469 research outputs found
State coercion and worker solidarity in Italy (1915-1918): the moral and political content of social unrest
Effects of boundary conditions on irreversible dynamics
We present a simple one-dimensional Ising-type spin system on which we define
a completely asymmetric Markovian single spin-flip dynamics. We study the
system at a very low, yet non-zero, temperature and we show that for empty
boundary conditions the Gibbs measure is stationary for such dynamics, while
introducing in a single site a condition the stationary measure changes
drastically, with macroscopical effects. We achieve this result defining an
absolutely convergent series expansion of the stationary measure around the
zero temperature system. Interesting combinatorial identities are involved in
the proofs
Trans-nasal endoscopic and intra-oral combined approach for odontogenic cysts
Maxillary cysts are a common finding in maxillofacial surgery, dentistry and otolaryngology. Treatment is surgical; a traditional approach includes Caldwell-Luc and other intra-oral approaches. In this article, we analyse the outcomes of 9 patients operated on using a combined intra-oral and trans-nasal approach to the aforementioned disease. Although the number of patients is small, the good results of this study suggest that the combined approach might be a reliable treatment option
“Less invasive” surgery in the treatment of cutaneous chronic ulcers of the lower limb in elderly
The antagonism of the prokineticin system counteracts bortezomib induced side effects: Focus on mood alterations
The development of neuropathy and of mood alterations is frequent after chemotherapy. These complications, independent from the antitumoral mechanism, are interconnected due to an overlapping in their processing pathways and a common neuroinflammatory condition. This study aims to verify whether in mice the treatment with the proteasome inhibitor bortezomib (BTZ), at a protocol capable of inducing painful neuropathy, is associated with anxiety, depression and supraspinal neuroinflammation. We also verify if the therapeutic treatment with the antagonist of the prokineticin (PK) system PC1, which is known to contrast pain and neuroinflammation, can prevent mood alterations. Mice were treated with BTZ (0.4 mg/kg three times/week for 4 weeks); mechanical allodynia and locomotor activity were evaluated over time while anxiety (dark light and marble burying test), depression (sucrose preference and swimming test) and supraspinal neuroinflammation were checked at the end of the protocol. BTZ treated neuropathic mice develop anxiety and depression. The presence of mood alterations is related to the presence of neuroinflammation and PK system activation in prefrontal cortex, hippocampus and hypothalamus with high levels of PK2 and PKR2 receptor, IL‐6 and TNF‐α, TLR4 and an upregulation of glial markers. PC1 treatment, counteracting pain, prevented the development of supraspinal inflammation and depression‐like behavior in BTZ mice
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