Spreadsheet modeling for research and teaching: Programming without programming

Spreadsheets can be used to focus academic research and teaching on theoretical models. Examples of models from learning, social psychology, and perception are presented to illustrate how spreadsheet techniques work. Two strengths of this approach are emphasized: (1) Spreadsheets provide a relatively user-friendly alternative to some kinds of instructional and research programming; and (2) the linked tables and graphs of modern spreadsheets provide a powerful display medium and a fast way to examine the behavior of models as parameters change. I suggest some models for which spreadsheets may be appropriate

Goodness-of-fit patterns in a computer cross-validation procedure comparing a linear and a threshold model

Cross-validation is the process of comparing a model’s predictions to data that were not used in the estimation of model parameters. Cross-validation may have some value in identifying source models, especially in cases where the corresponding fitted models require the estimation of different numbers of parameters. Some of the information available from cross-validation is illustrated using a linear and a threshold model, and goodness-of-fit patterns are contrasted with those of conventional model-fitting

Taking time to appreciate the scenery: an exploration of PhD supervision as pedagogy

A PhD generates new knowledge and builds new links with existing research literature – by definition a ‘mind-bending’ exercise, even without the additional challenges brought on by Covid-19 restrictions. As an undertaking, it is both self-directed and requiring of sustained independence (a part-time PhD may require sustained investment for up to eight years) and demanding of trust and effective communication between candidate and supervisor. This project used visual and creative methodologies to explore an emerging PhD supervisory relationship as it developed during the lockdown restraints of the pandemic. It sought to understand this relationship through the development of a visual and creative methodology designed to help both parties understand the ontological and epistemological assumptions underpinning the research project. Visual artefacts and literary extracts were discussed as metaphors for the supervisor/supervisee relationship and the PhD ‘journey’, providing an exploration that proved valid and valuable to both supervisor and candidate

Activation of the Unfolded Protein Response Enhances Motor Recovery after Spinal Cord Injury

Spinal cord injury (SCI) is a major cause of paralysis, and involves multiple cellular and tissular responses including demyelination, inflammation, cell death and axonal degeneration. Recent evidence suggests that perturbation on the homeostasis of the endoplasmic reticulum (ER) is observed in different SCI models; however, the functional contribution of this pathway to this pathology is not known. Here we demonstrate that SCI triggers a fast ER stress reaction (1–3 h) involving the upregulation of key components of the unfolded protein response (UPR), a process that propagates through the spinal cord. Ablation of X-box-binding protein 1 (XBP1) or activating transcription factor 4 (ATF4) expression, two major UPR transcription factors, leads to a reduced locomotor recovery after experimental SCI. The effects of UPR inactivation were associated with a significant increase in the number of damaged axons and reduced amount of oligodendrocytes surrounding the injury zone. In addition, altered microglial activation and pro-inflammatory cytokine expression were observed in ATF4 deficient mice after SCI. Local expression of active XBP1 into the spinal cord using adeno-associated viruses enhanced locomotor recovery after SCI, and was associated with an increased number of oligodendrocytes. Altogether, our results demonstrate a functional role of the UPR in SCI, offering novel therapeutic targets to treat this invalidating condition

Enhancing the Messages Displayed on Dynamic Message Signs

A human factors study was carried out to help enhance ways tocommunicate with highway motorists through dynamic message signs (DMS).Overhead mounted DMSs have been increasingly used by highway authorities inthe United States to present real-time traffic information and travel advice tomotorists. It is critical to post sign messages that can be quickly and clearlyunderstood by motorists, especially in high-volume traffic and construction/repairzones. Properly worded and formatted sign messages could spell the differencebetween comprehension and confusion. Message display factors investigated inthe study include display effects, color schemes, wording, and formats. Twoapproaches were employed in this study. First, a questionnaire survey wasdeveloped to collect motorists’ preferences regarding various message displayfactors. Second, a series of lab driving simulation experiments were set up toassess the effects of these factors and their interactions on motorists’comprehension of DMS messages. Study results suggested that static, one-framedmessages with more specific wording and no abbreviations were preferred.Amber or green or a green-amber combination were the most favored colors.Younger subjects took less response time to the DMS stimuli with higheraccuracy than older subjects. There were no significant gender differences

‘Howling at the scrabble-board’: Exploring classroom literature from an autistic viewpoint

There has, to date, been little discussion of how autism may affect the experience of the reading of fiction for pupils in the classroom, other than through a deficit model. One of the researchers in this study (‘Celia’) is training to be a secondary school English teacher and identifies as autistic. Her experience provides an enriched understanding of the subject and enables the study to be undertaken in line with best practice for autism research. Her experiences are explored within the concepts of Theory of Mind, empathic regulation, language awareness and local rather than global processing bias. Impact on managing authentic engagement with texts for all pupils is discussed, together with specific questions for teachers regarding appropriate support for – and celebration of – autistic pupils’ reactions to fiction

Tin-containing zeolites are highly active catalysts for the isomerization of glucose in water

The isomerization of glucose into fructose is a large-scale reaction for the production of high-fructose corn syrup (HFCS; reaction performed by enzyme catalysts) and recently is being considered as an intermediate step in the possible route of biomass to fuels and chemicals. Here, it is shown that a large-pore zeolite that contains tin (Sn-Beta) is able to isomerize glucose to fructose in aqueous media with high activity and selectivity. Specifically, a 10% (wt/wt) glucose solution containing a catalytic amount of Sn-Beta (1∶50 Sn:glucose molar ratio) gives product yields of approximately 46% (wt/wt) glucose, 31% (wt/wt) fructose, and 9% (wt/wt) mannose after 30 min and 12 min of reaction at 383 K and 413 K, respectively. This reactivity is achieved also when a 45 wt% glucose solution is used. The properties of the large-pore zeolite greatly influence the reaction behavior because the reaction does not proceed with a medium-pore zeolite, and the isomerization activity is considerably lower when the metal centers are incorporated in ordered mesoporous silica (MCM-41). The Sn-Beta catalyst can be used for multiple cycles, and the reaction stops when the solid is removed, clearly indicating that the catalysis is occurring heterogeneously. Most importantly, the Sn-Beta catalyst is able to perform the isomerization reaction in highly acidic, aqueous environments with equivalent activity and product distribution as in media without added acid. This enables Sn-Beta to couple isomerizations with other acid-catalyzed reactions, including hydrolysis/isomerization or isomerization/dehydration reaction sequences [starch to fructose and glucose to 5-hydroxymethylfurfural (HMF) demonstrated here]

Creativity, artificial intelligence, and the requirement of human authors and inventors in copyright and patent law

Copyright and patent law require the identification of an author or inventor, and further require the author or inventor to be human. We explore this requirement primarily with reference to U.S. law and provide additional illustrations from U.K. and E.U. law. A key rationale underlying the requirement of a human author or inventor is that there is something special and important about human creativity. As AI, particularly generative AI, becomes more capable of producing outputs that look like they could have been human-created, arguments have increasingly been raised that the AI-generated outputs should be afforded copyright and patent protection, on the same basis as those made by human authors and inventors. And there have been arguments that these AI-generated outputs exhibit sufficient creativity, novelty, or innovativeness, to satisfy the laws’ underlying creativity rationale. We examine the concept of creativity from a multidisciplinary perspective, and identify three conceptually distinct components, all of which are necessary for a complete account of creativity. The external component refers to whether an artifact (or idea, or other thing) exhibits the qualities of being novel, valuable, and (on some accounts) surprising. The subjective component focuses on the psychological process of a creative act, which appears to involve a dance between task-focused and mental-wandering states, mediated by a salience functionality, where the person recognizes and selects novel, appropriate ideas. Third, embedded in the analysis of both the external and subjective components is a (largely-implicit) recognition that the social context is integral to creativity; it plays a role in determining whether an artifact has value (or is “appropriate”), and influences the subjective psychological process of plucking certain ideas or conceptions out of the flow of mental activity. With this enriched account of creativity, we examine how copyright and patent law value not only the creativity of the artifact, but also (to varying extents) the subjective role and social context as part of creativity. We then consider some ways in which arguments that AI generated artifacts should be eligible for IP protection (e.g., because they are “just as good as” at least some human-generated and IP-eligible artifacts) are insufficient to satisfy the enriched understanding of the creativity requirement underlying the IP laws

How Does Treatment Coverage and Proportion Never Treated Influence the Success of Schistosoma mansoni Elimination as a Public Health Problem by 2030?

Background: The 2030 target for schistosomiasis is elimination as a public health problem (EPHP), achieved when the prevalence of heavy-intensity infection among school-Aged children (SAC) reduces to &lt;1%. To achieve this, the new World Health Organization guidelines recommend a broader target of population to include pre-SAC and adults. However, the probability of achieving EPHP should be expected to depend on patterns in repeated uptake of mass drug administration by individuals. Methods: We employed 2 individual-based stochastic models to evaluate the impact of school-based and community-wide treatment and calculated the number of rounds required to achieve EPHP for Schistosoma mansoni by considering various levels of the population never treated (NT). We also considered 2 age-intensity profiles, corresponding to a low and high burden of infection in adults. Results: The number of rounds needed to achieve this target depends on the baseline prevalence and the coverage used. For low-and moderate-Transmission areas, EPHP can be achieved within 7 years if NT ≤10% and NT &lt;5%, respectively. In high-Transmission areas, community-wide treatment with NT &lt;1% is required to achieve EPHP. Conclusions: The higher the intensity of transmission, and the lower the treatment coverage, the lower the acceptable value of NT becomes. Using more efficacious treatment regimens would permit NT values to be marginally higher. A balance between target treatment coverage and NT values may be an adequate treatment strategy depending on the epidemiological setting, but striving to increase coverage and/or minimize NT can shorten program duration.</p