The Multiplicity Polar Theorem, collections of 1-forms and Chern numbers

In this work we show how the Multiplicity Polar Theorem can be used to calculate Chern numbers for a collection of 1-forms.Comment: 27 page

Drug-induced dermatomyositis after lacosamide: A case report.

Here we describe a caseof a woman who had DM after treatment withlacosamide. To our knowledge, drug-induced DMfrom lacosamide has not been reported previously

PIA : more accurate taxonomic assignment of metagenomic data demonstrated on sedaDNA from the North sea

Assigning metagenomic reads to taxa presents significant challenges. Existing approaches address some issues, but are mostly limited to metabarcoding or optimized for microbial data. We present PIA (Phylogenetic Intersection Analysis): a taxonomic binner that works from standard BLAST output while mitigating key effects of incomplete databases. Benchmarking against MEGAN using sedaDNA suggests that, while PIA is less sensitive, it can be more accurate. We use known sequences to estimate the accuracy of PIA at up to 96% when the real organism is not represented in the database. For ancient DNA, where taxa of interest are frequently over-represented domesticates or absent, poorly-known organisms, more accurate assignment is critical, even at the expense of sensitivity. PIA offers an approach to objectively filter out false positive hits without the need to manually remove taxa and so make presuppositions about past environments and their palaeoecologies

Modelling biological invasions: individual to population scales at interfaces

Extracting the population level behaviour of biological systems from that of the individual is critical in understanding dynamics across multiple scales and thus has been the subject of numerous investigations. Here, the influence of spatial heterogeneity in such contexts is explored for interfaces with a separation of the length scales characterising the individual and the interface, a situation that can arise in applications involving cellular modelling. As an illustrative example, we consider cell movement between white and grey matter in the brain which may be relevant in considering the invasive dynamics of glioma. We show that while one can safely neglect intrinsic noise, at least when considering glioma cell invasion, profound differences in population behaviours emerge in the presence of interfaces with only subtle alterations in the dynamics at the individual level. Transport driven by local cell sensing generates predictions of cell accumulations along interfaces where cell motility changes. This behaviour is not predicted with the commonly used Fickian diffusion transport model, but can be extracted from preliminary observations of specific cell lines in recent, novel, cryo-imaging. Consequently, these findings suggest a need to consider the impact of individual behaviour, spatial heterogeneity and especially interfaces in experimental and modelling frameworks of cellular dynamics, for instance in the characterisation of glioma cell motility

Energy dependence of ratios of multiplicities and their slopes for gluon and quark jets

The difference between the ratio of multiplicities and the ratio of their derivatives on energy for gluon and quark jets is calculated up to next-to-next-to leading order of perturbative QCD. Its non-zero value is uniquely defined by the running property of the QCD coupling constant. It is shown that this difference is rather small compared to values which can be obtained from experimental data. This disagreement can be ascribed either to strong non-perturbative terms or to experimental problems with a scale choice, jets separation and inadequate assignement of soft particles to jets.Comment: 5 pages, LATEX, no Figs; submitted to JETP Let

A performance evaluation of commercial fibrinogen reference preparations and assays for Clauss and PT-derived fibrinogen

The wide availability of fibrinogen estimations based on the prothrombin time (PT-Fg) has caused concern about the variability and clinical utility of fibrinogen assays. In a multi-centre study, we investigated fibrinogen assays using various reagents and analysers, Clauss assays generally gave good agreement, although one reagent gave 15-30% higher values in DIC and thrombolysis. Two commercial reference preparations had much lower potencies than the manufacturers declared, and plasma turbidity influenced parallelism in some Clauss assays, PT-Fg assays gave higher values than Clauss and showed calibrant dependent effects, the degree of disparity correlating with calibrant and test sample turbidity. Analyser and thromboplastin dependent differences were noted. The relationship between Clauss and PT-Fg assays was sigmoid, and the plateau of maximal PT-Fg differed by about 2 g/l between reagents. ELISA and immunonephelometric assays correlated well, but with a high degree of scatter. Antigen levels were higher than Clauss, but slightly lower than PT-Fg assays, which appeared to be influenced by degraded fibrinogen. Clauss assays are generally reproducible between centres, analysers and reagents, but PT-Fg assays are not reliable in clinical settings

Annual Lipid Cycles in the Lizard Cnemidophorus Tigris

Annual lipid cycles were determined for adult male and female Cnemidophorus tigris collected near El Paso, Texas during 1970-1971

Sobolev Inequalities for Differential Forms and Lq,pL_{q,p}-cohomology

We study the relation between Sobolev inequalities for differential forms on a Riemannian manifold $(M,g)$ and the $L_{q,p}$-cohomology of that manifold. The $L_{q,p}$-cohomology of $(M,g)$ is defined to be the quotient of the space of closed differential forms in $L^p(M)$ modulo the exact forms which are exterior differentials of forms in $L^q(M)$.Comment: This paper has appeared in the Journal of Geometric Analysis, (only minor changes have been made since verion 1

Development of magnetostrictive active members for control of space structures

The goal of this Phase 2 Small Business Innovative Research (SBIR) project was to determine the technical feasibility of developing magnetostrictive active members for use as truss elements in space structures. Active members control elastic vibrations of truss-based space structures and integrate the functions of truss structure element, actively controlled actuator, and sensor. The active members must control structural motion to the sub-micron level and, for many proposed space applications, work at cryogenic temperatures. Under this program both room temperature and cryogenic temperature magnetostrictive active members were designed, fabricated, and tested. The results of these performance tests indicated that room temperature magnetostrictive actuators feature higher strain, stiffness, and force capability with lower amplifier requirements than similarly sized piezoelectric or electrostrictive active members, at the cost of higher mass. Two different cryogenic temperature magnetostrictive materials were tested at liquid nitrogen temperatures, both with larger strain capability than the room temperature magnetostrictive materials. The cryogenic active member development included the design and fabrication of a cryostat that allows operation of the cryogenic active member in a space structure testbed

Cityscapes without figures: geophysics, computing and the future of urban studies

Ye