Visualizing and Understanding Convolutional Networks

Large Convolutional Network models have recently demonstrated impressive classification performance on the ImageNet benchmark. However there is no clear understanding of why they perform so well, or how they might be improved. In this paper we address both issues. We introduce a novel visualization technique that gives insight into the function of intermediate feature layers and the operation of the classifier. We also perform an ablation study to discover the performance contribution from different model layers. This enables us to find model architectures that outperform Krizhevsky \etal on the ImageNet classification benchmark. We show our ImageNet model generalizes well to other datasets: when the softmax classifier is retrained, it convincingly beats the current state-of-the-art results on Caltech-101 and Caltech-256 datasets

Whole body interaction

In this workshop we explore the notation of whole body interaction. We bring together different disciplines to create a new research direction for study of this emerging form of interaction

Driver Distraction and Reliance: Adaptive Cruise Control in the Context of Sensor Reliability and Algorithm Limits

This study investigated how system failures influenced drivers’reliance on Adaptive Cruise Control (ACC). A medium-fidelity driving simulatorwas used to evaluate the effect of driving condition (traffic, rain) and automation(manual control, ACC) on headway maintenance and brake response. Inconditions of rain, the signal continuity of the ACC sensors was degraded and inconditions of heavy traffic, the braking limits of the ACC system were exceeded.Dependent variables included response time to lead vehicle (LV) braking, numberof collisions, and both time headway (THW) and time-to-collision (TTC) atinstant of the brake response. Throughout the drive, a continuous (forced-paced)secondary task was introduced to determine how an in-vehicle task interactedwith ACC reliance. Results showed that the failure type influenced driver’sreliance on ACC with drivers relying more on ACC in traffic periods than in rainperiods. ACC appeared to offer a safety benefit when drivers were distracted withcomplex mental tasks in periods of heavy traffic

The logic of fossil fuel bans

Until recently, national bans on fossil fuel-related activities were a taboo subject, but they are now becoming increasingly common. The logic of appropriateness that underpins such bans is key to understanding their normative appeal, and to explaining and predicting their proliferation

Exercise and the microbiota

The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research Grant from Science Foundation Ireland (Grant number 13/SIRG/2160). Dr. Paul Cotter is funded by a Principal Investigator Award from Science Foundation Ireland P.D.C are supported by a SFI PI award (Grant number 11/PI/1137).peer-reviewedSedentary lifestyle is linked with poor health, most commonly obesity and associated disorders, the corollary being that exercise offers a preventive strategy. However, the scope of exercise biology extends well beyond energy expenditure and has emerged as a great ‘polypill’, which is safe, reliable and cost-effective not only in disease prevention but also treatment. Biological mechanisms by which exercise influences homeostasis are becoming clearer and involve multi-organ systemic adaptations. Most of the elements of a modern lifestyle influence the indigenous microbiota but few studies have explored the effect of increased physical activity. While dietary responses to exercise obscure the influence of exercise alone on gut microbiota, professional athletes operating at the extremes of performance provide informative data. We assessed the relationship between extreme levels of exercise, associated dietary habits and gut microbiota composition, and discuss potential mechanisms by which exercise may exert a direct or indirect influence on gut microbiota.The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research Grant from Science Foundation Ireland (Grant number 13/SIRG/2160). Dr. Paul Cotter is funded by a Principal Investigator Award from Science Foundation Ireland P.D.C are supported by a SFI PI award (Grant number 11/PI/1137)

Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge

peer-reviewedLinks between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-induced obese (DIO) mice through manipulation of the gut microbiota with vancomycin or with the bacteriocin-producing probiotic Lactobacillus salivarius UCC118 (Bac+), with metabolic improvement achieved in DIO mice in receipt of vancomycin. However, two phases of weight gain were observed with effects most marked early in the intervention phase. Here, we compare the gut microbial populations at the early relative to the late stages of intervention using a high throughput sequencing-based analysis to understand the temporal relationship between the gut microbiota and obesity. This reveals several differences in microbiota composition over the intervening period. Vancomycin dramatically altered the gut microbiota composition, relative to controls, at the early stages of intervention after which time some recovery was evident. It was also revealed that Bac+ treatment initially resulted in the presence of significantly higher proportions of Peptococcaceae and significantly lower proportions of Rikenellaceae and Porphyromonadaceae relative to the gut microbiota of L. salivarius UCC118 bacteriocin negative (Bac-) administered controls. These differences were no longer evident at the later time. The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota.The authors are supported in part by Teagasc, Science Foundation Ireland (in the form of a research centre grant to the Alimentary Pharmabiotic Centre and PI awards to PWOT and PC) and by Alimentary Health Ltd

Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis

<p>Abstract</p> <p>Background</p> <p>The incidence and diversity of human methanogens are insufficiently characterised in the gastrointestinal tract of both health and disease. A PCR and clone library methodology targeting the <it>mcrA </it>gene was adopted to facilitate the two-fold aim of surveying the relative incidence of methanogens in health and disease groups and also to provide an overview of methanogen diversity in the human gastrointestinal tract.</p> <p>Results</p> <p>DNA faecal extracts (207 in total) from a group of healthy controls and five gastrointestinal disease groups were investigated. Colorectal cancer, polypectomised, irritable bowel syndrome and the control group had largely equivalent numbers of individuals positive for methanogens (range 45–50%). Methanogen incidence in the inflammatory bowel disease groups was reduced, 24% for ulcerative colitis and 30% for Crohn's disease. Four unique <it>mcrA </it>gene restriction fragment length polymorphism profiles were identified and bioinformatic analyses revealed that the majority of all sequences (94%) retrieved from libraries were 100% identical to <it>Methanobrevibacter smithii mcrA </it>gene. In addition, <it>mcrA </it>gene sequences most closely related to <it>Methanobrevibacter oralis </it>and members of the order <it>Methanosarcinales </it>were also recovered.</p> <p>Conclusion</p> <p>The <it>mcrA </it>gene serves as a useful biomarker for methanogen detection in the human gut and the varying trends of methanogen incidence in the human gut could serve as important indicators of intestinal function. Although <it>Methanobrevibacter smithii </it>is the dominant methanogen in both the distal colon of individuals in health and disease, the diversity of methanogens is greater than previously reported. In conclusion, the low incidence of methanogens in Inflammatory Bowel Disease, the functionality of the methanogens and impact of methane production in addition to competitive interactions between methanogens and other microbial groups in the human gastrointestinal tract warrants further investigation.</p

A User-Centred Approach to Reducing Sedentary Behaviour

The use of digital technologies in the administration of healthcare is growing at a rapid rate. However, such platforms are often expensive. As people are living longer, the strain placed on hospitals is increasing. It is evident that a usercentric approach is needed, which aims to prevent illness before a hospital visit is required. As such, with the levels of obesity rising, preventing this illness before such resources are required has the potential to save an enormous amount of time and money, whilst promoting a healthier lifestyle. New and novel approaches are needed, which are inexpensive and pervasive in nature. One such approach is to use human digital memories. This outlet provides visual lifelogs, composed of a variety of data, which can be used to identify periods of inactivity. This paper explores how the DigMem system is used to successfully recognise activity and create temporal memory boxes of human experiences, which can be used to monitor sedentary behaviour

A Smart Framework for Predicting the Onset of Nocturnal Enuresis (PrONE) in Children and Young People

Bed wetting during normal sleep in children and young people has a significant impact on the child and their parents. The condition is known as nocturnal enuresis and its underlying cause has been subject to different explanatory factors that include, neurological, urological, sleep, genetic and psychosocial influences. Several clinical and technological interventions for managing nocturnal enuresis exist that include the clinician’s opinions, pharmacology interventions, and alarm systems. However, most have failed to produce any convincing results; clinical information is often subjective and often inaccurate, the use of desmopression and tricyclic antidepressants only report between 20% and 40% success, and alarms only a 50% success fate. This paper posits an alternative research idea concerned with the early detection of impending involuntary bladder release. The proposed framework is a measurement and prediction system that processes moisture and bladder volume data from sensors fitted into undergarments that are used by patients suffering with nocturnal enuresis. The proposed framework represents a level of sophistication and accuracy in nocturnal enuresis treatment not previously considered