increased efficiencies in the connectome normalized by its total connection strength (FA). Associations between brain networks and neurobehavioral impairments were also evaluated showing a relationship between different network metrics and specific social cognition-related scores, as well as a higher risk of inattention/hyperactivity and/or executive functional disorders in IUGR children

Microbial engineering of new streptomyces sp. from extreme environments for novel antibiotics and anticancer drugs

Today there is a tremendous need for new antibiotics and novel cytotoxic compounds against cancer cells to develop efficient alternative treatment to chemotherapy. We have searched for highly active Streptomyces strains in the driest desert in the world, the Atacama desert in northern Chile. We have identified several new strains and found many novel antibiotics and anticancer agents (“Chaxamycins”, “Chaxalactins” and “Atacamycins”) from Streptomyces C34 and C38. A genome scale model of the metabolism of Streptomyces leeuwenhoekii C34 has been developed from its genome sequence. The model, iVR1007, has 1726 reactions including 239 for transport, reactions for secondary metabolite biosynthesis, 1463 metabolites and 1007 genes. The model was validated with experimental data of growth in 89, 54 and 23 sole carbon, nitrogen and phosphorous sources, respectively, and showed a high level of accuracy (82.5 %). We have included reactions for desferrioxamines, ectoine, Chaxamycins, Chaxalactins and for the hybrid polyketides/non-ribosomal peptide synthesized by the halogenase cluster. A detailed Metabolic Flux Balance Analysis was carried out in order to study the metabolic pathways of Chaxalactins, Chaxamycins and the product of the halogenase cluster, by recognizing overexpression targets and useful knock-out sites to increase production of these secondary metabolites. Alternatively we have identified the gene cluster in S. leeuwenhoekii C34 responsible for the biosynthesis of the Chaxamycins and Chaxalactins and have cloned the whole gene cluster in a much more efficient strain of Streptomyces, namely S. coelicolor A3 whose heterologous expression of gene clusters from other Streptomyces strains has been successfully tested. Our recent results concerning these two alternative strategies for identification and overproduction of these important secondary metabolites will be presented and discussed in this presentation

On supersymmetric Minkowski vacua in IIB orientifolds

Supersymmetric Minkowski vacua in IIB orientifold compactifications based on orbifolds with background fluxes and non-perturbative superpotentials are investigated. Especially, microscopic requirements and difficulties to obtain such vacua are discussed. We show that orbifold models with one and two complex structure moduli and supersymmetric 2-form flux can be successfully stabilized to such vacua. By taking additional gaugino condensation on fixed space-time filling D3-branes into account also models without complex structure can be consistently stabilized to Minkowski vacua.Comment: 17 pages, 2 figures; More detailed proof for absence of complex flat directions in susy AdS vacua given; Footnotes and reference adde

Metastable supergravity vacua with F and D supersymmetry breaking

We study the conditions under which a generic supergravity model involving chiral and vector multiplets can admit viable metastable vacua with spontaneously broken supersymmetry and realistic cosmological constant. To do so, we impose that on the vacuum the scalar potential and all its first derivatives vanish, and derive a necessary condition for the matrix of its second derivatives to be positive definite. We study then the constraints set by the combination of the flatness condition needed for the tuning of the cosmological constant and the stability condition that is necessary to avoid unstable modes. We find that the existence of such a viable vacuum implies a condition involving the curvature tensor for the scalar geometry and the charge and mass matrices for the vector fields. Moreover, for given curvature, charges and masses satisfying this constraint, the vector of F and D auxiliary fields defining the Goldstino direction is constrained to lie within a certain domain. The effect of vector multiplets relative to chiral multiplets is maximal when the masses of the vector fields are comparable to the gravitino mass. When the masses are instead much larger or much smaller than the gravitino mass, the effect becomes small and translates into a correction to the effective curvature. We finally apply our results to some simple classes of examples, to illustrate their relevance.Comment: 40 pages; v2 some clarifications added in the introduction; v3 some typos correcte

An Effective Description of the Landscape - II

We continue our analysis of establishing the reliability of "simple" effective theories where massive fields are "frozen" rather than integrated out, in a wide class of four dimensional theories with global or local N=1 supersymmetry. We extend our previous work by adding gauge fields and O(1) Yukawa-like terms for the charged fields in the superpotential. For generic Kaehler potentials, a meaningful freezing is allowed for chiral multiplets only, whereas in general heavy vector fields have to properly be integrated out. Heavy chiral fields can be frozen if they approximately sit to supersymmetric solutions along their directions and, in supergravity, if the superpotential at the minimum is small, so that a mass hierarchy between heavy and light fields is ensured. When the above conditions are met, we show that the simple effective theory is generally a reliable truncation of the full one.Comment: 20 page