Escape from the List: Courage, Sacrifice, Survival

Anne Frank has been described as Hitler’s most famous victim. By virtue of her diary, which was in fact a heavily revised memoir that today might be considered to belong to the genre of creative non-fiction, Anne Frank has attained a kind of immortality that the art form of writing frequently provides. This should not, of course, trivialize her fate, nor the suffering of the multitudes of other victims of the Nazi regime, a group comprised of Jews, as well as non-Jews. Some of these stories have been told in great detail, while many others have not. What follows is the story of Elisabeth Rodrigues Lopes de la Peña, a Jewish girl whose family had fled the Spanish Inquisition to settle in the Netherlands. During the German occupation of Amsterdam during the Second World War, this family faced yet another existential threat, one that some of them did not survive. Elisabeth may well have ended up as yet one more entry in the long list of the Nazi’s victims, if not for the intervention and courageous efforts of her non-Jewish neighbors—efforts that were based in large part on their own deeply held religious beliefs and sense of morals. Elisabeth’s rescuers are known to Holocaust historians, and their names are enshrined in the Yad Vashem World Holocaust Remembrance Museum in Israel, as well as in the United States Holocaust Memorial Museum in Washington, DC. Along with my Research Assistant Angelica Roman, I have conducted personal meetings and interviews with Elisabeth’s daughter, Carolyn Stewart. Ms. Stewart has graciously shared many heretofore unknown details of her mother’s story of rescue, as well as photographs and documents, including some that have been unseen by anyone in over sixty years. What follows is new insight into Elisabeth Rodrigues’ escape from the list: a true story of courage, sacrifice, and survival. I would like to acknowledge with gratitude the assistance and support of the following people: Jennifer Crespo, Student Success Coordinator at Pace University in New York City, who generously provided funding for this project as part of the Pace Undergraduate Student – Faculty Research Program; Bonnie and Howard J. Price, without whose help this project would never have seen the light of day; my colleague at Pace University Dr. Maria Plochocki, for reviewing the manuscript and providing valuable suggestions; Gertjan Broek and Karolien Stocking Korzen at the Anne Frank House in Amsterdam; Beth Slepian at The Anne Frank Center NYC, and my superbly talented Research Assistant, Angelica E. Roman ‘19, who tirelessly conducted research, helped revise early drafts, and patiently fielded a multitude of my requests while putting up with my numerous anxieties. Special thanks go to Carolyn Stewart, who traveled from Maryland to New York City for interviews, and who spent many hours communicating with Angelica and me over the course of several months. Carolyn shared many details and primary historical artifacts with us, and she relates her mother’s fascinating tale in a captivating and compelling manner. Our hope is that we can do this wonderful, inspiring story justice in the pages that follow

Simulated Thrombin Generation in the Presence of Surface-Bound Heparin and Circulating Tissue Factor

An expanded computational model of surface induced thrombin generation was developed that includes hemodynamic effects, 22 biochemical reactions and 44 distinct chemical species. Surface binding of factors V, VIII, IX, and X was included in order to more accurately simulate the formation of the surface complexes tenase and prothrombinase. In order to model these reactions, the non-activated, activated and inactivated forms were all considered. This model was used to investigate the impact of surface bound heparin on thrombin generation with and without the additive effects of thrombomodulin (TM). In total, 104 heparin/TM pairings were evaluated (52 under venous conditions, 52 under arterial conditions), the results demonstrating the synergistic ability of heparin and TM to reduce thrombin generation. Additionally, the role of circulating tissue factor (TF[subscript p]) was investigated and compared to that of surface-bound tissue factor (TF[subscript s]). The numerical results suggest that circulating TF has the power to amplify thrombin generation once the coagulation cascade is already initiated by surface-bound TF. TF[subscript p] concentrations as low as 0.01 nM were found to have a significant impact on total thrombin generation.National Institutes of Health (U.S.) (Grants HL106018 and HL56819

De-biased Populations of Kuiper Belt Objects from the Deep Ecliptic Survey

The Deep Ecliptic Survey (DES) discovered hundreds of Kuiper Belt objects from 1998-2005. Follow-up observations yielded 304 objects with good dynamical classifications (Classical, Scattered, Centaur, or 16 mean-motion resonances with Neptune). The DES search fields are well documented, enabling us to calculate the probability of detecting objects with particular orbital parameters and absolute magnitudes at a randomized point in each orbit. Grouping objects together by dynamical class leads, we estimate the orbital element distributions (a, e, i) for the largest three classes (Classical, 3:2, and Scattered) using maximum likelihood. Using H-magnitude as a proxy for the object size, we fit a power law to the number of objects for 8 classes with at least 5 detected members (246 objects). The best Classical slope is alpha=1.02+/-0.01 (observed from 5<=H<=7.2). Six dynamical classes (Scattered plus 5 resonances) are consistent in slope with the Classicals, though the absolute number of objects is scaled. The exception to the power law relation are the Centaurs (non-resonant with perihelia closer than Neptune, and thus detectable at smaller sizes), with alpha=0.42+/-0.02 (7.5<H<11). This is consistent with a knee in the H-distribution around H=7.2 as reported elsewhere (Bernstein et al. 2004, Fraser et al. 2014). Based on the Classical-derived magnitude distribution, the total number of objects (H<=7) in each class are: Classical (2100+/-300 objects), Scattered (2800+/-400), 3:2 (570+/-80), 2:1 (400+/-50), 5:2 (270+/-40), 7:4 (69+/-9), 5:3 (60+/-8). The independent estimate for the number of Centaurs in the same H range is 13+/-5. If instead all objects are divided by inclination into "Hot" and "Cold" populations, following Fraser et al. (2014), we find that alphaHot=0.90+/-0.02, while alphaCold=1.32+/-0.02, in good agreement with that work.Comment: 26 pages emulateapj, 6 figures, 5 tables, accepted by A

A genetic and molecular model for flower development in Arabidopsis thaliana

Cells in developing organisms do not only differentiate, they differentiate in defined patterns. A striking example is the differentiation of flowers, which in most plant families consist of four types of organs: sepals, petals, stamens and carpels, each composed of characteristic cell types. In the families of flowering plants in which these organs occur, they are patterned with the sepals in the outermost whorl or whorls of the flower, with the petals next closest to the center, the stamens even closer to the center, and the carpels central. In each species of flowering plant the disposition and number (or range of numbers) of these organs is also specified, and the floral 'formula' is repeated in each of the flowers on each individual plant of the species. We do not know how cells in developing plants determine their position, and in response to this determination differentiate to the cell types appropriate for that position. While there have been a number of speculative proposals for the mechanism of organ specification in flowers (Goethe, 1790; Goebel, 1900; Heslop-Harrison, 1964; Green, 1988), recent genetic evidence is inconsistent with all of them, at least in the forms in which they were originally presented (Bowman et al. 1989; Meyerowitz et al. 1989). We describe here a preliminary model, based on experiments with Arabidopsis thaliana. The model is by and large consistent with existing evidence, and has predicted the results of a number of genetic and molecular experiments that have been recently performed

The Hubble Space Telescope high speed photometer

The Hubble Space Telescope will provide the opportunity to perform precise astronomical photometry above the disturbing effects of the atmosphere. The High Speed Photometer is designed to provide the observatory with a stable, precise photometer with wide dynamic range, broad wavelenth coverage, time resolution in the microsecond region, and polarimetric capability. Here, the scientific requirements for the instrument are examined, the unique design features of the photometer are explored, and the improvements to be expected over the performance of ground-based instruments are projected

Achievement goals, self-handicapping, and performance: A 2 × 2 achievement goal perspective

Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the work of Elliot et al. by experimentally promoting all four goals proposed by the 262 model (Elliot & McGregor, 2001), measuring the participants’ own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 262 model. The participants (n¼138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues’ findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on selfhandicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals

Mutations in human dynamin block an intermediate stage in coated vesicle formation

The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to block endocytosis at a stage after the initiation of coat assembly and preceding the sequestration of ligands into deeply invaginated coated pits. Membrane transport from the ER to the Golgi complex was unaffected indicating that dynamin mutants specifically block early events in endocytosis. These results demonstrate that mutations in the GTP-binding domain of dynamin block Tfn-endocytosis in mammalian cells and suggest that a functional dynamin GTPase is required for receptor-mediated endocytosis via clathrin-coated pits