Energy demand modeling and forecast of monoblocco building at the city hospital of genova according to different retrofit scenarios

Buildings are one of the major energy consumers. Thus, it is crucial to develop new solutions in order to retrofit existent buildings (especially for public buildings), achieving both energy saving and environmental protection. The proposed solutions are in many cases expensive and it is necessary to evaluate them case by case. The present analysis focuses on the development of a methodology useful to select and evaluate different energy retrofitting solutions and it is applied to energy simulations of the Monoblocco Pavilion at the San Martino Hospital in Genova, Italy. The model allows to evaluate the building heating and cooling loads and to predict the energy requests associated to different retrofit scenarios. The selected retrofit technologies include some innovative solutions such as fa\ue7ade super insulated void panel, smart rotating windows with different emissivity glass and sunlight carrying optic-fiber coupled with dimmed LED lighting system. Results have been analyzed in terms of hourly values of selected variables and the different effects related to the retrofit strategies have been compared in terms of energy saving. The comparison included also the Simple Pay Back Period (SPB) of the investment in order to identify the best technologies combination also from an economic point of view

Estimating the mass of CMEs from the analysis of EUV dimmings

Context. Reliable estimates of the mass of coronal mass ejections (CMEs) are required to quantify their energy and predict how they affect space weather. When a CME propagates near the observer's line of sight, these tasks involve considerable errors, which motivated us to develop alternative means for estimating the CME mass. Aims. We aim at further developing and testing a method that allows estimating the mass of CMEs that propagate approximately along the observer's line of sight. Methods. We analyzed the temporal evolution of the mass of 32 white-light CMEs propagating across heliocentric heights of 2.5-15 R, in combination with that of the mass evacuated from the associated low coronal dimming regions. The mass of the white-light CMEs was determined through existing methods, while the mass evacuated by each CME in the low corona was estimated using a recently developed technique that analyzes the dimming in extreme-UV (EUV) images. The combined white-light and EUV analyses allow the quantification of an empirical function that describes the evolution of CME mass with height. Results. The analysis of 32 events yielded reliable estimates of the masses of front-side CMEs. We quantified the success of the method by calculating the relative error with respect to the mass of CMEs determined from white-light STEREO data, where the CMEs propagate close to the plane of sky. The median for the relative error in absolute values is ≈30%; 75% of the events in our sample have an absolute relative error smaller than 51%. The sources of uncertainty include the lack of knowledge of piled-up material, subsequent additional mass supply from the dimming region, and limitations in the mass-loss estimation from EUV data. The proposed method does not rely on assumptions of CME size or distance to the observer's plane of sky and is solely based on the determination of the mass that is evacuated in the low corona. It therefore represents a valuable tool for estimating the mass of Earth-directed events.Fil: López, F. M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Cremades Fernandez, Maria Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Tecnológica Nacional; ArgentinaFil: Balmaceda, Laura Antonia. George Mason University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Nuevo, Federico Alberto. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Vásquez, A. M.. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; Argentina. Universidad Nacional de Tres de Febrero; Argentin

Training habits, motivation, quality of life and sport injuries in 12 to 15 years old basketball players

Background: Previous studies of basketball injury have not been able to compare injury incidence and risk with their healthy habits. Purpose: To determine rates and risks of injury in Spanish boys and girls basketball players. Study Type: Descriptive epidemiology study. Methods: A survey was carried out on injuries produced in basketball players during the seasons 2006-07, 2007-08 and 2008-09, which included their type, incidence and treatment. There took part 217 players - 12 to years old -. They were given a questionnaire related to habits and sports injuries and the SF-36 v2 Health Questionnaire. Results: The injuries took place both while competition and training, being ankle sprain the most frequent injury in both cases. After ankle sprain; the prevailing injuries were sprain - luxation of the fingers and knee sprain. Most of the players who got injured were the base, the forward, and the guard. A 53 % had suffered some injury in the last three seasons, being falling off the most frequent cause. The incidence of injuries out of every 1000 hours of exhibition found in the study is 1.39. There have been found significant differences in the exposure to injuries at the outcome of skill circuits at Interval Training work during training hours. The mental component is an important factor to be considered in all caused injuries

Effect of conductivity and frequency on detection of heterogeneities in solid/liquid interfaces using local electrochemical impedance Theoretical and experimental study

This short communication demonstrates, by solving the Laplace equation with proper boundary conditions (BC) using finite element method (FEM), that it is not possible to establish a correlation between what happens in the electrolyte near an active boundary and what really occurs at the actual boundary if adequate ranges of electrolyte conductivity and input AC signal frequency are not selected, especially when inhomogeneities approximated by Neumann BC are present. Experimental evidence obtained by local electrochemical impedance mapping (LEIM) supports the theoretical results.This work has been supported by the Ministry of Science and Inno-vationofSpain(MAT2006-04486andIPT-020000-2010-0001Projects

The economics of carbon leakage mitigation policies

Carbon leakage occurs when carbon-priced low-emission domestic products are replaced with high-emissions foreign products. In a trade model with endogenous emissions abatement, we investigate the impact of three policies aimed at mitigating carbon leakage: free emission allowances, Carbon Border Adjustment Mechanism (CBAM) and export rebates. Providing allowances for free does not alter the incentives to abate carbon emissions, but fosters the entry of more carbon intensive producers. It levels the “playing field” both domestically and internationally, and may even reverse the carbon leakage. In contrast, the CBAM levels the playing field only domestically, which may lead to an autarky equilibrium. To reverse the carbon leakage, the CBAM should be complemented with other policies, such as export rebates. The optimality of these policies depends on the geographical scope of carbon emissions. With trade-adjusted emissions, the CBAM is always welfare enhancing, while free allowances alone are not. We then formally characterize the optimal combination of the three policies. Lastly, we calibrate the model to simulate the effects of the CBAM recently proposed by the European Union. The policy, when accompanied with either free allowances or export rebates, reverses the carbon leakage in the cement and steel sectors, and increases welfare in almost all sectors

Complufoto 2. Creación de un censo guía de fondos y colecciones fotográficas de la UCM y de un banco de imágenes para su aplicación en la docencia y en la investigacion

Censo guía de colecciones fotográficas de la UCM que permita la recuperación de fotografías para su aplicación en la docencia, tanto en actividades fotográficas como en otras a las que sea aplicable la fotografía. Se han recopilad los fondos y colecciones de instituciones de relevancia, tales como la Biblioteca Histórica Marqués de Valdecilla de la UCM y la Facultad de Bellas Artes

Electrophysiological evidence of sustained spatial attention effects over anterior cortex:Possible contribution of the anterior insula

Spatial attention can improve performance in terms of speed and accuracy; this advantage may be mediated by brain processes at both poststimulus (reactive) and prestimulus (proactive) stages. Here, we studied how visuospatial attention affects both proactive and reactive brain functions using event-related potentials (ERPs). At reactive stage, effects of attention on parietal-occipital components are well documented; little data are available on anterior components. Seventeen participants performed simple and discriminative response tasks, while voluntarily and steadily attending either the left or right visual hemifield throughout one block. Response speed was faster for the attended side. At ERP level, attending to one hemifield did not produce lateralization of proactive components—that is, the BP and the pN. As for poststimulus components, we confirmed the well-known amplitude effects on the P1, N1, and P3. More interesting are results for the prefrontal components previously neglected in tasks modulating spatial attention. Previous studies suggest that these components reflect perceptual and sensory-motor awareness (pN1 and pP1 components), and stimulus-response mapping (pP2 component) associated to anterior insular activity. Spatial attention enhanced the pN1 and the pP1 amplitude but had no effect on the pP2. Overall, results extend knowledge on spatial attention, showing that sustained spatial attention affects the activity of anterior areas, such as the anterior insula, in addition to the known influence on occipital-parietal areas. Top-down spatial attention is likely mediated by increased sensory and sensory-motor awareness for attended events; this effect is evident in reactive, not proactive, brain activity.</p

14q13 distal microdeletion encompassing NKX2-1 and PAX9: Patient report and refinement of the associated phenotype

Chromosome 14q11-q22 deletion syndrome (OMIM 613457) is a rare genomic disorder whose associated phenotype is heterogeneous, depending on the size, and, mostly, on the deleted region. We report the clinical and molecular characterization of a female newborn, whose phenotype was characterized by poor growth, dysmorphic facial features, subclinical hypothyroidism, and mild reduction of CD3CD8 Lymphocytes with increased CD4/CD8 ratio. By array-CGH, we identified a 4.08 de novo interstitial deletion of the 14q13.2q21.1 region, which includes 16 OMIM genes.Our patient phenotype is compared with other published cases, for a better classification of the 14q11-q22 deletion syndrome. We demonstrated that the 14q13.2q21.1 deletion, which encompasses NKX2-1, but not FOXG1 gene and HPE8 region, identifies a well defined, more benign, microdeletion syndrome. This report confirms that an early identification with accurate characterization of the genomic disorders is of great relevance, enabling proper genetic counseling of the reproductive risk, as well as disease prognosis, and patient management. © 2016 Wiley Periodicals, Inc

Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of HLA Class I Alterations in Cancer

Total or partial loss of HLA class I antigens reduce the recognition of specific tumor peptides by cytotoxic T lymphocytes favoring cancer immune escape during natural tumor evolution. These alterations can be caused by genomic defects, such as loss of heterozygosity at chromosomes 6 and 15 (LOH-6 and LOH-15), where HLA class I genes are located. There is growing evidence indicating that LOH in HLA contributes to the immune selection of HLA loss variants and influences the resistance to immunotherapy. Nevertheless, the incidence and the mechanism of this chromosomal aberration involving HLA genes has not been systematically assessed in different types of tumors and often remains underestimated. Here, we used SNP arrays to investigate the incidence and patterns of LOH-6 and LOH-15 in a number of human cancer cell lines and tissues of different histological types. We observed that LOH in HLA is a common event in cancer samples with a prevalence of a copy neutral type of LOH (CN-LOH) that affects entire chromosome 6 or 15 and involves chromosomal duplications. LOH-6 was observed more often and was associated with homozygous HLA genotype and partial HLA loss of expression. We also discuss the immunologic and clinical implications of LOH in HLA on tumor clonal expansion and association with the cancer recurrence after treatment.ISCIII Research Institute co-financed by the European Union and Ministerio de Ciencia e Innovación (FEDER-Fondo Europeo de Desarrollo Regional and National Plan 2020, MICIN) (PI17/00197, PI18/00826, and PID2020-115087GB-100)Junta de Andalucía in Spain (Group CTS-143 and B-CTS-410-UGR-20)Consejería de Salud, Junta de Andalucía through the contract “Nicolás Monardes” [C-0013-2018

Acciaio per l'industrializzazione : contributi allo studio del problema siderurgico italiano

Fondazione Luigi Einaudi Studi 1- Indice #7- Premessa #9- I perché di una «mezza siderurgia». La società Ilva, l'industria della ghisa e il ciclo integrale negli anni Venti #21-L'industria padana dell'acciaio nel primo trentennio del Novecento #177- La riforma siderurgica Iri tra autarchia e mercato (1935-42) #233- I gruppi dirigenti della siderurgia «pubblica» tra gli anni Trenta e gli anni Sessanta #353- La domanda siderurgica italiana negli anni Trenta #38