Analisi sperimentale per lo studio del comportamento idromeccanico di un terreno costipato

La valutazione delle condizioni di stabilità delle opere in terra rappresenta una difficoltà spesso sottovalutata nella pratica ingegneristica e, viceversa, di attualità della ricerca scientifica in geotecnica. Infatti, è certamente vero che il contenuto d’acqua dei terreni costituenti tali opere e la distribuzione della pressione interstiziale nelle strutture in terra variano nel tempo a causa dei mutevoli effetti delle condizioni idrometriche e climatiche al contorno, cosa che influenza significativamente le condizioni di stabilità dell’opera. In questo lavoro è presentata una procedura per la caratterizzazione del comportamento idromeccanico di una miscela di sabbia e limo al variare dell’energia di costipamento. I dati sperimentali vengono discussi al fine di contribuire allo studio del comportamento in esercizio delle opere in terra

Analisi predittive del comportamento idro-meccanico di un modello di argine fluviale in condizioni di flusso transitorio

Il frequente manifestarsi di eventi alluvionali per collasso di opere in terra costituisce un problema di particolare rilevanza nella valutazione del rischio idrogeologico e della pianificazione territoriale. In questo contesto risulta cruciale un’accurata stima delle condizioni di stabilità che tenga conto dello stato di parziale saturazione dei terreni costituenti il rilevato. Altrettanto importante è tenere conto delle condizioni di flusso transitorio che si instaurano negli argini e nei terreni di fondazione a seguito delle continue variazioni del livello idrometrico dei corsi d’acqua. Tutto ciò influenza notevolmente la risposta idro-meccanica delle opere in parola. In tale prospettiva la nota illustra uno studio numerico, basato sull’approccio agli elementi finiti e sul metodo dell’Equilibrio Limite, per l’analisi del comportamento di un argine fluviale rappresentativo delle opere di difesa idraulica degli affluenti alpini e appenninici del fiume Po. Lo studio proposto tiene debito conto delle condizioni di parziale saturazione del corpo arginale interessato da un moto di filtrazione in regime transitorio. Le analisi numeriche proposte costituiscono parte integrante della progettazione di una prova in centrifuga geotecnica su un modello fisico in scala ridotta, finalizzata a investigare la vulnerabilità delle infrastrutture arginali nei confronti di eventi di piena

Modellazione fisica in centrifuga di un argine fluviale soggetto a forzanti idrauliche

In questo lavoro sono riportati i risultati sperimentali di una prova in centrifuga su un modello di argine fluviale soggetto ad una progressiva sollecitazione idraulica. Le misure di pressioni neutre e di suzione nell’argine mostrano che il fronte di saturazione raggiunge il lato campagna attingendo la condizione stazionaria solo dopo una persistenza irrealistica dell'evento di piena simulato. Pertanto svolgere la progettazione o la valutazione delle condizioni di sicurezza di un argine fluviale con proprietà simili a quello testato nel presente lavoro, assumendo l'ipotesi semplificata di un regime stazionario di filtrazione potrebbe risultare in molti casi un approccio eccessivamente conservativo e, comunque, poco significativo

SWELTO - Space WEather Laboratory in Turin Observatory

SWELTO - Space WEather Laboratory in Turin Observatory is a conceptual framework where new ideas for the analysis of space-based and ground-based data are developed and tested. The input data are (but not limited to) remote sensing observations (EUV images of the solar disk, Visible Light coronagraphic images, radio dynamic spectra, etc...), in situ plasma measurements (interplanetary plasma density, velocity, magnetic field, etc...), as well as measurements acquired by local sensors and detectors (radio antenna, fluxgate magnetometer, full-sky cameras, located in OATo). The output products are automatic identification, tracking, and monitoring of solar stationary and dynamic features near the Sun (coronal holes, active regions, coronal mass ejections, etc...), and in the interplanetary medium (shocks, plasmoids, corotating interaction regions, etc...), as well as reconstructions of the interplanetary medium where solar disturbances may propagate from the Sun to the Earth and beyond. These are based both on empirical models and numerical MHD simulations. The aim of SWELTO is not only to test new data analysis methods for future application for Space Weather monitoring and prediction purposes, but also to procure, test and deploy new ground-based instrumentation to monitor the ionospheric and geomagnetic responses to solar activity. Moreover, people involved in SWELTO are active in outreach to disseminate the topics related with Space Weather to students and the general public

Guía de buenas prácticas para establecimientos lecheros : material de referencia de la Red de BPA

Con el objetivo de concentrar varios esfuerzos aislados que se han llevado a cabo en el país, INTA, la Fac. Cs. Agropecuarias de la UNC y APROCAL han tenido la iniciativa de convocar a especialistas y representantes del sector lechero nacional para trabajar en el desarrollo de una guía de buenas prácticas en el tambo consensuada entre los diferentes representantes del sector lechero. Esta guía procura ser una propuesta de fácil interpretación para ser consultada permanentemente por parte de quienes trabajan y conducen los establecimientos lecheros para apoyarse en aspectos que hacen al aseguramiento de la calidad en el tambo. A través de esta se pretende brindar recomendaciones de Buenas Prácticas para maximizar la producción y la calidad de leche en sistemas productivos sustentables.EEA PergaminoFIL: Negri Rodriguez, Livia María. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Tecnología de Alimentos; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Aimar, María Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Costamagna, Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Callieri, Carlos. DeLaval Productor de Maquinaria Lechera y Agrícola; Argentina. Asociación PRO Calidad de la Leche y sus Derivados (PROCAL); ArgentinaFil: Herrero, María Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Charlón, Verónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Leiva, Antonio. Sancor; ArgentinaFil: Tentor, Gonzalo. Buenas Prácticas Agropecuarias (BPA); ArgentinaFil: Raciti, Julio. Manfrey Informatica; ArgentinaFil: Rampone, Alberto. Universidad Nacional de Villa María; ArgentinaFil: Chavez, Javier. Lactodiagnóstico Sur; ArgentinaFil: Gaggiotti, Mónica del Carmen. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Boffa, Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Paraná. Agencia de Extensión Rural La Paz. Oficina Técnica Hernandarias; ArgentinaFil: Mancuso, Walter. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Praraná; ArgentinaFil: Pautasso, Néstor. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Praraná; ArgentinaFil: Walter, Emilio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Moltoni, Luciana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación Ingeniería Rural; ArgentinaFil: Serrano, Pedro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Pergamino. Agencia de Extensión Rural Coronel Brandsen; ArgentinaFil: Abdala, Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Gonzalez Pereyra, Ana Valeria. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Lactodiagnóstico Sur; ArgentinaFil: Sardi, Graciela. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Gigli, Isabel. Universidad Nacional de La Pampa; ArgentinaFil: Rodríguez, Julián. La Lacteo; ArgentinaFil: García, Karina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Brunas, Lucas. García Hermanos; ArgentinaFil: Bontá, Marcos. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Lactodiagnóstico Sur; Argentin

Beta-Blocker Use in Older Hospitalized Patients Affected by Heart Failure and Chronic Obstructive Pulmonary Disease: An Italian Survey From the REPOSI Register

Beta (β)-blockers (BB) are useful in reducing morbidity and mortality in patients with heart failure (HF) and concomitant chronic obstructive pulmonary disease (COPD). Nevertheless, the use of BBs could induce bronchoconstriction due to β2-blockade. For this reason, both the ESC and GOLD guidelines strongly suggest the use of selective β1-BB in patients with HF and COPD. However, low adherence to guidelines was observed in multiple clinical settings. The aim of the study was to investigate the BBs use in older patients affected by HF and COPD, recorded in the REPOSI register. Of 942 patients affected by HF, 47.1% were treated with BBs. The use of BBs was significantly lower in patients with HF and COPD than in patients affected by HF alone, both at admission and at discharge (admission, 36.9% vs. 51.3%; discharge, 38.0% vs. 51.7%). In addition, no further BB users were found at discharge. The probability to being treated with a BB was significantly lower in patients with HF also affected by COPD (adj. OR, 95% CI: 0.50, 0.37-0.67), while the diagnosis of COPD was not associated with the choice of selective β1-BB (adj. OR, 95% CI: 1.33, 0.76-2.34). Despite clear recommendations by clinical guidelines, a significant underuse of BBs was also observed after hospital discharge. In COPD affected patients, physicians unreasonably reject BBs use, rather than choosing a β1-BB. The expected improvement of the BB prescriptions after hospitalization was not observed. A multidisciplinary approach among hospital physicians, general practitioners, and pharmacologists should be carried out for better drug management and adherence to guideline recommendations

Prescription appropriateness of anti-diabetes drugs in elderly patients hospitalized in a clinical setting: evidence from the REPOSI Register

Diabetes is an increasing global health burden with the highest prevalence (24.0%) observed in elderly people. Older diabetic adults have a greater risk of hospitalization and several geriatric syndromes than older nondiabetic adults. For these conditions, special care is required in prescribing therapies including anti- diabetes drugs. Aim of this study was to evaluate the appropriateness and the adherence to safety recommendations in the prescriptions of glucose-lowering drugs in hospitalized elderly patients with diabetes. Data for this cross-sectional study were obtained from the REgistro POliterapie-Società Italiana Medicina Interna (REPOSI) that collected clinical information on patients aged ≥ 65 years acutely admitted to Italian internal medicine and geriatric non-intensive care units (ICU) from 2010 up to 2019. Prescription appropriateness was assessed according to the 2019 AGS Beers Criteria and anti-diabetes drug data sheets.Among 5349 patients, 1624 (30.3%) had diagnosis of type 2 diabetes. At admission, 37.7% of diabetic patients received treatment with metformin, 37.3% insulin therapy, 16.4% sulfonylureas, and 11.4% glinides. Surprisingly, only 3.1% of diabetic patients were treated with new classes of anti- diabetes drugs. According to prescription criteria, at admission 15.4% of patients treated with metformin and 2.6% with sulfonylureas received inappropriately these treatments. At discharge, the inappropriateness of metformin therapy decreased (10.2%, P < 0.0001). According to Beers criteria, the inappropriate prescriptions of sulfonylureas raised to 29% both at admission and at discharge. This study shows a poor adherence to current guidelines on diabetes management in hospitalized elderly people with a high prevalence of inappropriate use of sulfonylureas according to the Beers criteria

The “Diabetes Comorbidome”: A Different Way for Health Professionals to Approach the Comorbidity Burden of Diabetes

(1) Background: The disease burden related to diabetes is increasing greatly, particularly in older subjects. A more comprehensive approach towards the assessment and management of diabetes’ comorbidities is necessary. The aim of this study was to implement our previous data identifying and representing the prevalence of the comorbidities, their association with mortality, and the strength of their relationship in hospitalized elderly patients with diabetes, developing, at the same time, a new graphic representation model of the comorbidome called “Diabetes Comorbidome”. (2) Methods: Data were collected from the RePoSi register. Comorbidities, socio-demographic data, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), and functional status (Barthel Index), were recorded. Mortality rates were assessed in hospital and 3 and 12 months after discharge. (3) Results: Of the 4714 hospitalized elderly patients, 1378 had diabetes. The comorbidities distribution showed that arterial hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and COPD (22.7%), were the more frequent in subjects with diabetes. The graphic comorbidome showed that the strongest predictors of death at in hospital and at the 3-month follow-up were dementia and cancer. At the 1-year follow-up, cancer was the first comorbidity independently associated with mortality. (4) Conclusions: The “Diabetes Comorbidome” represents the perfect instrument for determining the prevalence of comorbidities and the strength of their relationship with risk of death, as well as the need for an effective treatment for improving clinical outcomes

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population