Visible-Light Photoredox-Catalyzed Synthesis of Nitrones: Unexpected Rate Acceleration by Water in the Synthesis of Isoxazolidines

Abstract

A new oxidative [3 + 2] cycloaddition of <i>N</i>-substituted hydroxylamines with alkenes was established under visible light photoredox catalysis. This novel protocol provides a rapid, mild, and efficient access to valuable five-membered ring isoxazolidine heterocycles in a concise fashion