21 research outputs found
Diels-Alder reactions of Ni(II) β-vinyl-meso-tetraarylporphyrins
The cycloaddition reactions of nickel(II) β-vinyl-meso-tetraphenylporphyrins with tetracyanoethylene (TCNE) in chloroform, afford [2+2] adducts containing a cyclobutane ring and [4+2] adducts. The [2+2] adducts can also be produced by rearrangement of the [4+2] chlorins
New naphthochlorins from the intramolecular cyclization of β-vinyl-meso-tetraarylporphyrins
Treatment of nickel(II) β-vinyl-meso-tetraphenylporphyrins with a dilute solution of sulfuric acid affords new naphthochlorins that result from an intramolecular cyclization involving the vinyl group and the ortho position of the adjacent phenyl ring. These naphthochlorins are very stable compounds and exhibit strong absorptions in the 670 nm region of the visible spectrum. © 1995
Meso-Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy
Studies on the synthesis, preliminary in vivo biological activity, singlet oxygen and fluorescence yields of a climeric porphyrin (D1) are described. The pharmacokinetic behavior and photodynamic properties of the dimer D1 were examined in Balb/c mice bearing an MS-2 fibrosarcoma. Compound D1 shows a high selectivity for tumor localization (tumor/peritumoral tissue ratios of dye concentration ranging between ca 100 and 140 at 24 h after drug administration of 5.0-1.0 mg kg-1 into DL-α-dipalmitoylphosphatidylcholine liposomes). The phototherapeutic efficiency of dimer D1 was evaluated by following the growth curves of fibrosarcoma irradiated with red light (600-700 nm) with a total dose of 400 J cm-2, at 24 h after intravenous injection. Photodynamic therapy-treated tumors showed a significant delay in growth as compared to untreated control mice. The results obtained suggest that the porphyrin dimer D1 may be a promising candidate for further use in PDT experiments
A facile and effective synthesis of 4-imino-3-(arylidene)- azetidine-2-thiones via phosphorus pentasulfide
<div><p>A new and an efficient synthesis of 4-imino-3-(arylidene)-azetidine-2-thiones is reported. The reaction of arylidenemalononitriles with phosphorus pentasulfide and ethanol affords the title products in good yields. Elemental analysis, infrared, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectral data elucidated structure of newly synthesized compounds.</p></div
A facile and effective synthesis of 4-imino-3-(arylidene)- azetidine-2-thiones via phosphorus pentasulfide
Evaluation of meso-substituted cationic corroles as potential antibacterial agents
ABSTRACT Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III)pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain
Evaluation of meso-substituted cationic corroles as potential antibacterial agents
<div><p>ABSTRACT Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III)pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.</p></div