Sporadic appearance of paralytic spongiform neurodegeneration in a colony of inbred mice is associated with CNS retrovirus expression

Abstract Exogenous and endogenous retroviruses (RV) have been known to induce vacuolar central nervous system neuropathology. Two mice which were juvenile inbred Rocky Mountain White (IRW), showed signs of spontaneous degenerate motor neuron disease. Signs included wasting, unkempt fur, adduction reflex upon tail elevation, kyphosis, and stilted gait by postnatal day 18 (P18). Brains and spinal cords were examined with H&E staining and stained with a broadly reactive retrovirus antibody. When compared to brains of mice with normal vacuolar pathology as well as mice infected with prototypic non-neurovirulent RV, Fr57E and prototypic neurovirulent RV FrCasE, the subject showed less severity but were clearly distinguishable from the non-virulent RV. Spongiosis was seen in the motor areas in both mice. Immunohistochemical staining showed reactive retroviral antibodies, which is evidence of viral protein expression in glia and endothelia. The type of RV present will take further investigation. The ability for spontaneous appearance of competent RV replication arising from endogenous RV in mice that also can induce neurological disease are highlighted. Similar spontaneous retroviral gene expression in humans have been attributed to diseases such as multiple sclerosis and amyotrophic lateral sclerosis. Understanding the viral re-emergence will shed light on the cause of human and animal retroviral disease

Synthetic Mudscapes: Human Interventions in Deltaic Land Building

In order to defend infrastructure, economy, and settlement in Southeast Louisiana, we must construct new land to mitigate increasing risk. Links between urban environments and economic drivers have constrained the dynamic delta landscape for generations, now threatening to undermine the ecological fitness of the entire region. Static methods of measuring, controlling, and valuing land fail in an environment that is constantly in flux; change and indeterminacy are denied by traditional inhabitation. Multiple land building practices reintroduce deltaic fluctuation and strategic deposition of fertile material to form the foundations of a multi-layered defence strategy. Manufactured marshlands reduce exposure to storm surge further inland. Virtual monitoring and communication networks inform design decisions and land use becomes determined by its ecological health. Mudscapes at the threshold of land and water place new value on former wastelands. The social, economic, and ecological evolution of the region are defended by an expanded web of growing land

A deep survey of short GRB host galaxies over z∼0−2z\sim0-2: implications for offsets, redshifts, and environments

A significant fraction ($\sim$30\%) of well-localized short gamma-ray bursts (sGRBs) lack a coincident host galaxy. This leads to two main scenarios: \textit{i}) that the progenitor system merged outside of the visible light of its host, or \textit{ii}) that the sGRB resided within a faint and distant galaxy that was not detected by follow-up observations. Discriminating between these scenarios has important implications for constraining the formation channels of neutron star mergers, the rate and environments of gravitational wave sources, and the production of heavy elements in the Universe. In this work, we present the results of our observing campaign targeted at 31 sGRBs that lack a putative host galaxy. Our study effectively doubles the sample of well-studied sGRB host galaxies, now totaling 72 events of which $28\%$ lack a coincident host galaxy to deep limits ($r$\,$\gtrsim$\,$26$ or $F110W$\,$\gtrsim$\,$27$ AB mag), and represents the largest homogeneously selected catalog of sGRB offsets to date. We find that 70\% of sub-arcsecond localized sGRBs occur within 10 kpc of their host's nucleus, with a median projected physical offset of $5.6$ kpc. Using this larger population, we discover a redshift evolution in the locations of sGRBs: bursts at low-$z$ occur at $2\times$ larger offsets compared to those at $z$\,$>$\,$0.5$. Furthermore, we find evidence for a sample of hostless sGRBs at $z$\,$\gtrsim$\,$1$ that are indicative of a larger high-$z$ population, further constraining the sGRB redshift distribution and disfavoring log-normal delay time models.Comment: Submitted to MNRAS. 39 pages, 18 Figures, 4 Table

The CGM-GRB Study. II. Outflow-Galaxy Connection at z similar to 2-6

We use a sample of 27 gamma-ray bursts (GRBs) at redshift z = 2-6 to probe the outflows in their respective host galaxies (log(M ∗/M ⊙) ∼9-11) and search for possible relations between the outflow properties and those of the host galaxies, such as M ∗, the star formation rate (SFR), and the specific SFR (sSFR). First, we consider three outflow properties: outflow column density (N out), maximum outflow velocity (V max), and normalized maximum velocity (V norm = V max/V circ,halo, where V circ,halo is the halo circular velocity). We observe clear trends of N out and V max with increasing SFR in high-ion-traced outflows, with a stronger (>3σ) V max-SFR correlation. We find that the estimated mass outflow rate and momentum flux of the high-ion outflows scale with SFR and can be supported by the momentum imparted by star formation (supernovae and stellar winds). The kinematic correlations of high-ion-traced outflows with SFR are similar to those observed for star-forming galaxies at low redshifts. The correlations with SFR are weaker in low-ion outflows. This, along with the lower detection fraction in low-ion outflows, indicates that the outflow is primarily high-ion dominated. We also observe a strong (>3σ) trend of normalized velocity (V norm) decreasing with halo mass and increasing with sSFR, suggesting that outflows from low-mass halos and high-sSFR galaxies are most likely to escape and enrich the outer circumgalactic medium (CGM) and intergalactic medium with metals. By comparing the CGM-GRB stacks with those of starbursts at z ∼2 and z ∼0.1, we find that over a broad redshift range, the outflow strength strongly depends on the main-sequence offset at the respective redshifts, rather than simply the SFR

A Sensitive Search for Supernova Emission Associated with the Extremely Energetic and Nearby GRB 221009A

We report observations of the optical counterpart of the long gamma-ray burst (LGRB) GRB 221009A. Due to the extreme rarity of being both nearby ($z = 0.151$) and highly energetic ($E_{\gamma,\mathrm{iso}} \geq 10^{54}$ erg), GRB 221009A offers a unique opportunity to probe the connection between massive star core collapse and relativistic jet formation across a very broad range of $\gamma$-ray properties. Adopting a phenomenological power-law model for the afterglow and host galaxy estimates from high-resolution Hubble Space Telescope imaging, we use Bayesian model comparison techniques to determine the likelihood of an associated SN contributing excess flux to the optical light curve. Though not conclusive, we find moderate evidence ($K_{\rm{Bayes}}=10^{1.2}$) for the presence of an additional component arising from an associated supernova, SN 2022xiw, and find that it must be substantially fainter ($<$ 67% as bright at the 99% confidence interval) than SN 1998bw. Given the large and uncertain line-of-sight extinction, we attempt to constrain the supernova parameters ($M_{\mathrm{Ni}}$, $M_{\mathrm{ej}}$, and $E_{\mathrm{KE}}$) under several different assumptions with respect to the host galaxy's extinction. We find properties that are broadly consistent with previous GRB-associated SNe: $M_{\rm{Ni}}=0.05$ - $0.25 \, \rm{M_\odot}$, $M_{\rm{ej}}=3.5$ - $11.1 \, \rm{M_\odot}$, and $E_{\rm{KE}} = (1.6$ - $5.2) \times 10^{52} \, \rm{erg}$. We note that these properties are weakly constrained due to the faintness of the supernova with respect to the afterglow and host emission, but we do find a robust upper limit on the $M_{\rm{Ni}}$ of $M_{\rm{Ni}}<0.36\, \rm{M_\odot}$. Given the tremendous range in isotropic gamma-ray energy release exhibited by GRBs (7 orders of magnitude), the SN emission appears to be decoupled from the central engine in these systems.Comment: 18 pages, accepted to ApJL, 4 tables, 5 figures. Updated abstract in Previe

A lanthanide-rich kilonova in the aftermath of a long gamma-ray burst

Kilonovae are a rare class of astrophysical transients powered by the radioactive decay of nuclei heavier than iron, synthesized in the merger of two compact objects. Over the first few days, the kilonova evolution is dominated by a large number of radioactive isotopes contributing to the heating rate. On timescales of weeks to months, its behavior is predicted to differ depending on the ejecta composition and merger remnant. However, late-time observations of known kilonovae are either missing or limited. Here we report observations of a luminous red transient with a quasi-thermal spectrum, following an unusual gamma-ray burst of long duration. We classify this thermal emission as a kilonova and track its evolution up to two months after the burst. At these late times, the recession of the photospheric radius and the rapidly-decaying bolometric luminosity ($L_{\rm bol}\propto t^{-2.7\pm 0.4}$) support the recombination of lanthanide-rich ejecta as they cool.Comment: 47 pages, 14 figures, 9 tables; submitted; a minor typo fixe

A structured jet explains the extreme GRB 221009A

Long duration gamma-ray bursts (GRBs) are powerful cosmic explosions, signaling the death of massive stars. Among them, GRB 221009A is by far the brightest burst ever observed. Due to its enormous energy ($E_\textrm{iso}\!\approx$10$^{55}$ erg) and proximity ($z\!\approx$0.15), GRB 221009A is an exceptionally rare event that pushes the limits of our theories. We present multi-wavelength observations covering the first three months of its afterglow evolution. The X-ray brightness decays as a power-law with slope $\approx\!t^{-1.66}$, which is not consistent with standard predictions for jetted emission. We attribute this behavior to a shallow energy profile of the relativistic jet. A similar trend is observed in other energetic GRBs, suggesting that the most extreme explosions may be powered by structured jets launched by a common central engine.Comment: Submitted version. 53 pages, 9 figures, 6 table

A search for optical and near-infrared counterparts of the compact binary merger GW190814

We report on our observing campaign of the compact binary merger GW190814, detected by the Advanced LIGO and Advanced Virgo detectors on August 14th, 2019. This signal has the best localisation of any observed gravitational wave (GW) source, with a 90% probability area of 18.5 deg$^2$, and an estimated distance of ~ 240 Mpc. We obtained wide-field observations with the Deca-Degree Optical Transient Imager (DDOTI) covering 88% of the probability area down to a limiting magnitude of $w$ = 19.9 AB. Nearby galaxies within the high probability region were targeted with the Lowell Discovery Telescope (LDT), whereas promising candidate counterparts were characterized through multi-colour photometry with the Reionization and Transients InfraRed (RATIR) and spectroscopy with the Gran Telescopio de Canarias (GTC). We use our optical and near-infrared limits in conjunction with the upper limits obtained by the community to constrain the possible electromagnetic counterparts associated with the merger. A gamma-ray burst seen along its jet's axis is disfavoured by the multi-wavelength dataset, whereas the presence of a burst seen at larger viewing angles is not well constrained. Although our observations are not sensitive to a kilonova similar to AT2017gfo, we can rule out high-mass (> 0.1 M$_{\odot}$) fast-moving (mean velocity >= 0.3c) wind ejecta for a possible kilonova associated with this merger.Comment: 17 pages, 11 figures, 5 tables; updated acknowledgement section. Accepted for publication in MNRAS (10 September 2020