412 research outputs found
Tsunamis and tectonic deformation at the northern Cascadia margin: A 3000 year record from Deserted Lake
Abstract: Three layers of sand occur within a sequence of muddy gyttja in a 3 m core recovered from Deserted Lake, which lies at the head of a fjord on the central west coast of Vancouver Island, British Columbia, Canada. The sedimentology and microfossil assemblages of these layers are consistent with deposition by tsunamis. Radiocarbon ages suggest that the tsunamis were generated by plate-boundary earthquakes at the Cascadia subduction zone about 2600, 1600 and 300 years ago. Diatom and protozoan contents of the gyttja layers indicate that relative sea level fell in the periods between tsunamis. The sea-level changes are probably a product of interseismic uplift of the North America plate margin. Post-tsunami diatom and protozoan assemblages are generally more marine than their pre-tsunami counterparts, suggesting that the study site subsided during earthquakes. Estimates of interseismic and coseismic deformation during one earthquake cycle indicate that less than half of the interseismic uplift was recovered during the earthquake, leading to cumulative, or permanent, uplift of the area
Rendezvous of Heterogeneous Mobile Agents in Edge-weighted Networks
We introduce a variant of the deterministic rendezvous problem for a pair of
heterogeneous agents operating in an undirected graph, which differ in the time
they require to traverse particular edges of the graph. Each agent knows the
complete topology of the graph and the initial positions of both agents. The
agent also knows its own traversal times for all of the edges of the graph, but
is unaware of the corresponding traversal times for the other agent. The goal
of the agents is to meet on an edge or a node of the graph. In this scenario,
we study the time required by the agents to meet, compared to the meeting time
in the offline scenario in which the agents have complete knowledge
about each others speed characteristics. When no additional assumptions are
made, we show that rendezvous in our model can be achieved after time in a -node graph, and that such time is essentially in some cases
the best possible. However, we prove that the rendezvous time can be reduced to
when the agents are allowed to exchange bits of
information at the start of the rendezvous process. We then show that under
some natural assumption about the traversal times of edges, the hardness of the
heterogeneous rendezvous problem can be substantially decreased, both in terms
of time required for rendezvous without communication, and the communication
complexity of achieving rendezvous in time
Byzantine Gathering in Networks
This paper investigates an open problem introduced in [14]. Two or more
mobile agents start from different nodes of a network and have to accomplish
the task of gathering which consists in getting all together at the same node
at the same time. An adversary chooses the initial nodes of the agents and
assigns a different positive integer (called label) to each of them. Initially,
each agent knows its label but does not know the labels of the other agents or
their positions relative to its own. Agents move in synchronous rounds and can
communicate with each other only when located at the same node. Up to f of the
agents are Byzantine. A Byzantine agent can choose an arbitrary port when it
moves, can convey arbitrary information to other agents and can change its
label in every round, in particular by forging the label of another agent or by
creating a completely new one.
What is the minimum number M of good agents that guarantees deterministic
gathering of all of them, with termination?
We provide exact answers to this open problem by considering the case when
the agents initially know the size of the network and the case when they do
not. In the former case, we prove M=f+1 while in the latter, we prove M=f+2.
More precisely, for networks of known size, we design a deterministic algorithm
gathering all good agents in any network provided that the number of good
agents is at least f+1. For networks of unknown size, we also design a
deterministic algorithm ensuring the gathering of all good agents in any
network but provided that the number of good agents is at least f+2. Both of
our algorithms are optimal in terms of required number of good agents, as each
of them perfectly matches the respective lower bound on M shown in [14], which
is of f+1 when the size of the network is known and of f+2 when it is unknown
Iodoarene-Catalyzed Cyclizations of Unsaturated Amides
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible
Anonymous Graph Exploration with Binoculars
International audienceWe investigate the exploration of networks by a mobile agent. It is long known that, without global information about the graph, it is not possible to make the agent halts after the exploration except if the graph is a tree. We therefore endow the agent with binoculars, a sensing device that can show the local structure of the environment at a constant distance of the agent current location.We show that, with binoculars, it is possible to explore and halt in a large class of non-tree networks. We give a complete characterization of the class of networks that can be explored using binoculars using standard notions of discrete topology. This class is much larger than the class of trees: it contains in particular chordal graphs, plane triangulations and triangulations of the projective plane. Our characterization is constructive, we present an Exploration algorithm that is universal; this algorithm explores any network explorable with binoculars, and never halts in non-explorable networks
ÉTUDE EXPÉRIMENTALE ET THÉORIQUE DES NOYAUX DE TRANSITION 68,70,72,74Ge
Les isotopes de 68,70,72,74Ge ont été étudiés avec une haute résolution en énergie au moyen de la réaction (p, t). Un grand nombre de nouveaux niveaux 0+, 2+ et 4+ à basse énergie ont été mis en évidence. Des calculs semi-microscopiques de surfaces d'énergie potentielle et de spectres ont été effectués et des conclusions sont données sur la structure des noyaux Ge
Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice
<p>Abstract</p> <p>Background</p> <p>Among patients with cystic fibrosis (CF), females have worse pulmonary function and survival than males, primarily due to chronic lung inflammation and infection with <it>Pseudomonas aeruginosa </it>(<it>P. aeruginosa</it>). A role for gender hormones in the causation of the CF "gender gap" has been proposed. The female gender hormone 17β-estradiol (E2) plays a complex immunomodulatory role in humans and in animal models of disease, suppressing inflammation in some situations while enhancing it in others. Helper T-cells were long thought to belong exclusively to either T helper type 1 (Th1) or type 2 (Th2) lineages. However, a distinct lineage named Th17 is now recognized that is induced by interleukin (IL)-23 to produce IL-17 and other pro-inflammatory Th17 effector molecules. Recent evidence suggests a central role for the IL-23/IL-17 pathway in the pathogenesis of CF lung inflammation. We used a mouse model to test the hypothesis that E2 aggravates the CF lung inflammation that occurs in response to airway infection with <it>P. aeruginosa </it>by a Th17-mediated mechanism.</p> <p>Results</p> <p>Exogenous E2 caused adult male CF mice with pneumonia due to a mucoid CF clinical isolate, the <it>P. aeruginosa </it>strain PA508 (PA508), to develop more severe manifestations of inflammation in both lung tissue and in bronchial alveolar lavage (BAL) fluid, with increased total white blood cell counts and differential and absolute cell counts of polymorphonuclear leukocytes (neutrophils). Inflammatory infiltrates and mucin production were increased on histology. Increased lung tissue mRNA levels for IL-23 and IL-17 were accompanied by elevated protein levels of Th17-associated pro-inflammatory mediators in BAL fluid. The burden of PA508 bacteria was increased in lung tissue homogenate and in BAL fluid, and there was a virtual elimination in lung tissue of mRNA for lactoferrin, an antimicrobial peptide active against <it>P. aeruginosa </it>in vitro.</p> <p>Conclusions</p> <p>Our data show that E2 increases the severity of PA508 pneumonia in adult CF male mice, and suggest two potential mechanisms: enhancement of Th17-regulated inflammation and suppression of innate antibacterial defences. Although this animal model does not recapitulate all aspects of human CF lung disease, our present findings argue for further investigation of the effects of E2 on inflammation and infection with <it>P. aeruginosa </it>in the CF lung.</p
Treatment of dairy cows with PGF2α or NSAID, in combination with antibiotics, in cases of postpartum uterine inflammation
Health-related quality of life in children with cystic fibrosis: validation of the German CFQ-R
Characterization of Glucose Oxidase-Modified Poly(phenylenediamine)-Coated Electrodes in vitro and in vivo: Homogeneous Interference by Ascorbic Acid in Hydrogen Peroxide Detection
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