Integrating fish resources to agro-ecosystem analyses

In October 2005, a consortium of partners led by the International Water Management Institute (IWMI) proposed a project aimed at integrating fish resources management in agricultural management in the Tonle Sap area. This 2-years project assistance was accepted for funding by the Challenge Program on Water and Food and started in January 2008. The overall goal of this project is to improve allocation and use of water in combined farming and fishing systems in order to enhance food security of rural communities and water productivity. The general objectives of the Fisheries component are: 1) to contribute to the review of existing fisheries and aquaculture information, assessment and data collection systems and existing databases from a fisheries perspective 2) to determine key questions that could be asked at the commune level that would enable the identification of fisheries issues for different agroecosystem zones. These would include both threats and potential threats to fisheries based on key ecological variables and opportunities that fisheries and aquaculture could represent in local livelihoods.Research, Lake fisheries, Agropisciculture, Ecosystems, Analysis, Cambodia, Tonle Sap L.,

An Activity-Based Nanosensor for Traumatic Brain Injury.

Currently, traumatic brain injury (TBI) is detected by medical imaging; however, medical imaging requires expensive capital equipment, is time- and resource-intensive, and is poor at predicting patient prognosis. To date, direct measurement of elevated protease activity has yet to be utilized to detect TBI. In this work, we engineered an activity-based nanosensor for TBI (TBI-ABN) that responds to increased protease activity initiated after brain injury. We establish that a calcium-sensitive protease, calpain-1, is active in the injured brain hours within injury. We then optimize the molecular weight of a nanoscale polymeric carrier to infiltrate into the injured brain tissue with minimal renal filtration. A calpain-1 substrate that generates a fluorescent signal upon cleavage was attached to this nanoscale polymeric carrier to generate an engineered TBI-ABN. When applied intravenously to a mouse model of TBI, our engineered sensor is observed to locally activate in the injured brain tissue. This TBI-ABN is the first demonstration of a sensor that responds to protease activity to detect TBI

Neuronal activation in the hypothalamus and brainstem during feeding in rats

SummaryWe trained rats to a regime of scheduled feeding, in which food was available for only 2 hr each day. After 10 days, rats were euthanized at defined times relative to food availability, and their brains were analyzed to map Fos expression in neuronal populations to test the hypothesis that some populations are activated by hunger whereas others are activated by satiety signals. Fos expression accompanied feeding in several hypothalamic and brainstem nuclei. Food ingestion was critical for Fos expression in noradrenergic and non-noradrenergic cells in the nucleus tractus solitarii and area postrema and in the supraoptic nucleus, as well as in melanocortin-containing cells of the arcuate nucleus. However, anticipation of food alone activated other neurons in the arcuate nucleus and in the lateral and ventromedial hypothalamus, including orexin neurons. Thus orexigenic populations are strongly and rapidly activated at the onset of food presentation, followed rapidly by activity in anorexigenic populations when food is ingested

Biological reviews of important Cambodian fish species, based on fishbase 2004 volume 2

This document is a review of all the information published worldwide about ten fish species that contribute significantly to Cambodian fishery resources.Freshwater fish, Cambodia, Pangasius larnaudii, Clarias batrachus, Cirrhinus microlepis, Leptobarbus hoevenii, Thynnichthys thynnoides, Trichogaster microlepis, Trichogaster pectoralis, Anabas testudineus, Boesemania microlepis, Oxyeleotris marmorata

Biological reviews of important Cambodian fish species, based on fishbase 2004 Volume 1

This document is a review of all the information published worldwide about ten fish species that contribute significantly to Cambodian fishery resources.Freshwater fish, Cambodia, Channa striata, Channa micropeltes, Barbonymus altus, Barbonymus gonionotus, Cyclocheilichthys apogon, Cyclocheilichthys enoplos, Henicorhynchus lineatus, Henicorhynchus siamensis, Pangasius hypophthalmus, Pangasius djambal

Equilibrium onions?

We demonstrate the possibility of a stable equilibrium multi-lamellar ("onion") phase in pure lamellar systems (no excess solvent) due to a sufficiently negative Gaussian curvature modulus. The onion phase is stabilized by non-linear elastic moduli coupled to a polydisperse size distribution (Apollonian packing) to allow space-filling without appreciable elastic distortion. This model is compared to experiments on copolymer-decorated lamellar surfactant systems, with reasonable qualitative agreement

NOACs added to WHO’s essential medicines list: recommendations for future policy actions

The introduction of non-vitamin K antagonists oral anticoagulants, a class of medicines which includes dabigatran, apixaban, edoxaban and rivaroxaban, has resulted in improvements in the safety and efficacy of non valvular atrial fibrillation treatment for stroke prevention, with significant reductions in stroke, intracranial haemorrhage, and mortality. For these reasons, a team of World Heart Federation Emerging Leaders led efforts to add non-vitamin K antagonists oral anticoagulants to the World Health Organization’s Model List of Essential Medicines in 2019. Following the inclusion of this class of medicines in the Essential Medicines List, this editorial proposes several recommendations to improve the accessibility, affordability and acceptability of non-vitamin K oral anticoagulants, especially in low- and middle-income settings, in order to successfully manage non-valvular atrial fibrillation and to lower the risk of stroke