Indicators for the Circular City: A Review and a Proposal

The theme of the circular city is currently much debated in the literature as a possible strategy for achieving sustainability in urban areas. However, as a recent development it still has many features in the making, one of the most important being the issue concerning monitoring and the tool through which to achieve it. In the paper, therefore, the “indicator” tool is explored in depth. Metrics represent a fundamental and complex aspect that is foundational to measuring and quantifying the progress of results achieved with respect to the goals set. Currently, most existing indicators are associated with specific aspects of the circular economy; there have been few examples of indicators designed to assess the circularity of an entire city. The paper aims to identify priority themes and describe a set of indicators to be used at the urban level. In the absence of an established reference frame, themes and indicators were identified through a methodology starting with an extensive literature search and careful analysis, including statistical analysis, of the scientific literature as well as international and European strategies on the subject. A particular result of this research is the definition ofa minimum set of indicators common to all cities, which can be applied for comparative purposes

Intuitionistic logic as a connexive logic

We show that intuitionistic logic is deductively equivalent to Connexive Heyting Logic (CHL), hereby introduced as an example of a strongly connexive logic with an intuitive semantics. We use the reverse algebraisation paradigm: CHL is presented as the assertional logic of a point regular variety (whose structure theory is examined in detail) that turns out to be term equivalent to the variety of Heyting algebras. We provide Hilbert-style and Gentzen-style proof systems for CHL ; moreover, we suggest a possible computational interpretation of its connexive conditional, and we revisit Kapsner’s idea of superconnexivity

Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment

The aim of this study was to investigate sperm DNA damage induced by chemo- and radiotherapy in patients with testicular cancer to provide data on the extent and persistence of nuclear damage that might affect individual reproductive potential. We evaluated pre- and post-antineoplastic treatment sperm DNA integrity, expressed as DNA Fragmentation Index (DFI), in a large caseload of testicular cancer patients by sperm chromatin structure assay. The mean total DFI for all patients at T0 was 18.0 ± 12.5%. Sperm chromatin profile was markedly impaired at T3 (27.7 ± 17.4%) and T6 (23.2 ± 15.3%), improving considerably at T12 and T24 (14.0 ± 8.9% and 14.4 ± 10.3%). After chemotherapy, we found a marked increase in DFI at T3 and T6 and a significant reduction at T12 and T24 in comparison with the baseline. In contrast, DFI increased at T3 and T6 after radiotherapy but the subsequent reduction was far less marked, reaching baseline values at T12 and T24. Finally, post-treatment DNA damage was not age or histotype dependent, but was more marked in the advanced stage of cancer. In this study, we showed that the chromatin profile may be affected in the months immediately following the end of the treatment, improving after 12-24 months. Our results thus indicate that post-treatment DNA damage is influenced both by the type and intensity of the therapy and by the pathological and clinical stage of the disease. © 2014 American Society of Andrology and European Academy of Andrology

Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk

PURPOSE: We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). METHODS: We evaluated 125 TC patients and 103 controls. Seminal fluid examination and organochlorine analysis were performed in all subjects. Cases and controls were also interviewed using a structured questionnaire to collect demographic information, residence, andrological medical history and dietary information. RESULTS: We found that a higher level of reproductive tract birth defects was associated with a higher risk of TC. With regard to diet, cases reported a higher consumption of milk and dairy products than controls. Overall, there was a statistically significant increase in TC risk in cases with detectable values of total polychlorinated organic compounds against controls (14.4 vs. 1.0 %; p < 0.001). TC patients with detectable levels of organochlorines had lower mean semen parameters than those with undetectable levels, although this difference was not statistically significant. CONCLUSION: The International Agency for Research on Cancer recently included dioxin-like polychlorinated biphenyls (PCBs) in Group 1 of known human carcinogens. Our study confirmed and identified various risk factors for testicular cancer: cryptorchidism, consumption of milk and dairy products, parents' occupation and serum concentration of hexachlorobenzene and PCBs and, for the first time, we showed the correlation between semen quality and the serum concentration of these pollutants

Androgen receptor polymorphisms and testicular cancer risk

Testicular cancer (TC) is currently the most common malignant solid tumour in Caucasian males aged 15-39 years. Epidemiological evidence suggests that its onset may be due to an imbalance in the action of steroidal sex hormones and their receptors. A faulty androgen receptor signalling pathway can, in fact, cause various male reproductive disorders. The androgen receptor (AR) gene has two polymorphic segments consisting of CAG and GGC repeats. The length of CAG repeats has been shown to affect the regulation of AR activity. In our study, we used fragment analysis to evaluate the AR gene repeats of 302 TC patients and 322 controls, to establish if there is any association between repeat number and TC. This study of the largest Italian caseload investigated to date highlighted three particularly significant aspects. First, a CAG repeat number of ≥25 may be considered a risk factor for the onset of TC, given its greater frequency in patients in comparison with controls. This difference became significant for the non-seminoma group. Second, men with CAG repeats below 21 or above 24 were found to have a, respectively, 50 and 76% higher risk of TC than those with CAG 21-24, suggesting that these too can be considered a risk factor for TC. Finally, stage II patients were more likely to have a CAG repeat number 24 than stage I patients. © 2014 American Society of Andrology and European Academy of Andrology

Towards the ultimate regime in Rayleigh-Darcy convection

Numerical simulations are used to probe Rayleigh-Darcy convection in fluid-saturated porous media towards the ultimate regime. The present three-dimensional dataset, up to Rayleigh-Darcy number, suggests that the appropriate scaling of the Nusselt number is, fitting the computed data for. Extrapolation of current predictions to the ultimate linear regime yields the asymptotic law, about less than indicated in previous studies. Upon examination of the flow structures near the boundaries, we confirm previous indications of small flow cells hierarchically nesting into supercells, and we show evidence that the supercells at the boundary are the footprints of the megaplumes that dominate the interior part of the flow. The present findings pave the way for more accurate modelling of geophysical systems, with special reference to geological sequestration