Bereavement and marriage are associated with antibody response to influenza vaccination in the elderly

Stressful life events exposure including bereavement, an event commonly experienced by elderly people, social support, marital status and satisfaction were examined in relation to antibody response to the annual trivalent influenza vaccination in an elderly community sample (N = 184). Antibody response was assessed at baseline, and at one and 12 months following vaccination. Taking into account baseline antibody titer, overall life events exposure and social support were not associated with response to any of the influenza strains. However, bereavement in the year prior to vaccination was negatively associated with the one-month response to the A/Panama and B/Shangdong strains. Being married and having higher marital satisfaction was also associated with higher peak responses to the A/Panama influenza strain at one month. The positive association between marital satisfaction and A/Panama response was particularly evident in the younger half of the married sample. These associations largely withstood adjustment for potential confounders. Thus, in the elderly, peak antibody response was associated with bereavement and marriage, and not the more general factors, life events and social support, related to antibody response in student samples. This suggests the importance of taking a life course approach to examining relationships between psychosocial factors and immunity, and that interventions to modify the impact of these factors should address those most salient for each age group

Creating Family: A Phenomenological Needs-Assessment of Adoptive Parents for Implications in Dance/Movement Therapy

The purpose of this study was to identify adoptive parents’ predominant, post-adoption needs through a phenomenological needs-assessment. While the initial lens of attachment theory was utilized, the phenomenological methodology allowed for a variety of needs and experiences to emerge. The results served as a basis for exploring how dance/movement therapy (DMT) may effectively play a role in adoption services. The participants of the study included five adoptive parents and two adoption counselors. The data were collected through semi-structured, in-depth interviews and analyzed using Anderson’s intuitive inquiry, including a resonance panel of individuals who had experience with adoption, personally or professionally. Findings suggested that mother/child bonding was a central focus for the participants, and that secure attachments were attained without outside intervention. The creation of these secure attachments, despite some challenges and the absence of biological processes, reflected the resilience of the families and the power of parent child connection. Other needs came forward because of the foundation of these secure attachments. These needs included validation of parenting abilities, addressing child’s identity concerns, finding community support, integrating adopted children into family units, maintaining maternal health, and calming the child at different developmental stages. Implications are explored, suggesting that DMT may play an effective role in adoption support in various ways. These include allowing space and techniques for focusing on parent-child connection, facilitating identity exploration, and increasing connection between biological and adopted family members, among others. This study suggests that further research, including program development, is warranted to explore the variety of ways DMT can support adoptive families

Origin of the Second-Order Proton Catalysis of Ferriin Reduction in Belousov-Zhabotinsky Reactions: Density Functional Studies of Ferroin and Ferriin Aggregates with Outer Sphere Ligands Sulfate, Bisulfate, and Sulfuric Acid

The detailed mechanisms of Belousov-Zhabotinsky oscillating reactions continue to present grand challenges, even after half a century of study. The origin of the pH dependence of the oscillation pattern had never been rigorously identified. In our recent kinetic study of one of the key Belousov-Zhabotinsky reactions, the iron-catalyzed bromate oxidation of malonic acid, compelling agreement between experiments and kinetic simulations was achieved only with the inclusion of second-order proton catalysis of the reduction of the [Fe(phen)3]3+ species. After exhausting all other avenues in search of an explanation of this proton catalysis, we considered the possibility that the parent iron-phenanthroline complexes could aggregate with neutral and anionic outer sphere ligands (OSLs) in the highly concentrated sulfuric acid solution, and we hypothesized that OSL protonation would increase the capacity of the aggregated complex to oxidize the organic fuel. We performed potential energy surface analyses at the SMD(APFD/6-311G*) level of complexes of the types [Fe(phen)3(SO42-)m(HSO4-)n(H2SO4)o](c-2m-n)+ for ferriin (c = 3) and ferroin (c = 2) aggregated with m sulfate, n bisulfate, and o sulfuric acid OSLs. We present structures of the OSL aggregates, develop a nomenclature for their description, and characterize their electronic structure. The structural chemistry provides the foundation to discuss the ferroin/ferriin redox couple with emphasis on the relationship between the vertical electron affinities of ferriin aggregates and their OSL protonation states. For proton catalysis to manifest itself, double-protonation paths that are slightly endergonic should be present, and proton affinities of aggregated OSLs allow the identification of such double-protonation chains. As a first test of our mechanistic proposal for the second-order proton catalysis of the Belousov-Zhabotinsky reaction, the results presented here provide compelling evidence in support of the importance of outer sphere ligation of the iron catalyst

Broadband Relaxation-Optimized Polarization Transfer in Magnetic Resonance

Many applications of magnetic resonance are limited by rapid loss of spin coherence caused by large transverse relaxation rates. In nuclear magnetic resonance (NMR) of large proteins, increased relaxation losses lead to poor sensitivity of experiments and increased measurement time. In this paper we develop broadband relaxation optimized pulse sequences (BB-CROP) which approach fundamental limits of coherence transfer efficiency in the presence of very general relaxation mechanisms that include cross-correlated relaxation. These broadband transfer schemes use new techniques of chemical shift refocusing (STAR echoes) that are tailored to specific trajectories of coupled spin evolution. We present simulations and experimental data indicating significant enhancement in the sensitivity of multi-dimensional NMR experiments of large molecules by use of these methods

Being Healthy: a Grounded Theory Study of Help Seeking Behaviour among Chinese Elders living in the UK

The health of older people is a priority in many countries as the world’s population ages. Attitudes towards help seeking behaviours in older people remain a largely unexplored field of research. This is particularly true for older minority groups where the place that they have migrated to presents both cultural and structural challenges. The UK, like other countries,has an increasingly aging Chinese population about who relatively little is known. This study used a qualitative grounded theory design following the approach of Glaser (1978). Qualitative data were collected using semi-structured interviews with 33 Chinese elders who were aged between 60 and 84, using purposive and theoretical sampling approaches. Data were analysed using the constant comparative method until data saturation occurred and a substantive theory was generated. ‘Being healthy’ (the core category) with four interrelated categories: self-management, normalizing/minimizing, access to health services, and being cured form the theory. The theory was generated around the core explanations provided by participants and Chinese elders’ concerns about health issues they face in their daily life. We also present data about how they direct their health-related activities towards meeting their physical and psychological goals of being healthy. Their differential understanding of diseases and a lack of information about health services were potent predictors of non�help seeking and ‘self’ rather than medical management of their illnesses. This study highlights the need for intervention and health support for Chinese elders

Static and Dynamic Phases for Vortex Matter with Attractive Interactions

Exotic vortex states with long range attraction and short range repulsion have recently been proposed to arise in superconducting hybrid structures and multi-band superconductors. Using large scale simulations we examine the static and dynamic properties of such vortex states interacting with random and periodic pinning. In the absence of pinning this system does not form patterns but instead completely phase separates. When pinning is present there is a transition from inhomogeneous to homogeneous vortex configurations similar to a wetting phenomenon. Under an applied drive, a dynamical dewetting process can occur from a strongly pinned homogeneous state into pattern forming states. We show that a signature of the exotic vortex interactions under transport measurements is a robust double peak feature in the differential conductivity curves.Comment: 5 pages, 4 postscript figure