973 research outputs found
Piloting of a suicide first aid gatekeeper training (online) for children and young people in conflict affected areas in Syria
Suicide among internally displaced people remains an under-researched public health issue especially in conflict affected countries. Given the limited and sometimes inaccessible mental health services, there is a need for scalable evidence-based suicide prevention programmes that could be delivered by trained and supervised non-specialists. The Suicide First Aid Guidelines approach aims to support humanitarian workers who deal directly with children and families with the appropriate knowledge and skills to identify and support those at risk of suicide until they can access further specialized support services or until the crisis passes.
This paper presents the findings of an online pilot training of 56 humanitarian workers from different sectors (e.g. Child Protection, Nutrition and Mental Health and Psychosocial Support) in conflict affected areas in Syria. The quantitative and qualitative evaluations were based on pre- and post-training questionnaires and revision journals completed between training sessions. Suggestions and examples provided in the journals and during the trainings were incorporated into the succeeding trainings. This was to contextualize and modify the gatekeeper training to fit the Syrian context and provide adaptations for future research and suicide prevention guidelines. Overall, the evaluation indicated that the pilot training raised awareness and improved participants’ knowledge on how to assist a suicidal person, including warning signs. It also contributed to a positive change in attitude or beliefs towards suicide. Although the pilot training was considered adequate for the Syrian context some improvements were suggested
Effect of errors, redundancy, and solvent content in the molecular replacement procedure for the structure determination of biological macromolecules.
Differential expression of transcription factor- and further growth-related genes correlates with contrasting cluster architecture inVitis vinifera'Pinot Noir' andVitisspp. genotypes
A unified evaluation of iterative projection algorithms for phase retrieval
Iterative projection algorithms are successfully being used as a substitute
of lenses to recombine, numerically rather than optically, light scattered by
illuminated objects. Images obtained computationally allow aberration-free
diffraction-limited imaging and the possibility of using radiation for which no
lenses exist. The challenge of this imaging technique is transfered from the
lenses to the algorithms. We evaluate these new computational ``instruments''
developed for the phase retrieval problem, and discuss acceleration strategies.Comment: 12 pages, 9 figures, revte
Mutations in the miR396 binding site of the growth-regulating factor gene VvGRF4 modulate inflorescence architecture in grapevine.
A human antibody against Zika virus crosslinks the E protein to prevent infection
The recent Zika virus (ZIKV) epidemic has been linked to unusual and severe clinical manifestations including microcephaly in fetuses of infected pregnant women and Guillian-Barré syndrome in adults. Neutralizing antibodies present a possible therapeutic approach to prevent and control ZIKV infection. Here we present a 6.2 Å resolution three-dimensional cryo-electron microscopy (cryoEM) structure of an infectious ZIKV (strain H/PF/2013, French Polynesia) in complex with the Fab fragment of a highly therapeutic and neutralizing human monoclonal antibody, ZIKV-117. The antibody had been shown to prevent fetal infection and demise in mice. The structure shows that ZIKV-117 Fabs cross-link the monomers within the surface E glycoprotein dimers as well as between neighbouring dimers, thus preventing the reorganization of E protein monomers into fusogenic trimers in the acidic environment of endosomes
Electric sector policy, technological change, and U.S. emissions reductions goals: Results from the EMF 32 model intercomparison project
The Energy Modeling Forum (EMF) 32 study compares a range of coordinated scenarios to explore implications of U.S. climate policy options and technological change on the electric power sector. Harmonized policy scenarios (including mass-based emissions limits and various power-sector-only carbon tax trajectories) across 16 models provide comparative assessments of potential impacts on electric sector investment and generation outcomes, emissions reductions, and economic implications. This paper compares results across these policy alternatives, including a variety of technological and natural gas price assumptions, and summarizes robust findings and areas of disagreement across participating models. Under a wide range of policy, technology, and market assumptions, model results suggest that future coal generation will decline relative to current levels while generation from natural gas, wind, and solar will increase, though the pace and extent of these changes vary by policy scenario, technological assumptions, region, and model. Climate policies can amplify trends already under way and make them less susceptible to future market changes. The model results provide useful insights to a range of stakeholders, but future research focused on intersectoral linkages in emission reductions (e.g., the role of electrification), effects of energy storage, and better coverage of bioenergy with carbon capture and storage (BECCS) can improve insights even further
Electric Sector Policy, Technological Change, and U.S. Emissions Reductions Goals: Results from the EMF 32 Model Intercomparison Project
The Energy Modeling Forum (EMF) 32 study compares a range of coordinated scenarios to explore implications of U.S. climate policy options and technological change on the electric power sector. Harmonized policy scenarios (including mass-based emissions limits and various power-sector-only carbon tax trajectories) across 16 models provide comparative assessments of potential impacts on electric sector investment and generation outcomes, emissions reductions, and economic implications. This paper compares results across these policy alternatives, including a variety of technological and natural gas price assumptions, and summarizes robust findings and areas of disagreement across participating models. Under a wide range of policy, technology, and market assumptions, model results suggest that future coal generation will decline relative to current levels while generation from natural gas, wind, and solar will increase, though the pace and extent of these changes vary by policy scenario, technological assumptions, region, and model. Climate policies can amplify trends already under way and make them less susceptible to future market changes. The model results provide useful insights to a range of stakeholders, but future research focused on intersectoral linkages in emission reductions (e.g., the role of electrification), effects of energy storage, and better coverage of bioenergy with carbon capture and storage (BECCS) can improve insights even further
Virus reactivations and serology patterns following first-line therapy with alemtuzumab or fludarabine-based combination therapy in patients with chronic lymphocytic leukemia
- …