Controls on the location of compressional deformation on the NW European margin

The distribution of Cenozoic compressional structures along the NW European margin has been compared with maps of the thickness of the crystalline crust derived from a compilation of seismic refraction interpretations and gravity modelling, and with the distribution of high-velocity lower crust and/or partially serpentinized upper mantle detected by seismic experiments. Only a subset of the mapped compressional structures coincide with areas susceptible to lithospheric weakening as a result of crustal hyperextension and partial serpentinization of the upper mantle. Notably, partially serpentinized upper mantle is well documented beneath the central part of the southern Rockall Basin, but compressional features are sparse in that area. Where compressional structures have formed but the upper mantle is not serpentinized, simple rheological modelling suggests an alternative weakening mechanism involving ductile lower crust and lithospheric decoupling. The presence of pre-existing weak zones (associated with the properties of the gouge and overpressure in fault zones) and local stress magnitude and orientation are important contributing factors

A review of the NE Atlantic conjugate margins based on seismic refraction data

The NE Atlantic region evolved through several rift episodes, leading to break-up in the Eocene that was associated with voluminous magmatism along the conjugate margins of East Greenland and NW Europe. Existing seismic refraction data provide good constraints on the overall tectonic development of the margins, despite data gaps at the NE Greenland shear margin and the southern Jan Mayen microcontinent. The maximum thickness of the initial oceanic crust is 40 km at the Greenland–Iceland–Faroe Ridge, but decreases with increasing distance to the Iceland plume. High-velocity lower crust interpreted as magmatic underplating or sill intrusions is observed along most margins but disappears north of the East Greenland Ridge and the Lofoten margin, with the exception of the Vestbakken Volcanic Province at the SW Barents Sea margin. South of the narrow Lofoten margin, the European side is characterized by wide margins. The opposite trend is seen in Greenland, with a wide margin in the NE and narrow margins elsewhere. The thin crust beneath the basins is generally underlain by rocks with velocities of >7 km s−1 interpreted as serpentinized mantle in the Porcupine and southern Rockall basins; while off Norway, alternative interpretations such as eclogite bodies and underplating are also discussed

Moho and basement depth in the NE Atlantic Ocean based on seismic refraction data and receiver functions

Seismic refraction data and results from receiver functions were used to compile the depth to the basement and Moho in the NE Atlantic Ocean. For interpolation between the unevenly spaced data points, the kriging technique was used. Free-air gravity data were used as constraints in the kriging process for the basement. That way, structures with little or no seismic coverage are still presented on the basement map, in particular the basins off East Greenland. The rift basins off NW Europe are mapped as a continuous zone with basement depths of between 5 and 15 km. Maximum basement depths off NE Greenland are 8 km, but these are probably underestimated. Plate reconstructions for Chron C24 (c. 54 Ma) suggest that the poorly known Ammassalik Basin off SE Greenland may correlate with the northern termination of the Hatton Basin at the conjugate margin. The most prominent feature on the Moho map is the Greenland–Iceland–Faroe Ridge, with Moho depths >28 km. Crustal thickness is compiled from the Moho and basement depths. The oceanic crust displays an increased thickness close to the volcanic margins affected by the Iceland plume

Constraints on s→dγs\to d \gamma from Radiative Hyperon and Kaon Decays

The quark-level process $b \to s \gamma$ has been used extensively to place constraints on new interactions. These same interactions can be further constrained from the enhancement they induce in the quark-level $s \to d \gamma$ transition, to the extent that the short distance contributions can be separated from the long distance contributions. We parameterize what is known about the long distance amplitudes and subtract it from the data in radiative hyperon and kaon decays to constrain new interactions.Comment: Latex 11 page

The standard model at low energies

The hadronic sector of the standard model at low energies is described by a non--decoupling effective field theory, chiral perturbation theory. An introduction is given to the construction of effective chiral Lagrangians, both in the purely mesonic sector and with inclusion of baryons. The connection between the relativistic formulation and the heavy baryon approach to chiral perturbation theory with baryons is reviewed.Comment: Lectures given at the 6th Indian-Summer School on Intermediate Energy Physics, Prague, Aug. 1993, Latex, 26 pages (with a4.sty), UWThPh-1993-3

Structural insights into crista junction formation by the Mic60-Mic19 complex

Mitochondrial cristae membranes are the oxidative phosphorylation sites in cells. Crista junctions (CJs) form the highly curved neck regions of cristae and are thought to function as selective entry gates into the cristae space. Little is known about how CJs are generated and maintained. We show that the central coiled-coil (CC) domain of the mitochondrial contact site and cristae organizing system subunit Mic60 forms an elongated, bow tie–shaped tetrameric assembly. Mic19 promotes Mic60 tetramerization via a conserved interface between the Mic60 mitofilin and Mic19 CHCH (CC-helix-CC-helix) domains. Dimerization of mitofilin domains exposes a crescent-shaped membrane-binding site with convex curvature tailored to interact with the curved CJ neck. Our study suggests that the Mic60-Mic19 subcomplex traverses CJs as a molecular strut, thereby controlling CJ architecture and function

Search for the K(L) --> PI0 PI0 E+ E- Decay in the KTeV Experiment

The recent discovery of a large CP violating asymmetry in K(L) --> PI+ PI- E+ E- mode has prompted us to seach for the associated K(L) --> PI0 PI0 E+ E- decay mode in the KTeV-E799 experiment at Fermilab. In 2.7E+11 K(L) decays, one candidate event has been observed with an expected background of 0.3 event, resulting in an upper limit for the K(L) --> PI0 PI0 E+ E- branching ratio of 6.6E-09 at the 90% confidence level.Comment: To be published in Phys. Rev. Let

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism.OA was induced by meniscectomy (MNX) in ovariectomized osteopenic mice (OP) treated with estradiol (E2), pamidronate (PAM), or phosphate buffered saline (PBS) for 6 weeks. We assessed the subchondral bone and cartilage structure and the expression of cartilage matrix proteases. To assess the involvement of bone soluble factors in cartilage metabolism, supernatant of human bone explants pre-treated with E2 or PAM were transferred to cartilage explants to assess proteoglycan release and aggrecan cleavage. OPG/RANKL mRNA expression was assessed in bone explants by real-time quantitative PCR. The role of osteoprotegerin (OPG) in the bone-cartilage crosstalk was tested using an OPG neutralizing antibody.Bone mineral density of OP mice and osteoclast number were restored by E2 and PAM (p<0.05). In OP mice, E2 and PAM decreased ADAMTS-4 and -5 expression, while only PAM markedly reduced OA compared to PBS (2.0±0.63 vs 5.2±0.95; p<0.05). OPG/RANKL mRNA was increased in human bone explants treated with both drugs (2.2-3.7-fold). Moreover, supernatants from bone explants cultured with E2 or PAM reduced aggrecan cleavage and cartilage proteoglycan release (73±8.0% and 80±22% of control, respectively, p<0.05). This effect was reversed with osteoprotegerin blockade.The inhibition of bone resorption by pamidronate in osteopenic mice alleviates the histological OA score with a reduction in the expression of aggrecanases. Bone soluble factors, such as osteoprotegerin, impact the cartilage response to catabolic factors. This study further highlights the importance of subchondral bone in the regulation of joint cartilage damage in OA

Electrocardiographic changes in a rare case of flecainide poisoning: a case report

Flecainide is a class Ic anti - arrhythmic drug with sodium channel blocking activities. We report a case of a 57 year - old woman who attempted a suicide by ingesting approximately 1,8 gr of flecainide. On the surface electrocardiogram this results in a large QRS complex and in prolongation of the QTc interval. Overdose with a class Ic drug is very uncommon, its management is difficult and the mortality high