Addressing the Needs of the Saint Clair Attendance Policies

The Saint Clair School is a small rural school that houses kindergarten through twelfth grade in one school building. Currently the school has two attendance policies, one for elementary school and one for the high school. The two polices are very different in how they define attendance and choose to discipline absences. The purpose of this Capstone Project is to make recommendations to the Saint Clair School on how to make changes to their current attendance policies so that there are solid expectations from the students regarding absences. Research Question: What components make an effective attendance policy in a school that houses kindergarten through twelfth grade in one school building

Compassion Fatigue and Compassion Satisfaction among Professionals Working With Survivors of Sex Trafficking

No abstract provided

Compassion Fatigue and Compassion Satisfaction among Professionals Working With Survivors of Sex Trafficking

No abstract provided

Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia

Treatment options for acute myeloid leukemia (AML) remain extremely limited and associated with significant toxicity. Nicotinamide phosphoribosyltransferase (NAMPT) is involved in the generation of NAD+ and a potential therapeutic target in AML. We evaluated the effect of KPT-9274, a p21-activated kinase 4/NAMPT inhibitor that possesses a unique NAMPT-binding profile based on in silico modeling compared with earlier compounds pursued against this target. KPT-9274 elicited loss of mitochondrial respiration and glycolysis and induced apoptosis in AML subtypes independent of mutations and genomic abnormalities. These actions occurred mainly through the depletion of NAD+, whereas genetic knockdown of p21-activated kinase 4 did not induce cytotoxicity in AML cell lines or influence the cytotoxic effect of KPT-9274. KPT-9274 exposure reduced colony formation, increased blast differentiation, and diminished the frequency of leukemia-initiating cells from primary AML samples; KPT-9274 was minimally cytotoxic toward normal hematopoietic or immune cells. In addition, KPT-9274 improved overall survival in vivo in 2 different mouse models of AML and reduced tumor development in a patient-derived xenograft model of AML. Overall, KPT-9274 exhibited broad preclinical activity across a variety of AML subtypes and warrants further investigation as a potential therapeutic agent for AML

Additional file 1 of The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling

Supplementary Material