Model Pengembangan Kompetensi Profesional Guru Fisika Kota Semarang Pasca Sertifikasi Melalui Mgmp

Pengakuan kinerja profesi dalam bentuk sertifikat pendidik tidaksaja memvonis seorang guru mumpuni diatas segalanya, tetapi jugamembuat arogansi tersendiri. Pengakuan sebagai agen pembelajaranyang profesional memang hanya bergantung pada selembarpenghargaan sertifikat pendidik.Permusan masalah penelitian ini adalah bagaimanakahdeskripsi pengembangan kompetensi profesional guru fisika pascasertifikasi di kota Semarang ? Bagaimanakah model pengembanganguru fisika pasca sertifikasi di kota Semarang ? Tujuan yang akandicapai pada penelitian ini adalah mengetahui gambaranpengembangan kompetensi profesional guru fisika pasca sertifikasi dikota Semarang.Model pengembangan guru pasca sertifikasi dilakukan denganmenggunakan model Jigsaw yang tergambar dalam skema kegiatanMGMP, dilengkapi dengan sintaks, alokasi waktu dan monitoringserta pengawasan. Uji ahli dan praktisi sebanyak 6 orang. 1 orangmenyatakan model berada dalam kriteria sangat baik (1 orang daritim ahli), 4 orang menyatakan baik (1 tim ahli , 3 praktisi), dan 1orang dari tim praktisi menyatakan cukup. Berdasarkan uji ahli danpraktisi tersebut maka model ini dapat diimnplementasikan dalamkegiatan MGMP. Oleh karena keterbatasan waktu dan biaya maka ujicoba dan implementasi tidak dapat dilaksanakan.?é?

Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review

Melastoma malabathricum L. (Melastomataceae) is one of the 22 species found in the Southeast Asian region, including Malaysia. Considered as native to tropical and temperate Asia and the Pacific Islands, this commonly found small shrub has gained herbal status in the Malay folklore belief as well as the Indian, Chinese, and Indonesian folk medicines. Ethnopharmacologically, the leaves, shoots, barks, seeds, and roots of M. malabathricum have been used to treat diarrhoea, dysentery, hemorrhoids, cuts and wounds, toothache, and stomachache. Scientific findings also revealed the wide pharmacological actions of various parts of M. malabthricum, such as antinociceptive, anti-inflammatory, wound healing, antidiarrheal, cytotoxic, and antioxidant activities. Various types of phytochemical constituents have also been isolated and identifed from different parts of M. malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents, and pharmacological activities of M. malabathricum

The antimicrobial properties of nanotitania extract and its role in inhibiting the growth of klebsiella pneumonia and haemophilus influenza

Titanium dioxide (TiO2) is an antimicrobial agent which is considered of potential value in inhibiting the growth of multiple bacteria. Klebsiella pneumonia and Haemophilus influenza are two of the most common respiratory infection pathogens, and are the most. Klebsiella pneumonia causes fatal meningitis, while Haemophilus influenza causes mortality even in younger patients. Both are associated with bacteremia and mortality. The purpose of this study was to test a new antibacterial material, namely nanotitania extract combined with 0.03% silver that was developed at Universiti Malaysia Sabah (UMS) and tested against K. pneumonia and H. influenza. The nanoparticles were synthesized through a modified hydrothermal process, combined with molten salt and proven to have excellent crystallinity, with the band-gap energy falling in the visible light spectrum. The nanoparticle extract was tested using a macro-dilutional method, which involved combining it with 0.03% silver solution during the process of nanoparticle synthesis and then introducing it to the bacteria. A positive control containing the bacteria minus the nanoparticles extract was also prepared. 25 mg/mL, 12.5 mg/mL, and 6.25 mg/mL concentrations of the samples were produced using the macro dilution method. After adding the bacteria to multiple concentrations of nanoparticle extract, the suspensions were incubated for 24 h at a temperature of 37 °C. The suspensions were then spread on Mueller-Hinton agar (K. pneumonia) and chocolate blood agar (H. influenza), where the growth of bacteria was observed after 24 h. Nanoparticle extract in combination with silver at 0.03% was proven to have potential as an antimicrobial agent as it was able to inhibit H. influenza at all concentrations. Furthermore, it was also shown to be capable of inhibiting K. pneumonia at concentrations of 25 mg/mL and 50 mg/mL. In conclusion, the nanoparticle extract, when tested using a macro-dilutional method, displayed antimicrobial properties which were proven effective against the growth of both K. pneumonia and H. influenza

Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis

The T-cell receptor (TCR) is a highly polymorphic surface receptor that allows T-cells to recognize antigenic peptides presented on the major histocompatibility complex (MHC). Changes in the TCR repertoire have been observed in several autoimmune conditions, and these changes are suggested to predispose autoimmunity. Multiple lines of evidence have implied an important role for T-cells in the pathogenesis of Systemic Sclerosis (SSc), a complex autoimmune disease. One of the major questions regarding the roles of T-cells is whether expansion and activation of T-cells observed in the diseases pathogenesis is antigen driven. To investigate the temporal TCR repertoire dynamics in SSc, we performed high-throughput sequencing of CD4+ and CD8+ TCRβ chains on longitudinal samples obtained from four SSc patients collected over a minimum of two years. Repertoire overlap analysis revealed that samples taken from the same individual over time shared a high number of TCRβ sequences, indicating a clear temporal persistence of the TCRβ repertoire in CD4+ as well as CD8+ T-cells. Moreover, the TCRβs that were found with a high frequency at one time point were also found with a high frequency at the other time points (even after almost four years), showing that frequencies of dominant TCRβs are largely consistent over time. We also show that TCRβ generation probability and observed TCR frequency are not related in SSc samples, showing that clonal expansion and persistence of TCRβs is caused by antigenic selection rather than convergent recombination. Moreover, we demonstrate that TCRβ diversity is lower in CD4+ and CD8+ T-cells from SSc patients compared with memory T-cells from healthy individuals, as SSc TCRβ repertoires are largely dominated by clonally expanded persistent TCRβ sequences. Lastly, using “Grouping of Lymphocyte Interactions by Paratope Hotspots” (GLIPH2), we identify clusters of TCRβ sequences with homologous sequences that potentially recognize the same antigens and contain TCRβs that are persist in SSc patients. In conclusion, our results show that CD4+ and CD8+ T-cells are highly persistent in SSc patients over time, and this persistence is likely a result from antigenic selection. Moreover, persistent TCRs form high similarity clusters with other (non-)persistent sequences that potentially recognize the same epitopes. These data provide evidence for an antigen driven expansion of CD4+/CD8+ T-cells in SSc

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council

The role of host genetic factors in respiratory tract infectious diseases:systematic review, meta-analyses and field synopsis

Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29-2.14]). We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03-5.02]). Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72-0.88]). The IL4-TLR2-CCL2 axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidenc

Let’s collaborate’: Malaysian TVET-engineering institution and industry partnership

Strategic partnerships are the most important element in the automotive industry. The interaction between two or more parties is important in pursuing the successful planning and implementation of an education and training system in producing a competent workforce. Malaysia is one country that has adopted Public Private Partnership (PPP) as a procurement technique for delivering public sector projects. PPP, taken in its broadest meaning, refers to any arrangement between the public and private sectors for the delivery of public services. However, previous studies indicated that the collaboration between training institutions and industry is still at a weak level. The major constraints were including the failure to understand the work culture of the organization, inconsistency of mission and vision of the organization, weaknesses of the governance system. Therefore, this study aims to propose a model of TVET-Engineering Governance Structure in Collaboration of Malaysian TVET-Engineering Institution and industry partnership. In this case, data were collected from 115 technologists in three different fields involved mechanical, electric and electronic and civil in Malaysia. Then, the data were analysed using the PLS-SEM 3.3.9 software via the algorithm, bootstrapping and blindfolding method. Through the PLS-SEM approach, this study focuses on the analysis of (a) convergent validity and (b) discriminant validity in which these two validities have six analyses; (i) external loading, (ii) composite reliability, (iii) average variance extracted (AVE), (iv) Fornell-Larcker, (v) cross-loading, and (vi) Heterotrait-Monotrait Ratio (HTMT). Meanwhile, the structural model testing involves the analysis of (i) Multicollinearity (Inner VIF), (ii) Path Coefficient, (iii) R square (R2), (iv) size effect (f2), and (v) Predictive Relevance (Q2). At the end of the analysis, the model that has been developed is relevant to use because each phase meets the conditions that have been set in the PLS-SEM analysis. The result, the governance structure for TVET-Engineering for TVET-Engineering is important since it can contribute to intensifying the Malaysian TVET- Engineering Institution and industry partnership. TVET Institutions must play an important role in fulfilling the demands from the industry and developing innovative skills for students. Future research is suggested to test the model on a wider range of TVET respondents to see its appropriateness

Implementasi Sistem Kontrol Berbasis Web Pada Smart Room Dengan Menggunakan Konsep Internet of Things

Saat ini sistem yang dapat mengontrol suatu ruangan secara otomatis masih sangat hangat dan digemari masyarakat modern melihat fungsinya yang sangat berkesesuaian dengan fungsi utama dari teknologi itu sendiri yaitu mempermudah serta membantu kebutuhan manusia. Agar kondisi rumah bisa di kontrol jarak jauh tentunya banyak teknologi-teknologi yang harus diterapakan seperti pemasangan sensor agar bisa mendeteksi secara otomatis bila terjadi pemasalahan dan juga biasanya ada juga alat kontrol berupa mikro kontroler yang bertujuan untuk mengontrol peralatan elektronik yang dipadukan dengan konsep internet of things. Internet of Things sendiri merupakan sebuah konsep yang bertujuan untuk memperluas manfaat dari konektivitas internet yang tersambung secara terus menerus. Adapun kemampuan seperti berbagi data, remote control dan sebagainya, termasuk juga pada benda di dunia nyata. Contohnya peralatan elektronik yang terhubung ke jaringan lokal dan global melalui sensor yang tertanan dan selalu aktif. Dengan melihat definisi dari ini Internet of Things ini sangat cocok untuk diterapkan pada konsep smart room

Preliminary Analysis Kesulitan Mahasiswa S-1 Pgsd dalam Mereview Artikel Ilmiah di Jurnal

Reviewing scientific articles published in journals is a competency needed by students to improve their writing skills. As a form of implementation of Higher Education Tri Dharma in the field of education, lecturers are responsible for training students to review articles. To provide optimal learning facilities, information is needed related to student difficulties in reviewing articles in journals. This study aims to diagnose the difficulties of undergraduate students at PGSD FKIP Mataram University in reviewing scientific articles in journals. The study was conducted on S1 students of PGSD FKIP Mataram University who programed Quantitative Research Methods courses. The research subject of 36 students was determined using a purposive sampling technique. Data collection is done by assigning students to review 1 scientific article published by a SINTA accredited journal. The results of the review by students were analyzed descriptively to determine the location of student difficulties. The results showed that the largest proportion of student difficulties lies in the research method (86.11%), then the research problem (44.44%), and the smallest proportion is the research result (5.56%). Information from the results of this study can be used as a reference for providing learning facilities to improve student review skills. This skill can help students in completing theses which have been a problem for many undergraduate students at PGSD FKIP Mataram University