Economic Impact of the Transportation Research Center Inc. on Central Ohio and the State Of Ohio

A recognized leader in transportation research and innovation since 1974, the Transportation Research Center Inc. (TRC), with its 4,500-acre testing facility and expert technical team, created more than $127 million total in economic output in 2019 and supported over 670 total jobs with almost$36 million in wages and benefits throughout Ohio, the study determined. Testing and research on behalf of TRC clients, including many of the world’s leading automotive manufacturers and systems innovators, generated more than $1.3 million in taxes to local government entities,$1.3 million to the state government and $2.3 million to the federal government. An additional$67.5 million in economic activity in the state was generated from 2011-2019 through multiple construction projects that expanded facilities on TRC’s campus

Connecting Cleveland: Economic Impact of Greater Cleveland Regional Transit Authority

The Center for Economic Development (the Center) produced this economic impact report for the Greater Cleveland Regional Transit Authority (GCRTA) to illustrate how their operations, infrastructure, and services contribute to Cuyahoga County’s economy. Cleveland is fortunate among the Midwestern metropolitan areas to have a rich transit history and infrastructure which is actively updated and shapes regional life. Among similar metro transit authorities in the region (Detroit, Cincinnati, and others), GCRTA was second only to Pittsburgh’s Port Authority of Allegheny County in terms of ridership and vehicle-revenue miles in 2017. With 2,300 full-time employees in 2017, GCRTA is the 13th largest Northeast Ohio employer based in Cleveland and the 38th largest in the region. GCRTA’s service area is Cuyahoga County; its 2017 operating budget totaled $247 million, and its capital budget varied from$60 million to $87 million over the last five years. The scale of GCRTA operations creates an economic impact on the regional economy and affects the lives of those who rely on its services to get to work, school, and local amenities. While its employees reside across Greater Cleveland, the lion\u27s share live in Cuyahoga County (82%). GCRTA spends roughly 24% of its operating budget and 30% of its capital expenditures within Cuyahoga County by purchasing from local suppliers. The direct employment and operations of GCRTA, their purchases from suppliers within Cuyahoga County, and local spending of GCRTA employees’ salaries and salaries of employees of local suppliers give a boost to the regional economy

Local Front Runners: GRIDs in the 4 Northeast Ohio Metropolitan Areas

Northeast Ohio (NEO) is an 18-county region which encompasses four different Metropolitan Statistical Areas (MSAs); MSAs commonly refer to the labor market of a given area (for this study: the Akron MSA, the Canton-Massillon MSA, the Cleveland-Elyria MSA, a part of the Youngstown-Warren-Boardman, OH-PA MSA) and remaining rural counties (“non-MSA counties”). Within NEO, these four distinct metro areas have different industry structures. Investigating the internal dynamics of each region’s economic driver industries—what we call Groups of Regional Industry Drivers (GRIDs)—can inform local leaders and economic development practitioners of expanding and emerging industries to foster regional growth. Economic trends in NEO over the past twenty years are typical of the Midwest region, with a positive increase in output outpaced by the state of Ohio and the United States. The two recessions of 2001 and 2009 showed deeper output declines across NEO than in comparable Midwest regions and the United States. The goal of this research is to provide up-to-date, data-driven insights for competitive industries in each of the four Northeast Ohio MSAs. This research seeks to update previous research conducted for the Regional Economic Competitiveness Strategy in 2011 and to provide understanding into the economies of each area

Local Front Runners: GRIDs in the 4 Northeast Ohio Metropolitan Areas

Northeast Ohio (NEO) is an 18-county region which encompasses four different Metropolitan Statistical Areas (MSAs); MSAs commonly refer to the labor market of a given area (for this study: the Akron MSA, the Canton-Massillon MSA, the Cleveland-Elyria MSA, a part of the Youngstown-Warren-Boardman, OH-PA MSA) and remaining rural counties (“non-MSA counties”). Within NEO, these four distinct metro areas have different industry structures. Investigating the internal dynamics of each region’s economic driver industries—what we call Groups of Regional Industry Drivers (GRIDs)—can inform local leaders and economic development practitioners of expanding and emerging industries to foster regional growth. Economic trends in NEO over the past twenty years are typical of the Midwest region, with a positive increase in output outpaced by the state of Ohio and the United States. The two recessions of 2001 and 2009 showed deeper output declines across NEO than in comparable Midwest regions and the United States. The goal of this research is to provide up-to-date, data-driven insights for competitive industries in each of the four Northeast Ohio MSAs. This research seeks to update previous research conducted for the Regional Economic Competitiveness Strategy in 2011 and to provide understanding into the economies of each area

Connecting Cleveland: Economic Impact of Greater Cleveland Regional Transit Authority

The Center for Economic Development (the Center) produced this economic impact report for the Greater Cleveland Regional Transit Authority (GCRTA) to illustrate how their operations, infrastructure, and services contribute to Cuyahoga County’s economy. Cleveland is fortunate among the Midwestern metropolitan areas to have a rich transit history and infrastructure which is actively updated and shapes regional life. Among similar metro transit authorities in the region (Detroit, Cincinnati, and others), GCRTA was second only to Pittsburgh’s Port Authority of Allegheny County in terms of ridership and vehicle-revenue miles in 2017. With 2,300 full-time employees in 2017, GCRTA is the 13th largest Northeast Ohio employer based in Cleveland and the 38th largest in the region. GCRTA’s service area is Cuyahoga County; its 2017 operating budget totaled $247 million, and its capital budget varied from$60 million to $87 million over the last five years. The scale of GCRTA operations creates an economic impact on the regional economy and affects the lives of those who rely on its services to get to work, school, and local amenities. While its employees reside across Greater Cleveland, the lion\u27s share live in Cuyahoga County (82%). GCRTA spends roughly 24% of its operating budget and 30% of its capital expenditures within Cuyahoga County by purchasing from local suppliers. The direct employment and operations of GCRTA, their purchases from suppliers within Cuyahoga County, and local spending of GCRTA employees’ salaries and salaries of employees of local suppliers give a boost to the regional economy

Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex.

Recent translational work has shown that fibromyalgia might be an autoimmune condition with pathogenic mechanisms mediated by a peripheral, pain-inducing action of immunoglobulin G (IgG) antibodies binding to satellite glia cells (SGC) in the dorsal root ganglia. A first clinical assessment of the postulated autoimmunity showed that fibromyalgia subjects (FMS) had elevated levels of antibodies against SGC (termed anti-SGC IgG) compared to healthy controls and that anti-SGC IgG were associated with a more severe disease status. The overarching aim of the current study was to determine whether the role of anti-SGC IgG in driving pain is exclusively through peripheral mechanisms, as indirectly shown so far, or could be attributed also to central mechanisms. To this end, we wanted to first confirm, in a larger cohort of FMS, the relation between anti-SGC IgG and pain-related clinical measures. Secondly, we explored the associations of these autoantibodies with brain metabolite concentrations (assessed via magnetic resonance spectroscopy, MRS) and pressure-evoked cerebral pain processing (assessed via functional magnetic resonance imaging, fMRI) in FMS. Proton MRS was performed in the thalamus and rostral anterior cingulate cortex (rACC) of FMS and concentrations of a wide spectrum of metabolites were assessed. During fMRI, FMS received individually calibrated painful pressure stimuli corresponding to low and high pain intensities. Our results confirmed a positive correlation between anti-SGC IgG and clinical measures assessing condition severity. Additionally, FMS with high anti-SGC IgG levels had higher pain intensity and a worse disease status than FMS with low anti-SGC IgG levels. Further, anti-SGC IgG levels negatively correlated with metabolites such as scyllo-inositol in thalamus and rACC as well as with total choline and macromolecule 12 in thalamus, thus linking anti-SGC IgG levels to the concentration of metabolites in the brain of FMS. However, anti-SGC IgG levels in FMS were not associated with the sensitivity to pressure pain or the cerebral processing of evoked pressure pain. Taken together, our results suggest that anti-SGC IgG might be clinically relevant for spontaneous, non-evoked pain. Our current and previous translational and clinical findings could provide a rationale to try new antibody-related treatments in FMS