1,391 research outputs found
Correlated exponential functions in high precision calculations for diatomic molecules
Various properties of the general two-center two-electron integral over the
explicitly correlated exponential function are analyzed for the potential use
in high precision calculations for diatomic molecules. A compact one
dimensional integral representation is found, which is suited for the numerical
evaluation. Together with recurrence relations, it makes possible the
calculation of the two-center two-electron integral with arbitrary powers of
electron distances. Alternative approach via the Taylor series in the
internuclear distance is also investigated. Although numerically slower, it can
be used in cases when recurrences lose stability. Separate analysis is devoted
to molecular integrals with integer powers of interelectronic distances
and the vanishing corresponding nonlinear parameter. Several methods
of their evaluation are proposed.Comment: 26 pages, includes two tables with exemplary calculation
The eye and the heart
The vasculature of the eye and the heart share several common characteristics. The easily accessible vessels of the eye are therefore—to some extent—a window to the heart. There is interplay between cardiovascular functions and risk factors and the occurrence and progression of many eye diseases. In particular, arteriovenous nipping, narrowing of retinal arteries, and the dilatation of retinal veins are important signs of increased cardiovascular risk. The pressure in the dilated veins is often markedly increased due to a dysregulation of venous outflow from the eye. Besides such morphological criteria, functional alterations might be even more relevant and may play an important role in future diagnostics. Via neurovascular coupling, flickering light dilates capillaries and small arterioles, thus inducing endothelium-dependent, flow-mediated dilation of larger retinal vessels. Risk factors for arteriosclerosis, such as dyslipidaemia, diabetes, or systemic hypertension, are also risk factors for eye diseases such as retinal arterial or retinal vein occlusions, cataracts, age-related macular degeneration, and increases in intraocular pressure (IOP). Functional alterations of blood flow are particularly relevant to the eye. The primary vascular dysregulation syndrome (PVD), which often includes systemic hypotension, is associated with disturbed autoregulation of ocular blood flow (OBF). Fluctuation of IOP on a high level or blood pressure on a low level leads to instable OBF and oxygen supply and therefore to oxidative stress, which is particularly involved in the pathogenesis of glaucomatous neuropathy. Vascular dysregulation also leads to a barrier dysfunction and thereby to small retinal haemorrhage
Heart Failure After Right Ventricular Myocardial Infarction
PURPOSE OF REVIEW
Heart failure (HF) after right ventricular myocardial infarction (RVMI) is common and complicates its clinical course. This review aims to provide a current overview on the characteristic features of RV failure with focus on acute management.
RECENT FINDINGS
While HF after RVMI is classically seen after acute proximal right coronary artery occlusion, RV dysfunction may also occur after larger infarctions in the left coronary artery. Because of its different anatomy and physiology, the RV appears to be more resistant to permanent infarction compared to the LV with greater potential for recovery of ischemic myocardium. Hypotension and elevated jugular pressure in the presence of clear lung fields are hallmark signs of RV failure and should prompt confirmation by echocardiography. Management decisions are still mainly based on small studies and extrapolation of findings from LV failure. Early revascularization improves short- and long-term outcomes. Acute management should further focus on optimization of preload and afterload, maintenance of sufficient perfusion pressures, and prompt management of arrhythmias and concomitant LV failure, if present. In case of cardiogenic shock, use of vasopressors and/or inotropes should be considered along with timely use of mechanical circulatory support (MCS) in eligible patients. HF after RVMI is still a marker of worse outcome in acute coronary syndrome. Prompt revascularization, careful medical therapy with attention to the special physiology of the RV, and selected use of MCS provide the RV the time it needs to recover from the ischemic insult
Chocolat noir ou chocolat blanc? Le cacao et la santé cardiovasculaire
Epidemiological data show that a regular dietary intake of plant-derived foods reduces the risk of cardiovascular disease. Recent research indeed demonstrates interesting data about cocoa consumption, with high concentrations of polyphenols, and beneficial effects on blood pressure, insulin resistance and platelet function. Although still debated, a range of potential mechanisms through which cocoa might exert their benefits on cardiovascular health have been suggested: activation of nitric oxide, antioxidant, anti-inflammatory, anti-platelet effects, which might in turn improve endothelial function, lipid levels, blood pressure and insulin resistance. This article reviews available data about the effects of the consumption of cocoa and different types of chocolate on cardiovascular health, and outlines potential mechanisms involved on the basis of recent studies
Microscopic dynamics of thin hard rods
Based on the collision rules for hard needles we derive a hydrodynamic
equation that determines the coupled translational and rotational dynamics of a
tagged thin rod in an ensemble of identical rods. Specifically, based on a
Pseudo-Liouville operator for binary collisions between rods, the Mori-Zwanzig
projection formalism is used to derive a continued fraction representation for
the correlation function of the tagged particle's density, specifying its
position and orientation. Truncation of the continued fraction gives rise to a
generalised Enskog equation, which can be compared to the phenomenological
Perrin equation for anisotropic diffusion. Only for sufficiently large density
do we observe anisotropic diffusion, as indicated by an anisotropic mean square
displacement, growing linearly with time. For lower densities, the Perrin
equation is shown to be an insufficient hydrodynamic description for hard
needles interacting via binary collisions. We compare our results to
simulations and find excellent quantitative agreement for low densities and
qualtitative agreement for higher densities.Comment: 21 pages, 6 figures, v2: clarifications and improved readabilit
Aligning vocational training to the electromobile transformation by establishing the “training factory stator production” - A methodical deficit analysis with derivation of measures
In addition to the current challenges in production technology due to the shift from conventional powertrains towards electrified drive technologies, the disruptive transformation of mobility confronts OEMs and suppliers with major personnel challenges, which include new requirement profiles for prospective skilled workers. In order to meet the personnel requirements of industry and ensure the high quality of vocational training in Germany nonetheless, the current training concepts must be strengthened by the targeted integration of specific contents and be geared holistically to the needs of new occupational profiles. This paper presents a methodological approach for deriving current deficits in vocational education and training through the systematic analysis of framework curricula and the targeted survey of teachers working at German vocational schools as well as the derived training program to support the qualification of trainees. In order to obtain a training concept of high didactic quality, the approach is based on pedagogical methods to provide the best possible support and to convey the learning objectives related to professional, social, methodical, and personal skills. With the newly conceived “Training Factory Stator Production” at the wbk Institute of Production Science of the Karlsruhe Institute of Technology, a program for the training and further education of trainees, skilled employees and engineers will be introduced using the example of producing stators with hairpin technology, to support especially small and medium-sized companies in the personnel transformation process
Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population
<p>Abstract</p> <p>Background</p> <p>The aim of this epidemiological study was to investigate the relationship of thermal discomfort with cold extremities (TDCE) to age, gender, and body mass index (BMI) in a Swiss urban population.</p> <p>Methods</p> <p>In a random population sample of Basel city, 2,800 subjects aged 20-40 years were asked to complete a questionnaire evaluating the extent of cold extremities. Values of cold extremities were based on questionnaire-derived scores. The correlation of age, gender, and BMI to TDCE was analyzed using multiple regression analysis.</p> <p>Results</p> <p>A total of 1,001 women (72.3% response rate) and 809 men (60% response rate) returned a completed questionnaire. Statistical analyses revealed the following findings: Younger subjects suffered more intensely from cold extremities than the elderly, and women suffered more than men (particularly younger women). Slimmer subjects suffered significantly more often from cold extremities than subjects with higher BMIs.</p> <p>Conclusions</p> <p>Thermal discomfort with cold extremities (a relevant symptom of primary vascular dysregulation) occurs at highest intensity in younger, slimmer women and at lowest intensity in elderly, stouter men.</p
Breakup of the aligned H molecule by xuv laser pulses: A time-dependent treatment in prolate spheroidal coordinates
We have carried out calculations of the triple-differential cross section for
one-photon double ionization of molecular hydrogen for a central photon energy
of ~eV, using a fully {\it ab initio}, nonperturbative approach to solve
the time-dependent \Schro equation in prolate spheroidal coordinates. The
spatial coordinates and are discretized in a finite-element
discrete-variable representation. The wave packet of the laser-driven
two-electron system is propagated in time through an effective short iterative
Lanczos method to simulate the double ionization of the hydrogen molecule. For
both symmetric and asymmetric energy sharing, the present results agree to a
satisfactory level with most earlier predictions for the absolute magnitude and
the shape of the angular distributions. A notable exception, however, concerns
the predictions of the recent time-independent calculations based on the
exterior complex scaling method in prolate spheroidal coordinates
[Phys.~Rev.~A~{\bf 82}, 023423 (2010)]. Extensive tests of the numerical
implementation were performed, including the effect of truncating the Neumann
expansion for the dielectronic interaction on the description of the initial
bound state and the predicted cross sections. We observe that the dominant
escape mode of the two photoelectrons dramatically depends upon the energy
sharing. In the parallel geometry, when the ejected electrons are collected
along the direction of the laser polarization axis, back-to-back escape is the
dominant channel for strongly asymmetric energy sharing, while it is completely
forbidden if the two electrons share the excess energy equally.Comment: 17 pages, 9 figure
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