Extensão universitária: retrospecto histórico do período 1951-2018 na Universidade de Sorocaba / University extension: historical retrospective of the period 1951-2018 at the University of Sorocaba

 O presente artigo apresenta os principais acontecimentos e datas da história da Universidade de Sorocaba, no período de 1951 a 2018, relacionando-os ao processo de desenvolvimento e de amadurecimento das propostas extensionistas da Universidade de Sorocaba. Acompanhando o crescimento físico da instituição, a ampliação e a criação de novos câmpus, as atividades de extensão foram  também aumentando, principalmente com o oferecimento de cursos, realização de eventos, palestras e  ofertas de bolsas de estudo visando fortalecer e ampliar o diálogo entre os saberes universitários e os conhecimentos e práticas das comunidades locais. Os resultados mostram uma melhora quantitativa e qualitativa nas relações entre universidade e comunidade, assim como um amadurecimento da  Uniso, nesse período, sobre seu próprio entendimento do conceito de  Extensão Universitária e seus papeissocial, político e educacional nos dias de hoje

Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency

Adenosine deaminase (ADA) deficiency leads to severe combined immunodeficiency (SCID). Previous clinical trials showed that autologous CD34+ cell gene therapy (GT) following busulfan reduced-intensity conditioning is a promising therapeutic approach for ADA-SCID, but long-term data are warranted. Here we report an analysis on long-term safety and efficacy data of 43 patients with ADA-SCID who received retroviral ex vivo bone marrow-derived hematopoietic stem cell GT. Twenty-two individuals (median follow-up 15.4 years) were treated in the context of clinical development or named patient program. Nineteen patients were treated post-marketing authorization (median follow-up 3.2 years), and two additional patients received mobilized peripheral blood CD34+ cell GT. At data cutoff, all 43 patients were alive, with a median follow-up of 5.0 years (interquartile range 2.4-15.4) and 2 years intervention-free survival (no need for long-term enzyme replacement therapy or allogeneic hematopoietic stem cell transplantation) of 88% (95% confidence interval 78.7-98.4%). Most adverse events/reactions were related to disease background, busulfan conditioning or immune reconstitution; the safety profile of the real world experience was in line with premarketing cohort. One patient from the named patient program developed a T cell leukemia related to treatment 4.7 years after GT and is currently in remission. Long-term persistence of multilineage gene-corrected cells, metabolic detoxification, immune reconstitution and decreased infection rates were observed. Estimated mixed-effects models showed that higher dose of CD34+ cells infused and younger age at GT affected positively the plateau of CD3+ transduced cells, lymphocytes and CD4+ CD45RA+ naive T cells, whereas the cell dose positively influenced the final plateau of CD15+ transduced cells. These long-term data suggest that the risk-benefit of GT in ADA remains favorable and warrant for continuing long-term safety monitoring. Clinical trial registration: NCT00598481 , NCT034786

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Introduzione. Tra editoria e universit\ue0. I risultati del gruppo di lavoro Universit\ue0 di Verona, CINECA e Aie

Nel corso del 2015 l\u2019Universit\ue0 di Verona, con la partnership del consorzio interuniversitario CINECA e di Aie, ha coordinato un progetto di ricerca volto a promuovere la collaborazione fra atenei tramite la creazione di dottorati congiunti e la condivisione delle tesi di dottorato, ponendo al contempo le basi per lo studio delle problematiche connesse all\u2019utilizzo dei file delle pubblicazioni degli editori all\u2019interno degli archivi di ateneo.L\u2019iniziativa, intitolata Dottorato congiunto con enti di ricerca accreditati VQR e messa in condivisione delle tesi di dottorato tra Universit\ue0 degli studi di Verona e atenei partner secondo la politica Open Access con il contributo tecnico di CINECA attraverso la specializzazione del portale PLEIADI, si \ue8 conclusa con la pubblicazione dei risultati del lavoro di ricerca condotto lungo il progetto, che raccolgono i contributi di ciascun partner

Tra editoria e universit\ue0. I risultati del gruppo di lavoro Universit\ue0 di Verona, CINECA e Aie

Nel corso del 2015 l\u2019Universit\ue0 di Verona, con la partnership del consorzio interuniversitario CINECA e di Aie, ha coordinato un progetto di ricerca volto a promuovere la collaborazione fra atenei tramite la creazione di dottorati congiunti e la condivisione delle tesi di dottorato, ponendo al contempo le basi per lo studio delle problematiche connesse all\u2019utilizzo dei file delle pubblicazioni degli editori all\u2019interno degli archivi di ateneo.L\u2019iniziativa, intitolata Dottorato congiunto con enti di ricerca accreditati VQR e messa in condivisione delle tesi di dottorato tra Universit\ue0 degli studi di Verona e atenei partner secondo la politica Open Access con il contributo tecnico di CINECA attraverso la specializzazione del portale PLEIADI, si \ue8 conclusa con la pubblicazione dei risultati del lavoro di ricerca condotto lungo il progetto, che raccolgono i contributi di ciascun partner