Bagging Support Vector Machines for Leukemia Classification

Abstract Leukemia is one of the most common cancer type, and its diagnosis and classification is becoming increasingly complex and important. Here, we used a gene expression dataset and adapted bagging support vector machines (bSVM) for leukemia classification. bSVM trains each SVM seperately using bootstrap technique, then aggregates the performances of each SVM by majority voting. bSVM showed accuracy between 87.5% -92.5%, area under ROC curve between 98.0% -99.2%, F-measure between 90.5% -92.7% and outperformed single SVM and other classification methods. We also compared our results with other study results which used the same dataset for leukemia classification. Experimental results revealed that bSVM showed the best performance and can be used as a biomarker for the diagnose of leukemia disease

Changing perceptions of general health in the Kayseri Province, Turkey in 2004 and 2017: A population-based study

AimSelf-rated health (SRH) and health-related quality of life (HRQoL) have closely related outcomes in measuring general health status in community-based studies. The aim of this study is to determine changes in the self-perceived overall health of people and affected factors by comparing the findings of two studies conducted in the same research area.MethodsBoth studies were conducted using the same measurement tools in households determined by random sampling techniques in the same research areas. The first and second studies were conducted with 1,304 and 1,533 people residing in 501 and 801 households in 2004 and 2017, respectively. The demographic data form, the Nottingham Health Profile (NHP), and a single-item SRH questionnaire were used for data collection.ResultsThe rate of good SRH increased from 56% to 70% while the average NHP score decreased from 30.87 to 20.34. The predictors of negative health perceptions were the presence of chronic diseases (OR 3.4–2.7-times higher), being female (OR.1.4–1.5 times higher), and the completion of primary education only (OR. 2.7–2.8 times higher) both 2004 and 2017. Living 500–1,000 m from the nearest healthcare facility was the main protective variable against poor SRH.ConclusionsGood SRH and HRQoL have increased significantly over time. Chronic diseases, education, and gender are the strongest predictors of poor SRH

Normal ağırlıklı ve obez üniversite öğrencilerinde fiziksel aktivite

Objective:  The specific objective of this study was to examine the physical activity paterns among  normal weight and obes university students.Materials And Method: This cross-sectional research study was carried out on the 176 university students. As a data-collecting device, the Physical activity assessment questionnaire (FADA) were used.  An additional questionnaire was administered to obtain Body Mass İndex (BKİ) and demographic data.Results: 8.5% (15) of students were obes (Body Mass Index ? 25).  The mean age, gender, where the student lived , family type, social guarantee and income were not statistically different between subjects who were normal weigth and subjects who were obes (p>0.05). There was  difference between normal weigth and obes groups from the perspective of FADA stair, FADA sport, FADA travel and FADA total variables, in physical activity measurement (p<0.05). When the obes group were catagorized according to their total physical activity score which was obtained from FADA,  83.5 % ( 15) of them found as  sedentary. A negatively significant correlation was found between BKİ and FADA stair, spor, travel, total scores (r= -0.223- 0.285, p<0.05). According to Binary logistic regression analysis, itwas found that the FADA spor and total decreased, as the value of BKİ increased (p<0.02).Conclusions: Proper weigth and higher physical activity levels should be promoted among university students . Additionally, schools should provide opportunities for young people to participate in a wider range of physical activities that address their individual needs while promoting the health benefits of engaging in regular exercise.Amaç: Çalışmanın amacı, normal ağırlıktaki ve obez üniversite öğrencileri arasında, fiziksel aktivite paternlerini araştırmaktır.Gereç ve Yöntem:Kesitsel bu çalışma, 176 üniversite öğrencisini kapsamaktadır. Veri toplama aracı olarak, Fiziksel Aktiviteyi Değerlendirme Anketi (FADA) kullanılmıştır. İlave bir anket, Beden Kitle İndeksi (BKİ) ve demografik verileri toplamak için kullanılmıştır.Bulgular: Öğrencilerin % 8.5 (15)’u obeztir (Beden Kitle İndeksi  ? 25). Yaş, cinsiyet, yaşadığı yer, aile tipi, sosyal güvence ve aylık gelir  açısından, normal ağırlıklı ve obez gruplar arasında istatistiksel fark bulunmamıştır (p>0.05).  Fiziksel aktivite ölçümünün, FADA merdiven, FADA spor, FADA ulaşım ve FADA toplam değişkenleri açısından, normal ağırlıklı ve obez grupları arasında fark vardır (p<0.05). FADA’dan alınan toplam fiziksel aktivite puanına göre, obez grubun 15 (%83.4)’ü  sedenter olarak bulunmuştur. BKİ ile, FADA merdiven, spor, ulaşım ve toplam değerleri arasında negatif bir ilişki bulunmuştur (r= -0.223- 0.285, p<0.05). İkili lojistikağlık regresyon analizine göre, BKİ değeri arttıkça, FADA spor ve toplam değerlerinin azaldığı bulunmuştur (p<0.02).Sonuçlar:Üniversite öğrencileri arasında, uygun ağırlıkta olmak ve yüksek fiziksel aktivite seviyeleri teşvik edilmelidir. Ayrıca okullar, düzenli fiziksel aktivite yapmanın sağlığa faydalarını açıklarken,  bireysel ihtiyaçları için gençlere, fiziksel aktivitelere geniş kapsamlı katılımları için fırsatlar sağlamalıdırlar

Reliability and validity of the Turkish version of king's Parkinson's disease pain scale

Objective: Pain, a nonmotor symptom in Parkinson's disease (PD), affects approximately 40%-85% of patients and adversely affects their daily activities. Therefore, our aim was to establish the validity and reliability of the Turkish version of King's PD Pain Scale (KPDPS) and to make it available for Turkish patients with PD patients. Methods: The first phase of the study involved the translation and adaptation of the KPDPS to Turkish. For the language validity of the scale, a translation back-translation method was applied, and expert's opinion was considered for content validity. In the second stage, the developed Turkish scale was administered to 152 patients with PD. In the study, test-retest was performed in 50 patients for 1 week. Results: The internal consistency value was found as 0.856 in the KPDPS. When the test-retest was performed, the internal consistency value of the scale showed excellent reliability. The test-retest-Cronbach's alpha value for the whole scale was 0.827. According to the data analysis results, it showed that 14 items on the scale were sufficient for the evaluation of pain in patients with PD. Conclusion: The results from this study show that KPDPS items have adequate internal consistency and test-retest reliability. The Turkish KPDPS can be used as a reliable and valid instrument for assessing the pain symptoms common to patients with PD