Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil

Optimal sedation and analgesia are of key importance in intensive care. The aim of this study was to assess the quality of sedoanalgesia and outcome parameters in regimens containing midazolam and either fentanyl or remifentanil. A prospective, randomized, open-label, controlled trial was carried out in the ICU unit of a large teaching hospital in Istanbul over a 9-month period. Thirty-four patients were randomly allocated to receive either a remifentanil-midazolam regimen (R group, n = 17) or a fentanyl-midazolam regimen (F group, n = 17). A strong correlation between Riker Sedation-Agitation Scale (SAS) and Ramsey Scale (RS) measurements was observed. Comparatively, remifentanil provided significantly more potent and rapid analgesia based on Behavioral-Physiological Scale (BPS) measurements and a statistically nonsignificantly shorter time to discharge. On the other hand, remifentanil also caused a significantly sharper fall in heart rate within the first six hours of treatment

Effect of Government Expenditure on GDP in the Turkish Economy

The objective of this article is to investigate the effect of government expenditure on GDP in Turkey from 2000Q1-2015Q4 by the superexogeneity test. As a consequence of satisfying both conditions of weak exogeneity and structural invariance, government expenditure is super exogenous to GDP which implies that the policy regime shift for the period of the Global Financial Crisis in Turkey did not cause structural variance in government expenditure. Indeed, the Lucas Critique which indicates that policy regime shifts cause structural breaks, appears to be refuted

Bis[N-(2,6-Dimethylphenyl)Amino-Glyoximato-N,N']Nickel(II)

The title compound consists of discrete centrosymmetric [Ni(C10H12N3O2)(2)] molecules. The coordination around the Ni atom is square planar, involving four oxime N atoms of two chelating C2H2N2O2 groups. The oxime O atoms are linked by an intramolecular hydrogen bond [O ... O 2.546 (2) Angstrom] The Ni-N distances are 1.891 (2) and 1.846 (2) Angstrom, and the N-Ni-N angle within the NiC2N2 chelate ring is 82.75 (8)degrees. In the central portion of the molecule, the C=N distances are equal [1.297(3) and 1.298(3) Angstrom], while the two N-O distances are different [1.303 (3) and 1.386 (3) Angstrom].WoSScopu

Evaluation of three cases of mycotic keratitis caused by Fusarium solani sensu stricto (FSSC5)

WOS: 000434852700526

Mycotic Keratitis Caused by Fusarium solani sensu stricto (FSSC5) : A Case Series

Owing to a lack of appropriate diagnostic and therapeutic approaches for mycotic keratitis, approximately one million cases of preventable corneal blindness are reported each year. The number of keratitis cases due to infection with Fusarium is increasing significantly worldwide, many of which are not treated adequately and in a timely manner due to frequent misdiagnosis. In the current report, we describe three cases of keratitis caused by Fusarium solani sensu stricto (FSSC5) from Turkey and The Netherlands, following ocular trauma. The etiological agent of keratitis, FSSC5, identified by sequencing of the partial tef1-α gene, exhibited low minimum inhibitory concentrations (MICs) of 1 µg/mL for amphotericin B and high MICs above the published epidemiological cutoff values for voriconazole (8 µg/mL). Patients were successfully treated with topical amphotericin B and voriconazole with complete recovery.</p