The Coulomb-Higgs transition of the three-parameter U(1)-Higgs model

We find a first order Coulomb--Higgs phase transition at moderately large values of the coupling $\lambda$, and no evidence for a change of order at any finite value of it.Comment: 3 pages, uuencoded compressed ps file. Contribution to Lattice '9

Mapping of the Tacaribe Arenavirus Z-Protein Binding Sites on the L Protein Identified both Amino Acids within the Putative Polymerase Domain and a Region at the N Terminus of L That Are Critically Involved in Binding

Tacaribe virus (TacV) is the prototype of the New World group of arenaviruses. The TacV genome encodes four proteins: the nucleoprotein (N), the glycoprotein precursor, the polymerase (L), and a RING finger protein (Z). Using a reverse genetics system, we demonstrated that TacV N and L are sufficient to drive transcription and replication mediated by TacV-like RNAs and that Z is a powerful inhibitor of these processes (Lopez et al., J. Virol. 65:12241-12251, 2001). More recently, we provided the first evidence of an interaction between Z and L and showed that Z's inhibitory activity was dependent on its ability to bind to L (Jácamo et al., J. Virol. 77:10383-10393, 2003). In the present study, we mapped the TacV Z-binding sites on the 2,210-amino-acid L polymerase. To that end, we performed deletion analysis and point mutations of L and studied the Z-L interaction by coimmunoprecipitation with specific sera. We found that the C-terminal region of L was not essential for the interaction and identified two noncontiguous regions that were critical for binding: one at the N-terminus of L between residues 156 and 292 and a second one in the polymerase domain (domain III). The importance of domain III in binding was revealed by substitutions in D1188 and H1189 within motif A and in each residue of the conserved SDD sequence (residues 1328, 1329, and 1330) within motif C. Our results showed that of the substituted residues, only H1189 and D1329 appeared to be critically involved in binding Z.Fil: Wilda, Maximiliano. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lopez, Nora Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaFil: Casabona, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein"; ArgentinaFil: Franze Fernandez, Maria T.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Genética y Biología Molecular; Argentin

Memoria del segundo simposium sobre historia, sociedad y cultura de México y América Latina

El objetivo principal de esta ponencia consiste en reflexionar sobre los valores que se evocan en los textos fundamentales de la legislación de la Universidad Autónoma del Estado de México (UAEM). El cuerpo central del texto se divide en tres apartados. En el primero se catalogan dichos valores a partir de una serie de clasificaciones axiológicas de carácter filosófico. En el segundo se interrelacionan los siete valores contemplados: libertad, tolerancia, respeto, autonomía, pensamiento crítico, responsabilidad y solidaridad. Y en el tercero se pone de manifiesto cómo se expresan tales valores en los dos textos principales de la legislación de la UAEM: la Ley de la Universidad Autónoma del Estado de México y el Estatuto universitario de la Universidad Autónoma del Estado de México. También se incluyen en esta ponencia, en sendos anexos, los artículos de ambos textos legales en los que se expresa algún valor cognitivo o ético, anotando a continuación de los artículos en cuestión, entre corchetes, los valores aludidos en ellos. Por último, se indica la bibliografía citada

Differential Flight Muscle Development in Workers, Queens and Males of the Eusocial Bees, Apis mellifera and Scaptotrigona postica

The flight capability of the adult eusocial bees, Apis mellifera L. and Scaptotrigona postica Latreille (Hymenoptera: Apidae), is intrinsically linked to their colonial functions, such as the nuptial flight for mating in the case of queens and males, and the exploration of new habitats for nesting and food sources in the case of workers. Flight is achieved by the contraction of indirect flight muscles that produce changes in thoracic volume and, therefore, wing movement. The purpose of this work is to examine possible differences in muscle development that may be associated with the flying activity of individuals in a given life stage considering the behavioral and physiological differences among the stages and between the two species studied. Measurements of the muscle fibers obtained from light microscopy preparations of muscle were submitted to statistical analysis in order to detect the differences at a given time, or throughout the life of the individual. The results show that muscle morphology is similar in both species, but in A. mellifera the muscle fibers are thicker and more numerous than in S. postica. Differences in the fiber thickness according to life stage in all classes of individuals of both species were detected. These results are discussed in relation to the need for flying in each life stage

Hidden in Plain Sight: Health Discrimination & Avoidance Among the SGM Population

Despite the advancements the American health care system has made to increase access, there still remains the prominent issue of healthcare avoidance. Specifically, the sexual and gender minority (SGM) population remains incredibly vulnerable. This is due to the stigma that those who are not visibly or socially presenting themselves as gender confirming or hetero-normative; they may be denied access to healthcare or may face discrimination in pursuit of proper health care. Current research aims at identifying potential deterrents to receiving health care amongst an emerging and increasing population. Data was collected through an online-survey and distributed through Reddit threads in which participants could respond anonymously to questions regarding SGM issues, but more specifically healthcare avoidance and fear of discrimination. A total of 1316 respondents composed the sample size in this SGM study. Measured variables in this study included: age, education, income, gender, sex assigned at birth, partner status, race, ACES score, and overall healthcare avoidance. Within this study, it was found that ACE scores, gender minority status, income, and fear of discrimination were positively correlated. The results were statistically significant (p \u3c 0.005). The dilemma of health care avoidance among the SGM population is not only evident in research, but also in practice. This community faces some of the highest rates of discrimination inherently and is one of the groups with the largest needs for timely and efficient health care regardless of their sexual preferences or gender expression. It is a primary objective of health care to help those in need, and that includes those who may not be visually conforming or fall within heteronormativity. Further research should be conducted to be more representative of the population, as well as help in reducing further discrimination or fear of discrimination in clinical settings

Antioxidant Capacity and Antimicrobial Activity of Commercial Samples of Guava Leaves (\u3cem\u3ePsidium guajava\u3c/em\u3e)

Psidium guajava is a small tree native to South and Central America. Guava leaves have traditionally been used for treating different illnesses. These benefits can be attributed to phenolics and flavonoids produced by guava. The chemical composition of guava leaf extracts was correlated with biological activity. Total phenolics, total flavonoids, ABTS/DPPH, TZM-bl, plaque reduction, XTT, spectrophotometric and Kirby-Bauer assays were used to test phenols, flavonoids, antioxidant properties, antiviral activity, cytotoxicity, and antibacterial activity, respectively. The median cytotoxicity concentration and half-maximal effective concentration values were obtained in order to determine antiviral selectivity against human immunodeficiency virus type 1 and herpes simplex virus type 1. Antibacterial activity against Escherichia coli and Bacillus subtilis were evaluated using a spectrophotometric assay and Kirby-Bauer test. The guava leaf extracts had a high phenol (0.8 to 2.1 GAE mg/mL) and flavonoid (62.7 to 182.1 Rutin Eq mg/g DW) content that correlated with high antioxidant capacity and selective antiviral activity (therapeutic index values above 10). Results of antibacterial tests indicated that the extracts have activity against gram-negative and gram-positive bacteria

Tycho: Facilitation Support for Groupware User Tests

Running user tests for groupware requires tracking the progress of multiple users performing co-dependent tasks, while facilitating and observing their coordinated actions. This requirement negatively impacts the main objective of user testing, which is detecting usability flaws. User testing of groupware becomes more challenging when run remotely. Even if there are tools for remote user testing that can get the job done for a single user, they are not prepared for collaborative scenarios. In this paper we argue that tool support for the facilitation of user tests of groupware is missing. Consequently, we propose a method for user tests with tool assistance that makes it possible to automate task synchronization, especially for different workflows that must be run concurrently. We evaluated our proposal by comparing it to a manually facilitated approach during on-site coordinated user tests. The results indicate that, while the task of designing and running user tests with tool support takes more time, it allows the testers to better focus on detecting usability problems.Fil: Grigera, Julián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Gardey, Juan Cruz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; ArgentinaFil: Fernandez, Alejandro. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Garrido, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; Argentin

An Integrative Model of Team Learning. Evidence from Corporate Strategy’ Students

The aim of our research is to evaluate simultaneously the working of groups that facilitate group learning and, finally, the accumulation of knowledge using the theoretical basis of team mental model

Metallopanstimulin as a marker for head and neck cancer

BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. PATIENTS AND METHODS: A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay. RESULTS: HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001). CONCLUSION: We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients

Un Modelo de Gestión Tributaria Y su Relación con la Recaudación de los Gobiernos Locales

La presente investigación titulada “UN MODELO DE GESTIÓN TRIBUTARIA Y SU RELACIÓN CON LA RECAUDACIÓN DE LOS GOBIERNOS LOCALES” tiene como objetivo principal, determinar en qué medida un modelo de gestión tributaria se relaciona con la recaudación de los gobiernos locales. El estudio, metodológicamente, es de un enfoque cuantitativo, con un alcance descriptivo explicativo y un diseño de investigación no experimental, con una población de estudio constituida por los funcionarios con responsabilidad estratégica dentro de la Municipalidad Provincial de Huaura, que suman un total de 129 personas, y una muestra de 97 personas, utilizándose un cuestionario tipo Likert, y el uso de la prueba Chi Cuadrado para la demostración de las hipótesis. Durante el desarrollo de la presente investigación se llega a la siguiente conclusión general: Que un modelo de gestión tributaria se relaciona positivamente con la recaudación de los gobiernos locales. Como esquema final del estudio se exponen las recomendaciones a las que se ha llegado, de las cuales se desprende la propuesta de aplicación de estrategias para mejorar la recaudación de los gobiernos locales. Las palabras claves dentro de la investigación son las siguientes: Modelo de gestión tributaria y la recaudación de los gobiernos locales.Tesi