<i>N</i>‑(6-Methyl-2-pyridyl)mesitylenesulfonamide: An Efficient Template for Polyiodides

A series of (poly-)­iodides featuring I^–, I₃^–, I₅^–, and I₇^– anions and even the challenging I₄^2– dianion have been synthesized and structurally characterized by X-ray diffraction. The V-shaped sulfapyridine derivative <i>N</i>-(6-methyl-2-pyridyl)­mesitylenesulfonamide acts as the countercation in all compounds. Depending on stoichiometry and solvent, the different products are reproducibly accessible as phase-pure solids. N–H···I hydrogen bonds connect cations and iodide or triiodide anions to salts with related packing features. The same interactions allow for the stabilization of the much less popular tetraiodide, subtending this linear species between two cations. Monocationic pairs of (formally hemiprotonated) sulfonamides pack according to a common pattern and exert a pronounced templating effect on the formation of penta- and heptaiodides; their influence is based on charge, size, and shape matching. The higher polyiodides can readily be discerned by their Raman spectra

Switching from Bonding to Nonbonding: Temperature-Dependent Metal Coordination in a Zinc(II) Sulfadiazine Complex

The metal coordination in the mononuclear complex diamminebis­(sulfadiazine)­zinc shows a unique temperature dependence: High-resolution diffraction data prove that the coordination is almost tetrahedral at 100 K, whereas a fifth longer interaction becomes relevant at 200 K. The change in the geometry is fully reversible and is also reflected in the charge density of the compound

Switching from Bonding to Nonbonding: Temperature-Dependent Metal Coordination in a Zinc(II) Sulfadiazine Complex

The metal coordination in the mononuclear complex diamminebis­(sulfadiazine)­zinc shows a unique temperature dependence: High-resolution diffraction data prove that the coordination is almost tetrahedral at 100 K, whereas a fifth longer interaction becomes relevant at 200 K. The change in the geometry is fully reversible and is also reflected in the charge density of the compound

Table_1_The effect of cognitive rehabilitation on daily functioning of patients with Alzheimer’s disease: a systematic review and meta-analysis of clinical trials.docx

BackgroundAlzheimer’s disease (AD) is the most prevalent type of dementia and represents 60–80% of dementia cases. AD affects over 32 million people globally, and 8.1% of affected females and 5.4% of affected males were older than 65 years. Cognitive rehabilitation focuses on helping patients develop individualized strategies to obtain or maintain optimal functioning. As of now, there is no complete and systematic meta-analysis on the effects of cognitive rehabilitation on cognitive functioning in AD patients.ObjectivesTo provide the most recent and extensive pooled analysis and evidence and explore the influence of cognitive rehabilitation on overall cognitive functioning in patients with AD.MethodsWe searched articles through several databases such as PubMed, Cochrane Library, Embase, and Web of Science, from the inception to June 2023. Studies on cognitive stimulation, cognitive training, and cognitive interventions, and non-English articles were excluded. The outcome measures encompassed the effects of cognitive rehabilitation on the overall cognitive functioning of people with AD (e.g., verbal fluency, behavioral memory, neuropsychiatric status and occupational performance levels).ResultsA total of 14 clinical trials were included in this analysis. The meta-analysis showed that cognitive rehabilitation significantly improved quality of life (WMD: 2.87; 95% CI: 0.79, 4.95; p = 0.007) and occupational performance levels (WMD: 1.53; 95% CI: 0.43, 2.63; p = 0.007) in patients with AD. However, it did not show a significant effect on other domains of specific cognitive functions in patients with AD.ConclusionCognitive rehabilitation exhibited a moderate to large impact on both quality of life and occupational performance levels in people with AD. Future studies are required to explore the potential of various cognitive interventions across specific domains, so as to provide more insights into the management of AD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023444390.</p

Table_2_The effect of cognitive rehabilitation on daily functioning of patients with Alzheimer’s disease: a systematic review and meta-analysis of clinical trials.DOCX

BackgroundAlzheimer’s disease (AD) is the most prevalent type of dementia and represents 60–80% of dementia cases. AD affects over 32 million people globally, and 8.1% of affected females and 5.4% of affected males were older than 65 years. Cognitive rehabilitation focuses on helping patients develop individualized strategies to obtain or maintain optimal functioning. As of now, there is no complete and systematic meta-analysis on the effects of cognitive rehabilitation on cognitive functioning in AD patients.ObjectivesTo provide the most recent and extensive pooled analysis and evidence and explore the influence of cognitive rehabilitation on overall cognitive functioning in patients with AD.MethodsWe searched articles through several databases such as PubMed, Cochrane Library, Embase, and Web of Science, from the inception to June 2023. Studies on cognitive stimulation, cognitive training, and cognitive interventions, and non-English articles were excluded. The outcome measures encompassed the effects of cognitive rehabilitation on the overall cognitive functioning of people with AD (e.g., verbal fluency, behavioral memory, neuropsychiatric status and occupational performance levels).ResultsA total of 14 clinical trials were included in this analysis. The meta-analysis showed that cognitive rehabilitation significantly improved quality of life (WMD: 2.87; 95% CI: 0.79, 4.95; p = 0.007) and occupational performance levels (WMD: 1.53; 95% CI: 0.43, 2.63; p = 0.007) in patients with AD. However, it did not show a significant effect on other domains of specific cognitive functions in patients with AD.ConclusionCognitive rehabilitation exhibited a moderate to large impact on both quality of life and occupational performance levels in people with AD. Future studies are required to explore the potential of various cognitive interventions across specific domains, so as to provide more insights into the management of AD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023444390.</p

Concerted Halogen-Bonded Networks with <i>N</i>‑Alkyl Ammonium Resorcinarene Bromides: From Dimeric Dumbbell to Capsular Architectures

<i>N</i>-Alkyl ammonium resorcinarene bromides and 1,4-diiodooctafluorobutane via multiple intermolecular halogen bonds (XB) form different exotic supramolecular architectures through subtle changes of the upper rim substituents. Dimeric dumbbell-like assembly with encapsulated guest molecules is generated with <i>N</i>-benzyl substituents. The <i>N</i>-hexyl groups engender an XB-induced polymeric pseudocapsule and an XB-induced dimeric capsule with entrapped 1,4-dioxane guest molecules. The <i>N</i>-propyl and <i>N</i>-cyclohexyl groups generate deep cavity cavitands. The deep cavity cavitands possess cavities for self-inclusion leading to polymeric herringbone arrangement in one direction and that pack into 3D polymeric arrangement resembling egg crate-like supramolecular networks. These assemblies are studied in solution via NMR spectroscopy and in the solid state via X-ray crystallography

Hierarchical Ordering in Ternary Co-Crystals of C₆₀, <i>N</i>‑Benzyl Ammonium Resorcinarene Bromide and Solvent Molecules

Co-crystallization of C₆₀ together with an <i>N</i>-benzyl ammonium resorcinarene bromide from toluene:1,2-dichloroethane mixture results in ternary co-crystals where the modulated C₆₀ lattice entraps dimeric resorcinarene assemblies, which, in turn, have 149 and 280 ų cavities filled with 1,2-dichloroethane molecules

Ruthenium Catalyzed Hydroboration of Terminal Alkynes to <i>Z</i>‑Vinylboronates

The nonclassical ruthenium hydride pincer complex [Ru­(PNP)­(H)₂(H₂)] <b>1</b> (PNP = 1,3-bis­(di-<i>tert</i>-butyl-phosphinomethyl)­pyridine) catalyzes the <i>anti</i>-Markovnikov addition of pinacolborane to terminal alkynes yielding <i>Z</i>-vinylboronates at mild conditions. The complex [Ru­(PNP)­(H)₂(HBpin)] <b>2</b> (HBpin = pinacolborane), which was identified at the end of the reaction and prepared independently, is proposed as the direct precursor to the catalytic cycle involving rearrangement of coordinated alkyne to <i>Z</i>-vinylidene as a key step for the apparent <i>trans</i>-hydroboration

Visible-Light Photoredox-Catalyzed Synthesis of Nitrones: Unexpected Rate Acceleration by Water in the Synthesis of Isoxazolidines

A new oxidative [3 + 2] cycloaddition of <i>N</i>-substituted hydroxylamines with alkenes was established under visible light photoredox catalysis. This novel protocol provides a rapid, mild, and efficient access to valuable five-membered ring isoxazolidine heterocycles in a concise fashion

Guest-Induced Folding of the <i>N</i>‑Benzyl Substituents in an Ammonium Resorcinarene Chloride and the Formation of a Halogen-Bonded Dimer of Capsules

In methanol, <i>N</i>-benzyl ammonium resorcinarene chloride (Bn-NARCl) crystallizes as a solvate with the benzyl groups oriented in an open flower-like manner parallel to the cation–anion seam. 1,4-Dioxane as guest triggers a “semi-closed” single-molecule capsule with two benzyl “arms” enclosing the guest. The introduction of halogen bond (XB) donor 1,4-diiodoperfluorobutane (1,4-DIOFB) additionally folds the remaining two benzyl arms thus resulting in a fully closed capsule. Two 1,4-DIOFB molecules bridge two such Bn-NARCl capsules, forming a 2:2:2 XB held dimeric assembly of single-molecule capsules. The peculiar behavior was not observed in the bromide analog under similar experimental conditions. The studies were performed in solid state by X-ray single crystal crystallography, and MM level theoretical calculations