A COMPARISON OF INTRAVENOUS ONDANSETRON AND PALONOSETRON IN PREVENTING POST-OPERATIVE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY - A RANDOMIZED DOUBLE-BLIND STUDY

Objectives: Post-operative nausea and vomiting (PONV) is a frequently experienced complication following laparoscopic cholecystectomy. This study was planned to compare the antiemetic efficacy of palonosetron with ondansetron in patients undergoing laparoscopic cholecystectomy.Methods: A total of 100 patients undergoing laparoscopic cholecystectomy were randomized into two groups. Group O (n=50) received ondansetron (8 mg) and Group P (n=50) received palonosetron (0.075 mg) 3 min before induction of anesthesia. Post-operatively, patients were assessed for the occurrence of nausea, retching, or vomiting at 0–2, 2–6, 6–24, 0–24, and 24–48 h time intervals. The overall incidence of PONV in time frame (0–48 h) was determined. The need of rescue antiemetic, side effect profile, and patient satisfaction scores were also assessed.Results: The incidence and severity of nausea at all the time intervals were comparable in the two groups. The incidence of vomiting was significantly less in Group P as compared to Group O in 0–2 h (2% vs. 14%, p=0.027) and 0–24 h time intervals (10% vs. 30%, p=0.012). The overall incidence of PONV in 0–48h was lesser in Group P as compared to Group O (28% vs. 50%, p=0.024). Rescue antiemetic was required in greater number of patients in Group O as compared to Group P (p=0.038). Side effect profile and patient satisfaction scores were comparable in the two groups.Conclusion: Palonosetron is better than ondansetron in lowering the overall incidence of PONV in 0–48 h time interval, in patients undergoing laparoscopic cholecystectomy

Effect of Admixture on the Compressive Strength of Composite Cement Mortar

The effect of superplasticizer on the development of composite cement based on flyash/limestone powder as per EN-197-2000 has been studied. Various mixes of fly ash and limestone up to 40% has been blended. The results have been compared with clinker of 43 grade ordinary portland cement used in the present study. 1 day strength of mixes with 5% and 10% limestone powder has been found to be is comparable to control. Further, it has been found that 28 days strength of mix with 15% lime stone powder and 25% fly ash gives more than 32.5 R required for composite cement. With the use of superplasticizer, strength has been found comparable or more in all the mixes at 1day to 43 grade OPC. X-ray diffraction (XRD) analysis of various mixes at different hydration times has also been evaluated.

Exploring Factors Influencing Job Satisfaction and Its Bearing on Performance among Dentists in Central India

Purpose: Presence of motivating factors facilitates higher job performance, whereas their absence leads to job dissatisfaction. The study was conducted with the objective of assessing the level of job satisfaction and the associated factors among dentists in Central India. Methods: Data was collected from 155 graduate and postgraduate faculties from the six dental schools of Bhopal city, Central India. Demographic and professional information was collected along with 10 point ‘Warr-Cook-Wall’ (WCW) job satisfaction scale. Chi Square test was used to compare between categorical variables. Logistic and linear regression analysis was performed to determine the factors associated with job satisfaction. Results: Seventy four male (47.7%) and eighty one female (52.3%) dentists participated in the study, with mean age of the study sample being 33.20 ± 6.7 years. Dentists were highly satisfied with colleagues and fellow workers and dissatisfied with income. Dentists with longer academic experience were more satisfied with income than younger dentists with less experience (p < 0.05).  Female dentists were more dissatisfied than male counterparts (p < 0.05). Age, gender and qualification together explained for 49% variance associated with job satisfaction. Postgraduate faculty were 3.55 times more satisfied with income than graduate faculty (p < 0.05). Conclusions: Study confirms higher qualification and presence of motivating factors mainly good income and cordial relations with colleagues and fellow workers have greatest impact on overall job satisfaction. It highlights the issues in the dental profession needing attention and would be helpful for further improvement of the working conditions for dentists. Keywords: Dentists, Income, Job satisfaction, Motivation, Workplac

Effect of Twin Vertical Stabilizers on Lateral Directional Static Stability of an Aircraft – A Computational Study

The advantages of twin vertical Stabilizers over a single vertical Stabilizer of an aero plane are the rationale for this study. For conventional aero planes, the use of double vertical Stabilizers is being considered. The contribution to lateral stability has been examined for this application. XFLR5 software was used to conduct the overall analysis. The analysis was conducted for a single vertical Stabilizer as well as twin vertical Stabilizers, and the findings were compiled and correlated. It is critical to be able to fully explain and evaluate the stability and control parameters. It is crucial to understand the relationship between the aerodynamics of the airframe and its stability characteristics in order to increase flight endurance and deployment effectiveness. The stability analysis based on the dynamic model of the twin boom vertical Stabilizer is presented in this paper. The lateral-directional stability of an aero plane with a single vertical tail is determined to be 20% more efficient than that with twin boom vertical Stabilizers. The trim condition is moderately satisfied by an aircraft with twin vertical Stabilizers

A Study of Prescribing Habits of Low Molecular Weight Heparin in Cardiovascular Disease in Tertiary Care Hospital

Background and Objective: Cardiovascular Diseases (CVDs) are the leading non-communicable diseases and also leading cause of morbidity and mortality worldwide. Low Molecular Weight Heparin (LMWHs) is frequently prescribed medication in CVDs. Prescribing pattern of LMWHs in CVDs is necessary to recommends modifications to achieve rational and cost-effective medical care. Methodology: An inpatients hospital based observational prospective study for a period of six months was carried out. Data was collected from patient medication sheet and analyzed by suitable methods and standard references. Results and Discussion: In our study, a total of 120 patients were enrolled out of 120 patients 84 were male and 36 were female. Antiplatelet drug is maximum prescribing drug in 98 (81.34%) patients out of 120, then after hypolipidaemic drugs in 94 (78.02%), Anticoagulant in 92 (76.36%), Antibiotics in 90 (74.70%), Antianginal in 69 (57.27), Antihypertensive in 64 (53.12%), Diuretics in 59 (48.97%). LMWHs are prescribed in 78 (65%) in which Enoxaparin is prescribed in 67(55%) and Dalteparin in 11(10%) patients out of 120 patients. Total 259 Drug-Drug Interactions (DDI) were found in which 67 were Major, 140 were Moderate, and 52 were Minor. Conclusion: The study show LMWHs are highly prescribed category of anticoagulant. Enoxaparin is prescribed morethan Dalteparin. Antiplatelet drugs are prescribed to every patient who is prescribed with LMWHs to prevent embolic event. Chance of DDI is increases with these combinations. LMWHs and Fibrinolytic drugs are very costly and impart maximum economic burden to middle class family

Brassica-Aphid Interaction: Modulated Challenges and Sustainable Approach for Management

Insect pests act as main barrier in enhancing yield potential of Brassica crops. Lipaphis erysimi is considered as one of the most destructive insect species in mustard production due to its voracious type feeding and multiplication. Therefore application of insecticide is inevitable for cultivation of cruciferous crops, although systemic insecticides has been found to be suitable for management of aphid, despite of high cost, residual effect and ecological ramification have necessitated the application of bio and botanical insecticides as novel approach and are recorded significant in research. Aphids having exclusively viviparous parthenogenesis type reproduction from January to March month with the completion of eight generations are helpful in quick mass multiplication. Natural enemies Coccinella spp., Syrphid larvae and bio-pesticide found effective in suppress aphid numbers. Manipulation in sowing dates of mustard crop provides good yield and less incidence of aphid which is proved through research. Lack of environmental resistant varieties has dispensed toward non feasibility of conventional breeding approaches for developing aphid-resistant Brassica. Although application of genetic engineering plan has resulted in moderate success in development of aphid resistance, so far commercialization of such genetically modified crops has not conceivable, intimate the necessity of further insights in to host plant and aphid communication to form effective approach against aphid resistance. Therefore in this chapter the components involved in Brassica aphid communication are highlighted and present statuses and problem in aphid management are discussed

Effect of Differences in Month and Location of Measurement in Estimating Prevalence and Trend of Wasting and Stunting in India in 2005-2006 and 2015-2016

Background: Child undernutrition in India remains widespread. Data from the National Family Health Survey 3 and 4 (NFHS-3 and NFHS-4) suggest that wasting prevalence has increased while stunting prevalence has declined. Objective: The objectives of this study were to do the following: ) describe wasting and stunting by month of measurement in India in children surveys, and ) test whether differences in the timing of anthropometric data collection and in states between survey years introduced bias in the comparison of estimates of wasting and stunting between NFHS-3 and NFHS-4. Methods: Data on wasting and stunting for 42,608 and 232,744 children aged \u3e5 y in the NFHS-3 and NFHS-4 survey rounds were analyzed. Differences in the prevalence of wasting and stunting by month of year and by state of residence were examined descriptively. Regression analyses were conducted to test the sensitivity of the estimate of differences in wasting and stunting prevalence across survey years to both state differences and seasonality. Results: Examination of the patterns of wasting and stunting by month of measurement and by state across survey years reveal marked variability. When both state and month were adjusted, regardless of the method used to account for sample size, there was a small negative difference from 2005-2006 to 2015-2016 in the prevalence of wasting (-0.8 ± 0.6 percentage points; = 0.2) and a negative difference in stunting prevalence (-8.3 ± 0.7 percentage points; \u3c 0.001), indicating a small bias for wasting but not for stunting in unadjusted analyses. Conclusions: State and seasonal differences may have introduced bias to the estimated difference in prevalence of wasting between the survey years but did not do so for stunting. Future data collection should be designed to maximize consistency in coverage of both time and place

Mapping of variations in child stunting, wasting and underweight within the states of India: the Global Burden of Disease Study 2000–2017

Background To inform actions at the district level under the National Nutrition Mission (NNM), we assessed the prevalence trends of child growth failure (CGF) indicators for all districts in India and inequality between districts within the states. Methods We assessed the trends of CGF indicators (stunting, wasting and underweight) from 2000 to 2017 across the districts of India, aggregated from 5 × 5 km grid estimates, using all accessible data from various surveys with subnational geographical information. The states were categorised into three groups using their Socio-demographic Index (SDI) levels calculated as part of the Global Burden of Disease Study based on per capita income, mean education and fertility rate in women younger than 25 years. Inequality between districts within the states was assessed using coefficient of variation (CV). We projected the prevalence of CGF indicators for the districts up to 2030 based on the trends from 2000 to 2017 to compare with the NNM 2022 targets for stunting and underweight, and the WHO/UNICEF 2030 targets for stunting and wasting. We assessed Pearson correlation coefficient between two major national surveys for district-level estimates of CGF indicators in the states. Findings The prevalence of stunting ranged 3.8-fold from 16.4% (95% UI 15.2–17.8) to 62.8% (95% UI 61.5–64.0) among the 723 districts of India in 2017, wasting ranged 5.4-fold from 5.5% (95% UI 5.1–6.1) to 30.0% (95% UI 28.2–31.8), and underweight ranged 4.6-fold from 11.0% (95% UI 10.5–11.9) to 51.0% (95% UI 49.9–52.1). 36.1% of the districts in India had stunting prevalence 40% or more, with 67.0% districts in the low SDI states group and only 1.1% districts in the high SDI states with this level of stunting. The prevalence of stunting declined significantly from 2010 to 2017 in 98.5% of the districts with a maximum decline of 41.2% (95% UI 40.3–42.5), wasting in 61.3% with a maximum decline of 44.0% (95% UI 42.3–46.7), and underweight in 95.0% with a maximum decline of 53.9% (95% UI 52.8–55.4). The CV varied 7.4-fold for stunting, 12.2-fold for wasting, and 8.6-fold for underweight between the states in 2017; the CV increased for stunting in 28 out of 31 states, for wasting in 16 states, and for underweight in 20 states from 2000 to 2017. In order to reach the NNM 2022 targets for stunting and underweight individually, 82.6% and 98.5% of the districts in India would need a rate of improvement higher than they had up to 2017, respectively. To achieve the WHO/UNICEF 2030 target for wasting, all districts in India would need a rate of improvement higher than they had up to 2017. The correlation between the two national surveys for district-level estimates was poor, with Pearson correlation coefficient of 0.7 only in Odisha and four small north-eastern states out of the 27 states covered by these surveys. Interpretation CGF indicators have improved in India, but there are substantial variations between the districts in their magnitude and rate of decline, and the inequality between districts has increased in a large proportion of the states. The poor correlation between the national surveys for CGF estimates highlights the need to standardise collection of anthropometric data in India. The district-level trends in this report provide a useful reference for targeting the efforts under NNM to reduce CGF across India and meet the Indian and global targets. Keywords Child growth failureDistrict-levelGeospatial mappingInequalityNational Nutrition MissionPrevalenceStuntingTime trendsUnder-fiveUndernutritionUnderweightWastingWHO/UNICEF target