797 research outputs found
Biomedical applications of aerospace-generated technology Quarterly report, 1 Sep. - 30 Nov. 1968
Biomedical applications of aerospace generated technolog
Biomedical applications of aerospace- generated technology Quarterly report, 1 Dec. 1968 - 28 Feb. 1969
Biomedical applications team for transferring aerospace generated technology to nonaerospace biomedical fiel
Point-contact spectroscopy in heavy-fermion superconductors
We develop a minimal model to calculate point-contact spectra between a
metallic tip and a superconducting heavy-fermion system. We apply our tunneling
model to the heavy fermion CeCoIn5, both in the normal and superconducting
state. In point-contact and scanning tunneling spectroscopy many heavy-fermion
materials, like CeCoIn5, exhibit an asymmetric differential conductance, dI/dV,
combined with a strongly suppressed Andreev reflection signal in the
superconducting state. We argue that both features may be explained in terms of
a multichannel tunneling model in the presence of localized states near the
interface. We find that it is not sufficient to tunnel into two itinerant bands
of light and heavy electrons to explain the Fano line shape of the differential
conductance. Localized states in the bulk or near the interface are an
essential component for quantum interference to occur when an electron tunnels
from the metallic tip of the point contact into the heavy-fermion system.Comment: 13 pages, 9 figures. Accepted for publication in Physical Review
Biomedical applications of aerospace generated technology, task 1 Final report, 1 Jun. 1968 - 31 May 1969
Biomedical applications of aerospace generated technolog
A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients
Introduction
Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients.
Methods
A total of 82 early RA patients (disease duration < 1 year) were followed for 12 months. Clinical assessments, X-rays of hands and magnetic resonance imaging (MRI) of the dominant wrist were assessed at baseline and after 3, 6 and 12 months. The X-rays were scored according to the van der Heijde modified Sharp score (vdHSS). Cytokine analyses were performed with multiplex technology. Associations between cytokines and radiographic progression were examined by logistic regression.
Results
In all, 49% of the patients developed radiographic progression. The median (interquartile range (IQR)) baseline eotaxin level (pg/ml) was significantly lower in patients with (193 (119 to 247)) than without progression (265 (166 to 360)). In the univariate logistic regression analyses, eotaxin was negatively associated to radiographic progression, and this association was maintained in the multivariate model with an odds ratio (OR) (95% confidence interval (CI)) for progression of 0.58 (0.41 to 0.82) per 50 pg/ml increase in eotaxin level. None of the other measured cytokines showed any association to radiographic progression.
Conclusion
This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients
Local Anisotropy of Fluids using Minkowski Tensors
Statistics of the free volume available to individual particles have
previously been studied for simple and complex fluids, granular matter,
amorphous solids, and structural glasses. Minkowski tensors provide a set of
shape measures that are based on strong mathematical theorems and easily
computed for polygonal and polyhedral bodies such as free volume cells (Voronoi
cells). They characterize the local structure beyond the two-point correlation
function and are suitable to define indices of
local anisotropy. Here, we analyze the statistics of Minkowski tensors for
configurations of simple liquid models, including the ideal gas (Poisson point
process), the hard disks and hard spheres ensemble, and the Lennard-Jones
fluid. We show that Minkowski tensors provide a robust characterization of
local anisotropy, which ranges from for vapor
phases to for ordered solids. We find that for fluids,
local anisotropy decreases monotonously with increasing free volume and
randomness of particle positions. Furthermore, the local anisotropy indices
are sensitive to structural transitions in these simple
fluids, as has been previously shown in granular systems for the transition
from loose to jammed bead packs
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